PMID- 34960095 OWN - NLM STAT- MEDLINE DCOM- 20220110 LR - 20221207 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 13 IP - 12 DP - 2021 Dec 18 TI - Inverse Association of Plasma Molybdenum with Metabolic Syndrome in a Chinese Adult Population: A Case-Control Study. LID - 10.3390/nu13124544 [doi] LID - 4544 AB - Molybdenum has been found to be associated with metabolic disorders. However, the relationship between molybdenum and metabolic syndrome (MetS) is still unclear. A large case-control study was conducted in a Chinese population from the baseline of Ezhou-Shenzhen cohort. A total of 5356 subjects were included with 2678 MetS and 2678 controls matched by sex and age (+/-2 years). Medians (IQRs) of plasma molybdenum concentrations were 1.24 mug/L for MetS cases and 1.46 mug/L for controls. After adjustment for multiple covariates, the odds ratio (OR) and 95% confidence intervals (CIs) for MetS were 1.00 (reference), 0.71 (0.59-0.84), 0.56 (0.46-0.68), and 0.47 (0.39-0.58) across quartiles of plasma molybdenum, and per SD increment of log-transformed molybdenum was associated with a 23% lower risk of MetS. In the spline analysis, the risk of MetS and its components decreased steeply with increasing molybdenum and followed by a plateau when the cutoff point was observed around 2.0 mug/L. The dose-dependent relationship of molybdenum with MetS remained consistent when considering other essential elements in the Bayesian kernel machine regression (BKMR) model. In our study, higher plasma molybdenum was significantly associated with a lower risk of MetS, as well as its components, in a dose-response manner. FAU - Li, Ben AU - Li B AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. AD - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Huang, Yue AU - Huang Y AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. AD - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Luo, Cheng AU - Luo C AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. AD - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Peng, Xiaolin AU - Peng X AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. AD - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. AD - Department of Non-Communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518000, China. FAU - Jiao, Yang AU - Jiao Y AD - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Zhou, Li AU - Zhou L AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. AD - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Yin, Jiawei AU - Yin J AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. AD - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Liu, Liegang AU - Liu L AUID- ORCID: 0000-0002-7029-1224 AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. AD - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. LA - eng GR - NSFC 81820108027/the Major International (Regional) Joint Research Project/ GR - 2020YFC2006300/the National Key Research and Development Program of China/ GR - 81773423 and 21537001/the National Natural Science Foundation of China/ PT - Journal Article DEP - 20211218 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - 0 (Coenzymes) RN - 81AH48963U (Molybdenum) SB - IM MH - Adult MH - Age Factors MH - Asian People MH - Biomarkers/blood MH - Case-Control Studies MH - Coenzymes/*blood/physiology MH - Cohort Studies MH - Female MH - Humans MH - Male MH - Metabolic Syndrome/*diagnosis/*etiology/metabolism MH - Middle Aged MH - Molybdenum/*blood/physiology MH - Risk PMC - PMC8707707 OTO - NOTNLM OT - case-control study OT - dose-response relationship OT - metabolic syndrome OT - molybdenum COIS- The authors declare no conflict of interest. EDAT- 2021/12/29 06:00 MHDA- 2022/01/11 06:00 PMCR- 2021/12/18 CRDT- 2021/12/28 01:05 PHST- 2021/09/28 00:00 [received] PHST- 2021/12/14 00:00 [revised] PHST- 2021/12/15 00:00 [accepted] PHST- 2021/12/28 01:05 [entrez] PHST- 2021/12/29 06:00 [pubmed] PHST- 2022/01/11 06:00 [medline] PHST- 2021/12/18 00:00 [pmc-release] AID - nu13124544 [pii] AID - nutrients-13-04544 [pii] AID - 10.3390/nu13124544 [doi] PST - epublish SO - Nutrients. 2021 Dec 18;13(12):4544. doi: 10.3390/nu13124544.