PMID- 34961319
OWN - NLM
STAT- MEDLINE
DCOM- 20220318
LR  - 20220318
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 14
IP  - 1
DP  - 2022 Jan 12
TI  - Metal Phenolic Nanodressing of Porous Polymer Scaffolds for Enhanced Bone 
      Regeneration via Interfacial Gating Growth Factor Release and Stem Cell 
      Differentiation.
PG  - 268-277
LID - 10.1021/acsami.1c19633 [doi]
AB  - Porous polymer scaffolds are essential materials for tissue engineering because 
      they can be easily processed to deliver stem cells or bioactive factors. However, 
      scaffolds made of synthetic polymers normally lack a bioactive cell-material 
      interface and undergo a burst release of growth factors, which may hinder their 
      further application in tissue engineering. In this paper, a metal-phenolic 
      network (MPN) was interfacially constructed on the pore surface of a porous 
      poly(dl-lactide) (PPLA) scaffold. Based on the molecular gating property of the 
      MPN supramolecular structure, the PPLA@MPN scaffold achieved the sustained 
      release of the loaded molecules. In addition, the MPN coating provided a 
      bioactive interface, thus encouraging the migration and osteogenic 
      differentiation of bone marrow mesenchymal stem cells (BMSCs). The PPLA@MPN 
      scaffolds exhibited enhanced bone regeneration in a rat femoral defect model in 
      vivo compared to PPLA, which is ascribed to the combined effect of sustained bone 
      morphogenetic protein-2 (BMP-2) release and the osteogenic ability of MPN. This 
      nanodressing technique provides a viable and straightforward strategy for 
      enhancing the performance of porous polymer scaffolds in bone tissue engineering.
FAU - Zhang, Yaping
AU  - Zhang Y
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration, Jinan 250012, China.
FAU - Li, Kai
AU  - Li K
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration, Jinan 250012, China.
FAU - Shen, Lanbo
AU  - Shen L
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration, Jinan 250012, China.
FAU - Yu, Lu
AU  - Yu L
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration, Jinan 250012, China.
FAU - Ding, Tian
AU  - Ding T
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration, Jinan 250012, China.
FAU - Ma, Baojin
AU  - Ma B
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration, Jinan 250012, China.
FAU - Ge, Shaohua
AU  - Ge S
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration, Jinan 250012, China.
FAU - Li, Jianhua
AU  - Li J
AUID- ORCID: 0000-0001-5227-8627
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration, Jinan 250012, China.
LA  - eng
PT  - Journal Article
DEP - 20211228
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Biocompatible Materials)
RN  - 0 (Phenols)
RN  - 0 (Polymers)
RN  - 789U1901C5 (Copper)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/chemistry/*pharmacology
MH  - Bone Regeneration/*drug effects
MH  - Cell Differentiation/drug effects
MH  - Copper/chemistry/*pharmacology
MH  - Male
MH  - Materials Testing
MH  - Nanoparticles/chemistry
MH  - Particle Size
MH  - Phenols/chemistry/*pharmacology
MH  - Polymers/chemistry/*pharmacology
MH  - Porosity
MH  - Rats
MH  - Rats, Wistar
MH  - Stem Cells/*drug effects
MH  - Surface Properties
MH  - Tissue Scaffolds/chemistry
OTO - NOTNLM
OT  - bioactive interface
OT  - metal-phenolic network
OT  - stem cell
OT  - sustained release
OT  - tissue engineering
EDAT- 2021/12/29 06:00
MHDA- 2022/03/19 06:00
CRDT- 2021/12/28 05:30
PHST- 2021/12/29 06:00 [pubmed]
PHST- 2022/03/19 06:00 [medline]
PHST- 2021/12/28 05:30 [entrez]
AID - 10.1021/acsami.1c19633 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2022 Jan 12;14(1):268-277. doi: 
      10.1021/acsami.1c19633. Epub 2021 Dec 28.