PMID- 34963463
OWN - NLM
STAT- MEDLINE
DCOM- 20211230
LR  - 20220107
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Dec 28
TI  - Visual outcomes and choroidal thickness associated with human leukocyte antigen 
      DRB1*04 in unclassifiable uveitis in Japanese patients.
PG  - 457
LID - 10.1186/s12886-021-02222-9 [doi]
LID - 457
AB  - PURPOSE: Human leukocyte antigen (HLA) and immunity are related. Uveitis is also 
      closely related to immunity. For example, the common presence of human leukocyte 
      antigen (HLA)-DRB1*04 in the immune response is well known. The aim of this study 
      was to investigate the relationship between visual prognosis and various HLA 
      alleles before and after therapy in patients with unclassifiable uveitis, 
      excluding those with Vogt-Koyanagi-Harada (VKH) disease. METHODS: This 
      retrospective case series included 42 eyes from 22 consecutive patients with 
      unclassifiable uveitis, excluding those with VKH disease. Visual acuity (VA), 
      sex, refractive error, central retinal thickness (CRT), central choroidal 
      thickness (CCT), and duration from onset to treatment were measured at initial 
      and 6-month visits. Mean values of parameters were compared at each visit. 
      Genotyping was performed by polymerase chain reaction amplification with 
      sequence-specific primers. RESULTS: DRB1*04 showed a dominant change. No 
      significant difference was observed in the other alleles. In DRB1*04, The mean 
      differences in initial CCT, 6-month CCT, and 6-month VA showed statistically 
      significant difference was found in best-corrected visual acuity (BCVA) between 
      DRB1*04+ and DRB1*04- at the first visit. BCVA values at baseline and at the 
      final visit were 0.13 +/- 0.29 and 0.20 +/- 0.36 in the DRB1*04+ and 0.00045 +/- 0.20 
      and - 0.058 +/- 0.11 in the DRB1*04- groups(p = 0.00465). Central Choroidal 
      Thickness (CCT) values pretreatment and at the final visit after treatment were 
      (pretreatment:361.00 +/- 361.0 mum,after treatment: 286.00 +/- 106.53 mum, p = 0.0174) 
      in the DRB1*04+ group, and (pretreatment:281.3 +/- 139.68 mum,after 
      treatment:223.85 +/- 99.034 mum, p = 0.0426) in the DRB1*04- group, respectively, 
      indicating changes between baseline and the final visit. CCT was significantly 
      greater in the DRB1*04+ group at both the initial visit and at 6 months. 
      Multivariate analysis showed a significant difference between the presence or 
      absence of DRB1*04 and sex. CONCLUSION: HLA-DRB1*04 allele may affect visual 
      prognosis and CCT in unclassifiable uveitis.
CI  - (c) 2021. The Author(s).
FAU - Misawa, Norihiko
AU  - Misawa N
AD  - Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, 
      Osaka City University, 1-5-7 Asahimachi, Abeno-ku, Osaka-shi, Osaka, 545-8586, 
      Japan.
FAU - Tagami, Mizuki
AU  - Tagami M
AD  - Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, 
      Osaka City University, 1-5-7 Asahimachi, Abeno-ku, Osaka-shi, Osaka, 545-8586, 
      Japan. tagami.mizuki@med.osaka-cu.ac.jp.
FAU - Sakai, Atsushi
AU  - Sakai A
AD  - Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, 
      Osaka City University, 1-5-7 Asahimachi, Abeno-ku, Osaka-shi, Osaka, 545-8586, 
      Japan.
FAU - Kohno, Takeya
AU  - Kohno T
AD  - Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, 
      Osaka City University, 1-5-7 Asahimachi, Abeno-ku, Osaka-shi, Osaka, 545-8586, 
      Japan.
FAU - Honda, Shigeru
AU  - Honda S
AD  - Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, 
      Osaka City University, 1-5-7 Asahimachi, Abeno-ku, Osaka-shi, Osaka, 545-8586, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20211228
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - *Choroid
MH  - HLA-DRB1 Chains/genetics
MH  - Humans
MH  - Japan/epidemiology
MH  - Retrospective Studies
MH  - *Uveomeningoencephalitic Syndrome/genetics
PMC - PMC8715637
OTO - NOTNLM
OT  - Asian patients
OT  - HLA-DRB1*04
OT  - Human leukocyte antigen
OT  - Non-infectious uveitis
OT  - Unclassifiable uveitis
OT  - Visual acuity
COIS- The authors declare that they have no competing interests.
EDAT- 2021/12/30 06:00
MHDA- 2021/12/31 06:00
PMCR- 2021/12/28
CRDT- 2021/12/29 05:24
PHST- 2021/05/04 00:00 [received]
PHST- 2021/12/15 00:00 [accepted]
PHST- 2021/12/29 05:24 [entrez]
PHST- 2021/12/30 06:00 [pubmed]
PHST- 2021/12/31 06:00 [medline]
PHST- 2021/12/28 00:00 [pmc-release]
AID - 10.1186/s12886-021-02222-9 [pii]
AID - 2222 [pii]
AID - 10.1186/s12886-021-02222-9 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2021 Dec 28;21(1):457. doi: 10.1186/s12886-021-02222-9.