PMID- 34967779
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20220916
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 68
IP  - 9
DP  - 2022 Sep 1
TI  - Adverse Events Associated with Cardiac Catheterization in Children Supported with 
      Ventricular Assist Devices.
PG  - 1174-1181
LID - 10.1097/MAT.0000000000001627 [doi]
AB  - Children on ventricular assist device (VAD) support can present several unique 
      challenges, including small patient size, univentricular or biventricular 
      congenital heart disease (1V- or 2V-CHD) and need for biventricular VAD (BiVAD) 
      support. While cardiac catheterization can provide valuable information, it is an 
      invasive procedure with inherent risks. We sought to evaluate the safety of 
      catheterization in pediatric patients on VAD support. We performed a 
      retrospective review of patients on VAD support who underwent catheterization at 
      Lucile Packard Children's Hospital between January 1, 2014 and September 1, 2019. 
      Using definitions adapted from Pedimacs, adverse events (AEs) after 
      catheterization were identified, including arrhythmia; major bleeding or acute 
      kidney injury within 24 hours; respiratory failure persisting at 24 hours; and 
      stroke, pericardial effusion, device malfunction, bacteremia or death within 7 
      days. AEs were categorized as related or unrelated to catheterization. Sixty 
      procedures were performed on 39 patients. Underlying diagnoses were dilated 
      cardiomyopathy (48%), 1V-CHD (35%), 2V-CHD (8%), and other (8%). Devices were 
      implantable continuous flow (72%), paracorporeal pulsatile (18%) and 
      paracorporeal continuous flow (10%). Catheterizations were performed on patients 
      in the ICU (60%), on inotropic support (42%), with deteriorating clinical status 
      (37%) and on BiVAD support (12%). There were 9 AEs possibly related to 
      catheterization including 6 episodes of respiratory failure, 2 major bleeding 
      events, and 1 procedural arrhythmia. AE occurrence was associated with ICU status 
      ( P = 0.01), BiVAD support ( P = 0.04) and procedural indication to evaluate 
      worsening clinical status ( P = 0.04). Despite high medical acuity, 
      catheterization can be performed with an acceptable AE profile in children on VAD 
      support.
CI  - Copyright (c) ASAIO 2021.
FAU - Power, Alyssa
AU  - Power A
AUID- ORCID: 0000-0002-3627-6848
AD  - From the Department of Pediatrics, UT Southwestern Medical Center and Children's 
      Medical Center, Dallas, Texas, USA.
FAU - Navaratnam, Manchula
AU  - Navaratnam M
AUID- ORCID: 0000-0001-6524-6640
AD  - Department of Anesthesia, Lucile Salter Packard Children's Hospital and Stanford 
      University Hospital, Palo Alto, California, USA.
FAU - Murray, Jenna M
AU  - Murray JM
AD  - Lucile Salter Packard Children's Hospital, Palo Alto, California, USA.
FAU - Peng, Lynn F
AU  - Peng LF
AD  - Department of Pediatrics, Lucile Salter Packard Children's Hospital and Stanford 
      University Hospital, Palo Alto, California, USA.
FAU - Rosenthal, David N
AU  - Rosenthal DN
AUID- ORCID: 0000-0002-6342-2759
AD  - Department of Pediatrics, Lucile Salter Packard Children's Hospital and Stanford 
      University Hospital, Palo Alto, California, USA.
FAU - Dykes, John C
AU  - Dykes JC
AD  - Department of Pediatrics, Lucile Salter Packard Children's Hospital and Stanford 
      University Hospital, Palo Alto, California, USA.
FAU - Yarlagadda, Vamsi V
AU  - Yarlagadda VV
AUID- ORCID: 0000-0003-0928-5666
AD  - Department of Pediatrics, Lucile Salter Packard Children's Hospital and Stanford 
      University Hospital, Palo Alto, California, USA.
FAU - Maeda, Katsuhide
AU  - Maeda K
AD  - Department of Cardiothoracic Surgery, Lucile Salter Packard Children's Hospital 
      and Stanford University Hospital, Palo Alto, California, USA.
FAU - Almond, Christopher S
AU  - Almond CS
AD  - Department of Pediatrics, Lucile Salter Packard Children's Hospital and Stanford 
      University Hospital, Palo Alto, California, USA.
FAU - Chen, Sharon
AU  - Chen S
AUID- ORCID: 0000-0002-0576-0856
AD  - Department of Pediatrics, Lucile Salter Packard Children's Hospital and Stanford 
      University Hospital, Palo Alto, California, USA.
LA  - eng
PT  - Journal Article
DEP - 20211228
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
MH  - Cardiac Catheterization/adverse effects
MH  - Child
MH  - *Heart Failure/diagnosis/surgery
MH  - *Heart-Assist Devices/adverse effects
MH  - Humans
MH  - *Respiratory Insufficiency
MH  - Retrospective Studies
MH  - Treatment Outcome
COIS- Disclosure: There are no conflicts of interest to report
EDAT- 2021/12/31 06:00
MHDA- 2022/09/09 06:00
CRDT- 2021/12/30 12:44
PHST- 2021/12/31 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2021/12/30 12:44 [entrez]
AID - 00002480-202209000-00011 [pii]
AID - 10.1097/MAT.0000000000001627 [doi]
PST - ppublish
SO  - ASAIO J. 2022 Sep 1;68(9):1174-1181. doi: 10.1097/MAT.0000000000001627. Epub 2021 
      Dec 28.