PMID- 34968434
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220401
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 206
DP  - 2022 Apr 15
TI  - Association between prenatal exposure to metal mixtures and early childhood 
      allergic diseases.
PG  - 112615
LID - S0013-9351(21)01916-2 [pii]
LID - 10.1016/j.envres.2021.112615 [doi]
AB  - The association between prenatal exposure to the metal mixture and allergic 
      diseases is poorly understood. We aimed to explore the individual effect and the 
      combined effect of prenatal exposure to vanadium (V), chromium (Cr), nickel (Ni), 
      arsenic (As), cadmium (Cd), thallium (Tl), and lead (Pb) on early childhood 
      allergic diseases based on a birth cohort study that included 628 mother-infant 
      pairs. Metals were measured in maternal urine samples collected in the first, 
      second, and third trimesters. Children were prospectively followed up at age 4 
      years to collect information on allergic rhinitis, wheeze, and eczema status. By 
      applying logistic regression models, weighted quantile sum (WQS) regression, and 
      Bayesian kernel machine regression (BKMR), the different statistical analyses 
      revealed urinary metals were only associated with early childhood allergic 
      rhinitis. The averaged prenatal As exposure was significantly associated with an 
      increased OR for allergic rhinitis in both single-metal (OR = 2.04, 95% CI: 1.35, 
      3.07) and multiple-metal logistic regression models (OR = 1.78, 95% CI: 1.15, 
      2.78). The WQS index of mixed metal exposure was positively associated with 
      allergic rhinitis (OR = 1.66, 95% CI: 1.26, 2.19), and As and Tl had the largest 
      weights in the WQS index (weighted 0.51 and 0.29, respectively). The BKMR 
      analysis also showed the overall effect of the metal mixture was significantly 
      associated with allergic rhinitis when all the metals were at their 55th 
      percentile or above, compared to their 50th percentile. The effect of As and Tl 
      on the risk of allergic rhinitis was significant when all of the other metals 
      were fixed at the specific percentiles. Our findings suggest that prenatal 
      co-exposure to higher levels of the seven metals increases the risk of allergic 
      rhinitis in children, and As and Tl may contribute most to the combined risk.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Ruan, Fengyu
AU  - Ruan F
AD  - Key Laboratory of Environment and Health, Ministry of Education & Ministry of 
      Environmental Protection, and State Key Laboratory of Environmental Health, 
      School of Public Health, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, Hubei, People's Republic of China.
FAU - Zhang, Jingjing
AU  - Zhang J
AD  - Key Laboratory of Environment and Health, Ministry of Education & Ministry of 
      Environmental Protection, and State Key Laboratory of Environmental Health, 
      School of Public Health, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, Hubei, People's Republic of China.
FAU - Liu, Juan
AU  - Liu J
AD  - Key Laboratory of Environment and Health, Ministry of Education & Ministry of 
      Environmental Protection, and State Key Laboratory of Environmental Health, 
      School of Public Health, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, Hubei, People's Republic of China.
FAU - Sun, Xiaojie
AU  - Sun X
AD  - Key Laboratory of Environment and Health, Ministry of Education & Ministry of 
      Environmental Protection, and State Key Laboratory of Environmental Health, 
      School of Public Health, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, Hubei, People's Republic of China.
FAU - Li, Yuanyuan
AU  - Li Y
AD  - Key Laboratory of Environment and Health, Ministry of Education & Ministry of 
      Environmental Protection, and State Key Laboratory of Environmental Health, 
      School of Public Health, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, Hubei, People's Republic of China.
FAU - Xu, Shunqing
AU  - Xu S
AD  - Key Laboratory of Environment and Health, Ministry of Education & Ministry of 
      Environmental Protection, and State Key Laboratory of Environmental Health, 
      School of Public Health, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, Hubei, People's Republic of China.
FAU - Xia, Wei
AU  - Xia W
AD  - Key Laboratory of Environment and Health, Ministry of Education & Ministry of 
      Environmental Protection, and State Key Laboratory of Environmental Health, 
      School of Public Health, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, Hubei, People's Republic of China. Electronic address: 
      xiawei@hust.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211228
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Metals)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - *Arsenic
MH  - Bayes Theorem
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Metals/toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced/epidemiology
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - Allergy
OT  - Children
OT  - Metal mixtures
OT  - Prenatal exposure
EDAT- 2021/12/31 06:00
MHDA- 2022/04/01 06:00
CRDT- 2021/12/30 20:11
PHST- 2021/09/15 00:00 [received]
PHST- 2021/12/19 00:00 [revised]
PHST- 2021/12/20 00:00 [accepted]
PHST- 2021/12/31 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2021/12/30 20:11 [entrez]
AID - S0013-9351(21)01916-2 [pii]
AID - 10.1016/j.envres.2021.112615 [doi]
PST - ppublish
SO  - Environ Res. 2022 Apr 15;206:112615. doi: 10.1016/j.envres.2021.112615. Epub 2021 
      Dec 28.