PMID- 34960064
OWN - NLM
STAT- MEDLINE
DCOM- 20220114
LR  - 20220114
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 12
DP  - 2021 Dec 17
TI  - Bacillus toyonensis SAU-19 Ameliorates Hepatic Insulin Resistance in High-Fat 
      Diet/Streptozocin-Induced Diabetic Mice.
LID - 10.3390/nu13124512 [doi]
LID - 4512
AB  - Insulin resistance (IR) is a hallmark of type 2 diabetes mellitus (T2DM). This 
      study was performed to investigate the antidiabetic effect of Bacillus toyonensis 
      SAU-19 and its possible mechanisms of action in mice with type 2 diabetes 
      mellitus (T2DM). Thirty SPFKM mice were randomly assigned to three groups: 
      control, diabetic model, and diabetes + Bacillus toyonensis SAU-19 group. After 
      35 days, blood was collected for biochemical analysis and liver tissue samples 
      for histopathological analysis using H&E staining, qPCR, and ELISA. The results 
      showed that the administration of B. toyonensis SAU-19 significantly improved the 
      blood glucose, hepatic insulin resistance, and morphological changes of the liver 
      characterized by significant improvement of dyslipidemia, glycogen synthesis, and 
      antioxidant status (p < 0.05), indicating the strains' ameliorating effects on 
      hepatic insulin resistance in T2DM. In conclusion, the probiotic strain (B. 
      toyonensis SAU-19) inhibits T2DM by reducing insulin resistance, improving 
      antioxidant status, and downregulating genes related to glucose synthesis; hence, 
      it may be used in treating diabetes and other metabolic disorders. This study 
      provides the basis for further studies into the molecular mechanisms of B. 
      toyonensis SAU-19 in treating T2DM.
FAU - Okyere, Samuel Kumi
AU  - Okyere SK
AUID- ORCID: 0000-0003-4820-8620
AD  - Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, 
      College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, 
      China.
FAU - Xie, Lei
AU  - Xie L
AD  - Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, 
      College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, 
      China.
FAU - Wen, Juan
AU  - Wen J
AD  - Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, 
      College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, 
      China.
FAU - Ran, Yinan
AU  - Ran Y
AD  - Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, 
      College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, 
      China.
FAU - Ren, Zhihua
AU  - Ren Z
AD  - Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, 
      College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, 
      China.
FAU - Deng, Junliang
AU  - Deng J
AD  - Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, 
      College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, 
      China.
FAU - Hu, Yanchun
AU  - Hu Y
AD  - Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, 
      College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, 
      China.
AD  - New Ruipeng Pet Healthcare Group Co., Ltd., Shenzhen 518000, China.
LA  - eng
GR  - 2020YFS0337/Sichuan Province Science and Technology Support Program/
PT  - Journal Article
DEP - 20211217
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - Bacillus toyonensis
SB  - IM
MH  - Animals
MH  - Bacillus/*physiology
MH  - Diabetes Mellitus, Experimental
MH  - Diabetes Mellitus, Type 2/metabolism
MH  - Diet, High-Fat/*adverse effects
MH  - Insulin Resistance/*physiology
MH  - Liver/*drug effects/metabolism
MH  - Male
MH  - Mice
MH  - Probiotics/*pharmacology
MH  - Specific Pathogen-Free Organisms
PMC - PMC8703646
OTO - NOTNLM
OT  - Bacillus toyonensis SAU-19
OT  - glucose synthesis
OT  - hepatic insulin resistance
OT  - type 2 diabetes
COIS- The authors declare no conflict of interest.
EDAT- 2021/12/29 06:00
MHDA- 2022/01/15 06:00
PMCR- 2021/12/17
CRDT- 2021/12/28 01:05
PHST- 2021/11/27 00:00 [received]
PHST- 2021/12/15 00:00 [revised]
PHST- 2021/12/15 00:00 [accepted]
PHST- 2021/12/28 01:05 [entrez]
PHST- 2021/12/29 06:00 [pubmed]
PHST- 2022/01/15 06:00 [medline]
PHST- 2021/12/17 00:00 [pmc-release]
AID - nu13124512 [pii]
AID - nutrients-13-04512 [pii]
AID - 10.3390/nu13124512 [doi]
PST - epublish
SO  - Nutrients. 2021 Dec 17;13(12):4512. doi: 10.3390/nu13124512.