PMID- 34965908
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20220314
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 36
IP  - 2
DP  - 2022 Feb
TI  - Time to develop chronic kidney disease in an Ecuadorian Type 2 Diabetes Mellitus 
      cohort: Survival analysis in primary care.
PG  - 108108
LID - S1056-8727(21)00332-9 [pii]
LID - 10.1016/j.jdiacomp.2021.108108 [doi]
AB  - Chronic Kidney Disease (CKD) represents a high burden to health systems. However, 
      the survival time for CKD in a Type 2 Diabetes Mellitus (T2DM) population is 
      unknown. AIMS: Determine the risk factors, survival time and the incidence rate 
      of CKD in T2DM. METHODS: Retrospective clinical cohort study (follow up 
      10 years). 513 patients with T2DM were included. Numerical variables were 
      compared using the mean difference. Chi squared and odds ratios were calculated 
      for categorical variables. Survival analysis was done through life tables and 
      Kaplan-Meier. RESULTS: The mean difference between the group that developed CKD 
      and those who did not, was significant in: age, age at diagnosis of T2DM and 
      years with T2DM. Risk factors for developing CKD were: the presence of 
      hypertension, albuminuria, retinopathy, high triglycerides and high HbA1c. The 
      incidence rate was 32.07 per 1000 person-years of follow-up and 207 (40.4%) of 
      patients developed CKD during the study. The median for developing CKD was 
      20.52 years of disease with an increasing risk with time. CONCLUSIONS: Half of 
      the patients with T2DM will develop CKD by the second decade of disease. Time, 
      arterial hypertension, retinopathy, albuminuria and triglycerides are factors 
      associated with CKD in patients with T2DM.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Carrasco-Tenezaca, Felipe
AU  - Carrasco-Tenezaca F
AD  - Pontifical Catholic University of Ecuador, College of Medicine, 1076, 12 de 
      Octubre Avenue, Quito 170143, Pichincha, Ecuador. Electronic address: 
      fjcarrascot.rot@gmail.com.
FAU - Barrera-Guarderas, Francisco
AU  - Barrera-Guarderas F
AD  - Pontifical Catholic University of Ecuador, College of Medicine, 1076, 12 de 
      Octubre Avenue, Quito 170143, Pichincha, Ecuador. Electronic address: 
      jfbarrera@puce.edu.ec.
FAU - De la Torre-Cisneros, Katherine
AU  - De la Torre-Cisneros K
AD  - Seoul National University Graduate School, Department of Biomedical Science, 103 
      Daehak-Ro Jongno-Gu, Seoul 03080, Republic of Korea.
FAU - Medina-Escudero, Miguel
AU  - Medina-Escudero M
AD  - Pontifical Catholic University of Ecuador, College of Medicine, 1076, 12 de 
      Octubre Avenue, Quito 170143, Pichincha, Ecuador. Electronic address: 
      mmedina323@puce.edu.ec.
FAU - Venegas-Baca, Oscar
AU  - Venegas-Baca O
AD  - Pontifical Catholic University of Ecuador, College of Medicine, 1076, 12 de 
      Octubre Avenue, Quito 170143, Pichincha, Ecuador. Electronic address: 
      ovenegas143@puce.edu.ec.
LA  - eng
PT  - Journal Article
DEP - 20211222
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
SB  - IM
MH  - Child, Preschool
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis/epidemiology
MH  - *Diabetic Nephropathies
MH  - Ecuador/epidemiology
MH  - Humans
MH  - Primary Health Care
MH  - *Renal Insufficiency, Chronic/complications/diagnosis/epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Analysis
OTO - NOTNLM
OT  - Diabetes complications
OT  - Diabetic nephropathy
OT  - Primary care
OT  - Survival analysis
OT  - Type 2 Diabetes Mellitus
EDAT- 2021/12/31 06:00
MHDA- 2022/03/15 06:00
CRDT- 2021/12/30 05:26
PHST- 2021/09/21 00:00 [received]
PHST- 2021/11/15 00:00 [revised]
PHST- 2021/12/13 00:00 [accepted]
PHST- 2021/12/31 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2021/12/30 05:26 [entrez]
AID - S1056-8727(21)00332-9 [pii]
AID - 10.1016/j.jdiacomp.2021.108108 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2022 Feb;36(2):108108. doi: 
      10.1016/j.jdiacomp.2021.108108. Epub 2021 Dec 22.