PMID- 34965921
OWN - NLM
STAT- MEDLINE
DCOM- 20220406
LR  - 20240224
IS  - 1940-6215 (Electronic)
IS  - 1940-6207 (Print)
IS  - 1940-6215 (Linking)
VI  - 15
IP  - 3
DP  - 2022 Mar 1
TI  - Weight is More Informative than Body Mass Index for Predicting Postmenopausal 
      Breast Cancer Risk: Prospective Family Study Cohort (ProF-SC).
PG  - 185-191
LID - 10.1158/1940-6207.CAPR-21-0164 [doi]
AB  - We considered whether weight is more informative than body mass index (BMI) = 
      weight/height2 when predicting breast cancer risk for postmenopausal women, and 
      if the weight association differs by underlying familial risk. We studied 6,761 
      women postmenopausal at baseline with a wide range of familial risk from 2,364 
      families in the Prospective Family Study Cohort. Participants were followed for 
      on average 11.45 years and there were 416 incident breast cancers. We used Cox 
      regression to estimate risk associations with log-transformed weight and BMI 
      after adjusting for underlying familial risk. We compared model fits using the 
      Akaike information criterion (AIC) and nested models using the likelihood ratio 
      test. The AIC for the weight-only model was 6.22 units lower than for the 
      BMI-only model, and the log risk gradient was 23% greater. Adding BMI or height 
      to weight did not improve fit (DeltaAIC = 0.90 and 0.83, respectively; both P = 0.3). 
      Conversely, adding weight to BMI or height gave better fits (DeltaAIC = 5.32 and 
      11.64; P = 0.007 and 0.0002, respectively). Adding height improved only the BMI 
      model (DeltaAIC = 5.47; P = 0.006). There was no evidence that the BMI or weight 
      associations differed by underlying familial risk (P > 0.2). Weight is more 
      informative than BMI for predicting breast cancer risk, consistent with 
      nonadipose as well as adipose tissue being etiologically relevant. The 
      independent but multiplicative associations of weight and familial risk suggest 
      that, in terms of absolute breast cancer risk, the association with weight is 
      more important the greater a woman's underlying familial risk. PREVENTION 
      RELEVANCE: Our results suggest that the relationship between BMI and breast 
      cancer could be due to a relationship between weight and breast cancer, 
      downgraded by inappropriately adjusting for height; potential importance of 
      anthropometric measures other than total body fat; breast cancer risk 
      associations with BMI and weight are across a continuum.
CI  - (c)2021 The Authors; Published by the American Association for Cancer Research.
FAU - Ye, Zhoufeng
AU  - Ye Z
AUID- ORCID: 0000-0002-0884-4246
AD  - Centre for Epidemiology and Biostatistics, University of Melbourne, Parkville, 
      Victoria, Australia.
FAU - Li, Shuai
AU  - Li S
AD  - Centre for Epidemiology and Biostatistics, University of Melbourne, Parkville, 
      Victoria, Australia.
AD  - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary 
      Care, University of Cambridge, Cambridge, United Kingdom.
AD  - Precision Medicine, School of Clinical Sciences at Monash Health, Monash 
      University, Clayton, Victoria, Australia.
FAU - Dite, Gillian S
AU  - Dite GS
AUID- ORCID: 0000-0002-2448-2548
AD  - Centre for Epidemiology and Biostatistics, University of Melbourne, Parkville, 
      Victoria, Australia.
AD  - Genetic Technologies Limited, Fitzroy, Victoria, Australia.
FAU - Nguyen, Tuong L
AU  - Nguyen TL
AUID- ORCID: 0000-0002-6597-8363
AD  - Centre for Epidemiology and Biostatistics, University of Melbourne, Parkville, 
      Victoria, Australia.
FAU - MacInnis, Robert J
AU  - MacInnis RJ
AD  - Centre for Epidemiology and Biostatistics, University of Melbourne, Parkville, 
      Victoria, Australia.
AD  - Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, 
      Australia.
FAU - Andrulis, Irene L
AU  - Andrulis IL
AD  - Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, 
      University of Toronto, Toronto, Ontario, Canada.
AD  - Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, 
      Canada.
FAU - Buys, Saundra S
AU  - Buys SS
AUID- ORCID: 0000-0003-4120-5697
AD  - Department of Medicine and Huntsman Cancer Institute, University of Utah Health 
      Sciences Center, Salt Lake City, Utah.
FAU - Daly, Mary B
AU  - Daly MB
AD  - Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, 
      Pennsylvania.
FAU - John, Esther M
AU  - John EM
AUID- ORCID: 0000-0003-3259-8003
AD  - Department of Epidemiology and Population Health, Stanford University School of 
      Medicine, Stanford, California.
FAU - Kurian, Allison W
AU  - Kurian AW
AUID- ORCID: 0000-0002-6175-9470
AD  - Department of Medicine (Oncology), Stanford University School of Medicine, 
      Stanford, California.
