PMID- 34967298
OWN - NLM
STAT- MEDLINE
DCOM- 20220617
LR  - 20220707
IS  - 1875-6417 (Electronic)
IS  - 1573-3998 (Linking)
VI  - 18
IP  - 9
DP  - 2022
TI  - Environmental Factors as Diabetic Mediators: A Mechanistic Approach.
PG  - e301221199656
LID - 10.2174/1573399818666211230104327 [doi]
AB  - Despite substantial investment in research and treatment options, diabetes 
      mellitus remains a pressing public health concern with potential epidemic 
      proportions globally. There are reports that by the end of 2040, 642 million 
      people will be suffering from diabetes. Also, according to an estimation, 1.6 
      million deaths were caused directly by diabetes in 2016. Diabetes is a metabolic 
      disorder characterized by impaired glucose regulation in the body due to the 
      destruction of pancreatic beta-cells or insulin resistance. Genetic propensity, 
      unhealthy and imbalanced diet, obesity and increasing urbanization are the common 
      risk factors for diabetes. Besides this, it has been reported that environmental 
      pollutants like organic pesticides, heavy metals, and air pollutants act as 
      strong predisposing factors for diabetes owing to their highly bio-accumulative 
      nature. These pollutants disturb glucose homeostasis either by up-regulating or 
      down-regulating the expression of diabetic marker genes like insulin (INS) and 
      glucokinase (GCK). Unfortunately, the molecular mechanism of the role of 
      pollutants in causing diabetes is not very clear. This mechanistic review 
      provides evidence of different environmental determinants, including persistent 
      organic pollutants (POPs), air pollutants, toxic metals, etc., in inducing 
      diabetes and proposes a framework for the possible mechanisms involved. It also 
      illuminates the current status and future challenges, which will not only broaden 
      our understanding but can also be a reasonable platform for further 
      investigation.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Firdous, Parveena
AU  - Firdous P
AD  - Centre of Research for Development (CORD), University of Kashmir, Srinagar, Jammu 
      and Kashmir 190006, India.
FAU - Nissar, Kamran
AU  - Nissar K
AD  - Centre of Research for Development (CORD), University of Kashmir, Srinagar, Jammu 
      and Kashmir 190006, India.
AD  - Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir 
      190006, India.
AD  - Department of Clinical Biochemistry, University of Kashmir, Srinagar, Jammu and 
      Kashmir 190006, India.
FAU - Bashir, Humayra
AU  - Bashir H
AD  - Centre of Research for Development (CORD), University of Kashmir, Srinagar, Jammu 
      and Kashmir 190006, India.
FAU - Hussain, Qazi A
AU  - Hussain QA
AD  - P.G. Department of Environmental Science, Sri Pratap College Campus, Cluster 
      University Srinagar, Jammu and Kashmir 190001, India.
FAU - Masoodi, Shariq Rashid
AU  - Masoodi SR
AD  - Department of Endocrinology, SKIMS, Srinagar Jammu and Kashmir 190011, India.
FAU - Ganai, Bashir Ahmad
AU  - Ganai BA
AD  - Centre of Research for Development (CORD), University of Kashmir, Srinagar, Jammu 
      and Kashmir 190006, India.
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Diabetes Rev
JT  - Current diabetes reviews
JID - 101253260
RN  - 0 (Air Pollutants)
RN  - 0 (Environmental Pollutants)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - *Air Pollutants
MH  - *Diabetes Mellitus/epidemiology/etiology
MH  - *Environmental Pollutants/toxicity
MH  - Glucose
MH  - Humans
MH  - *Insulin Resistance/physiology
OTO - NOTNLM
OT  - Diabetes
OT  - air pollutants
OT  - environmental factors
OT  - metals
OT  - open green space.
OT  - organic pollutants
EDAT- 2021/12/31 06:00
MHDA- 2022/06/18 06:00
CRDT- 2021/12/30 08:41
PHST- 2021/07/27 00:00 [received]
PHST- 2021/09/13 00:00 [revised]
PHST- 2021/09/29 00:00 [accepted]
PHST- 2021/12/31 06:00 [pubmed]
PHST- 2022/06/18 06:00 [medline]
PHST- 2021/12/30 08:41 [entrez]
AID - CDR-EPUB-119784 [pii]
AID - 10.2174/1573399818666211230104327 [doi]
PST - ppublish
SO  - Curr Diabetes Rev. 2022;18(9):e301221199656. doi: 
      10.2174/1573399818666211230104327.