PMID- 34966302
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211231
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 12
DP  - 2021
TI  - Decreased Medial Prefrontal Cortex Glutamate Levels in Perimenopausal Women.
PG  - 763562
LID - 10.3389/fpsyt.2021.763562 [doi]
LID - 763562
AB  - Objective: There is an increased risk of experiencing depression during 
      perimenopause (PM), a period of rapidly changing female hormone concentrations. 
      Women at particular risk of developing major depression (MD) during PM are those 
      with history of mood sensitivity to female hormone fluctuations i.e., women with 
      a history of premenstrual dysphoric disorder (PMDD) and/or post-partum depression 
      (PPD). Depressive symptomology has been associated with fluctuations of glutamate 
      (Glu) levels in the medial prefrontal cortex (MPFC) in MD patients as well as 
      PMDD and PPD patients. The objective of the study was to compare MPFC Glu levels 
      in healthy perimenopausal and reproductive-aged (RD) women. Methods: Medial 
      prefrontal cortex Glu levels in healthy perimenopausal (n = 15) and healthy RD 
      women (n = 16) were compared via Magnetic Resonance Spectroscopy (MRS) scan using 
      a 3 Tesla (T) magnet. Absence of depressive symptomology and psychiatric 
      comorbidity was confirmed via semi-structured interview. Participants were 
      scanned during the early follicular phase (FP) of the menstrual cycle (MC). 
      Results: Mean MPFC Glu concentrations were decreased in the PM group compared to 
      RD group (PM mean = 0.57 +/- 0.03, RD mean = 0.63 +/- 0.06, t = -3.84, df = 23.97, p 
      = 0.001). Conclusion: Perimenopause is associated with decreases in MPFC Glu 
      levels. This decrease may be contributing to the increased risk of experiencing 
      depression during PM. Further research should assess MPFC Glu levels in 
      perimenopausal women suffering from MD.
CI  - Copyright (c) 2021 Yap, Luki, Hanstock, Seres, Shandro, Hanstock, Lirette, Zhao, 
      Aitchison and Le Melledo.
FAU - Yap, Sidney
AU  - Yap S
AD  - Department of Psychiatry, University of Alberta, Edmonton, AB, Canada.
FAU - Luki, Jessica
AU  - Luki J
AD  - Department of Psychiatry, University of Alberta, Edmonton, AB, Canada.
FAU - Hanstock, Christopher C
AU  - Hanstock CC
AD  - Department of Biomedical Engineering, University of Alberta, Edmonton, AB, 
      Canada.
FAU - Seres, Peter
AU  - Seres P
AD  - Department of Biomedical Engineering, University of Alberta, Edmonton, AB, 
      Canada.
FAU - Shandro, Tami
AU  - Shandro T
AD  - Lois Hole Hospital for Women, Royal Alexandra Hospital, Edmonton, AB, Canada.
FAU - Hanstock, Sarah E C
AU  - Hanstock SEC
AD  - Department of Psychiatry, University of Alberta, Edmonton, AB, Canada.
FAU - Lirette, Alynna
AU  - Lirette A
AD  - Department of Psychiatry, University of Alberta, Edmonton, AB, Canada.
FAU - Zhao, Huaying Helen
AU  - Zhao HH
AD  - Department of Psychiatry, University of Alberta, Edmonton, AB, Canada.
FAU - Aitchison, Katherine J
AU  - Aitchison KJ
AD  - Department of Psychiatry, University of Alberta, Edmonton, AB, Canada.
AD  - Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada.
AD  - The Neuroscience and Mental Health Institute, University of Alberta, Edmonton, 
      AB, Canada.
AD  - Edmonton Mood and Anxiety Disorders Program, University of Alberta Hospital, 
      Edmonton, AB, Canada.
FAU - Le Melledo, Jean-Michel
AU  - Le Melledo JM
AD  - Department of Psychiatry, University of Alberta, Edmonton, AB, Canada.
LA  - eng
PT  - Journal Article
DEP - 20211213
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC8710490
OTO - NOTNLM
OT  - depression
OT  - glutamate
OT  - magnetic resonance spectroscopy - MRS
OT  - medial prefrontal cortex
OT  - perimenopause
COIS- KA declares receipt of two fellowship grants from Janssen Inc., Canada. The 
      remaining authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/31 06:00
MHDA- 2021/12/31 06:01
PMCR- 2021/12/13
CRDT- 2021/12/30 05:37
PHST- 2021/08/24 00:00 [received]
PHST- 2021/10/27 00:00 [accepted]
PHST- 2021/12/30 05:37 [entrez]
PHST- 2021/12/31 06:00 [pubmed]
PHST- 2021/12/31 06:01 [medline]
PHST- 2021/12/13 00:00 [pmc-release]
AID - 10.3389/fpsyt.2021.763562 [doi]
PST - epublish
SO  - Front Psychiatry. 2021 Dec 13;12:763562. doi: 10.3389/fpsyt.2021.763562. 
      eCollection 2021.