FAU - Genkinger, Jeanine M
AU  - Genkinger JM
AUID- ORCID: 0000-0002-8438-0412
AD  - Department of Epidemiology, Mailman School of Public Health, Columbia University, 
      New York City, New York.
AD  - Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 
      New York City, New York.
FAU - Chung, Wendy K
AU  - Chung WK
AD  - Department of Epidemiology, Mailman School of Public Health, Columbia University, 
      New York City, New York.
AD  - Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 
      New York City, New York.
AD  - Departments of Pediatrics and Medicine, Columbia University, New York City, New 
      York.
FAU - Phillips, Kelly-Anne
AU  - Phillips KA
AUID- ORCID: 0000-0002-0475-1771
AD  - Centre for Epidemiology and Biostatistics, University of Melbourne, Parkville, 
      Victoria, Australia.
AD  - Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 
      Victoria, Australia.
AD  - Sir Peter MacCallum Department of Oncology, The University of Melbourne, 
      Melbourne, Victoria, Australia.
FAU - Thorne, Heather
AU  - Thorne H
AD  - Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, 
      Australia.
FAU - Winship, Ingrid M
AU  - Winship IM
AD  - Department of Medicine, The University of Melbourne, Melbourne, Victoria, 
      Australia.
FAU - Milne, Roger L
AU  - Milne RL
AUID- ORCID: 0000-0001-5764-7268
AD  - Centre for Epidemiology and Biostatistics, University of Melbourne, Parkville, 
      Victoria, Australia.
AD  - Precision Medicine, School of Clinical Sciences at Monash Health, Monash 
      University, Clayton, Victoria, Australia.
AD  - Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, 
      Australia.
FAU - Dugue, Pierre-Antoine
AU  - Dugue PA
AUID- ORCID: 0000-0003-2736-3023
AD  - Centre for Epidemiology and Biostatistics, University of Melbourne, Parkville, 
      Victoria, Australia.
AD  - Precision Medicine, School of Clinical Sciences at Monash Health, Monash 
      University, Clayton, Victoria, Australia.
AD  - Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, 
      Australia.
FAU - Southey, Melissa C
AU  - Southey MC
AUID- ORCID: 0000-0002-6313-9005
AD  - Precision Medicine, School of Clinical Sciences at Monash Health, Monash 
      University, Clayton, Victoria, Australia.
AD  - Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, 
      Australia.
AD  - Department of Clinical Pathology, The Melbourne Medical School, The University of 
      Melbourne, Melbourne, Australia.
FAU - Giles, Graham G
AU  - Giles GG
AUID- ORCID: 0000-0003-4946-9099
AD  - Centre for Epidemiology and Biostatistics, University of Melbourne, Parkville, 
      Victoria, Australia.
AD  - Precision Medicine, School of Clinical Sciences at Monash Health, Monash 
      University, Clayton, Victoria, Australia.
AD  - Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, 
      Australia.
FAU - Terry, Mary Beth
AU  - Terry MB
AD  - Department of Epidemiology, Mailman School of Public Health, Columbia University, 
      New York City, New York.
AD  - Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 
      New York City, New York.
FAU - Hopper, John L
AU  - Hopper JL
AD  - Centre for Epidemiology and Biostatistics, University of Melbourne, Parkville, 
      Victoria, Australia.
LA  - eng
GR  - R01 CA159868/CA/NCI NIH HHS/United States
GR  - U01 CA164920/CA/NCI NIH HHS/United States
GR  - UM1 CA164920/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Prev Res (Phila)
JT  - Cancer prevention research (Philadelphia, Pa.)
JID - 101479409
SB  - IM
MH  - Body Mass Index
MH  - Body Weight
MH  - *Breast Neoplasms/diagnosis/epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Postmenopause
MH  - Prospective Studies
MH  - Risk Factors
PMC - PMC8977841
MID - NIHMS1768528
EDAT- 2021/12/31 06:00
MHDA- 2022/04/07 06:00
PMCR- 2022/11/14
CRDT- 2021/12/30 05:26
PHST- 2021/04/15 00:00 [received]
PHST- 2021/05/17 00:00 [revised]
PHST- 2021/12/20 00:00 [accepted]
PHST- 2021/12/31 06:00 [pubmed]
PHST- 2022/04/07 06:00 [medline]
PHST- 2021/12/30 05:26 [entrez]
PHST- 2022/11/14 00:00 [pmc-release]
AID - 1940-6207.CAPR-21-0164 [pii]
AID - CAPR-21-0164 [pii]
AID - 10.1158/1940-6207.CAPR-21-0164 [doi]
PST - ppublish
SO  - Cancer Prev Res (Phila). 2022 Mar 1;15(3):185-191. doi: 
      10.1158/1940-6207.CAPR-21-0164.