PMID- 34970223
OWN - NLM
STAT- MEDLINE
DCOM- 20220214
LR  - 20220214
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 12
DP  - 2021
TI  - Aerobic Physical Exercise Improves Exercise Tolerance and Fasting Glycemia 
      Independent of Body Weight Change in Obese Females.
PG  - 772914
LID - 10.3389/fendo.2021.772914 [doi]
LID - 772914
AB  - Obesity is associated with increased risk of several chronic diseases and the 
      loss of disease-free years, which has increased the focus of much research for 
      the discovery of therapy to combat it. Under healthy conditions, women tend to 
      store more fat in subcutaneous deposits. However, this sexual dimorphism tends to 
      be lost in the presence of comorbidities, such as type 2 diabetes mellitus 
      (T2DM). Aerobic physical exercise (APE) has been applied in the management of 
      obesity, however, is still necessary to better understand the effects of APE in 
      obese female. Thus, we investigated the effect of APE on body weight, adiposity, 
      exercise tolerance and glucose metabolism in female ob/ob mice. Eight-weeks-old 
      female wild-type C57BL/6J and leptin-deficient ob/ob mice (Lep(ob)) were 
      distributed into three groups: wild-type sedentary group (Wt; n = 6), 
      leptin-deficient sedentary group (Lep(ob)S; n = 5) and leptin-deficient trained 
      group (Lep(ob)T; n = 8). The Lep(ob)T mice were subjected to 8 weeks of aerobic 
      physical exercise (APE) at 60% of the maximum velocity achieved in the running 
      capacity test. The APE had no effect in attenuating body weight gain, and did not 
      reduce subcutaneous and retroperitoneal white adipose tissue (SC-WAT and RP-WAT, 
      respectively) and interscapular brown adipose tissue (iBAT) weights. The APE 
      neither improved glucose intolerance nor insulin resistance in the Lep(ob)T 
      group. Also, the APE did not reduce the diameter or the area of RP-WAT 
      adipocytes, but the APE reduced the diameter and the area of SC-WAT adipocytes, 
      which was associated with lower fasting glycemia and islet/pancreas area ratio in 
      the Lep(ob)T group. In addition, the APE increased exercise tolerance and this 
      response was also associated with lower fasting glycemia in the Lep(ob)T group. 
      In conclusion, starting APE at a later age with a more severe degree of obesity 
      did not attenuate the excessive body weight gain, however the APE promoted 
      benefits that can improve the female health, and for this reason it should be 
      recommended as a non-pharmacological therapy for obesity.
CI  - Copyright (c) 2021 Boschetti, Muller, Americo, Vecchiatto, Martucci, Pereira, 
      Oliveira, Fiorino, Evangelista and Azevedo-Martins.
FAU - Boschetti, Daniela
AU  - Boschetti D
AD  - School of Arts, Science and Humanities, University of Sao Paulo, Sao Paulo, 
      Brazil.
FAU - Muller, Cynthia R
AU  - Muller CR
AD  - Department of Bioengineering, University of California San Diego, La Jolla, San 
      Diego, CA, United States.
AD  - Department of Experimental Pathophysiology, Faculty of Medicine, University of 
      Sao Paulo, Sao Paulo, Brazil.
FAU - Americo, Anna Laura V
AU  - Americo ALV
AD  - Department of Experimental Pathophysiology, Faculty of Medicine, University of 
      Sao Paulo, Sao Paulo, Brazil.
FAU - Vecchiatto, Bruno
AU  - Vecchiatto B
AD  - School of Arts, Science and Humanities, University of Sao Paulo, Sao Paulo, 
      Brazil.
AD  - Department of Experimental Pathophysiology, Faculty of Medicine, University of 
      Sao Paulo, Sao Paulo, Brazil.
FAU - Martucci, Luiz Felipe
AU  - Martucci LF
AD  - Department of Experimental Pathophysiology, Faculty of Medicine, University of 
      Sao Paulo, Sao Paulo, Brazil.
FAU - Pereira, Renata O
AU  - Pereira RO
AD  - Translational Medicine Division, Department of Medicine, Federal University of 
      Sao Paulo, Sao Paulo, Brazil.
FAU - Oliveira, Claudia P
AU  - Oliveira CP
AD  - Division of Gastroenterology and Hepatology, Department of Gastroenterology (LIM 
      07), Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
FAU - Fiorino, Patricia
AU  - Fiorino P
AD  - Renal, Cardiovascular and Metabolic Physiopharmacology Laboratory, Health and 
      Biological Science Center, Mackenzie Presbyterian University, Sao Paulo, Brazil.
FAU - Evangelista, Fabiana S
AU  - Evangelista FS
AD  - School of Arts, Science and Humanities, University of Sao Paulo, Sao Paulo, 
      Brazil.
FAU - Azevedo-Martins, Anna Karenina
AU  - Azevedo-Martins AK
AD  - School of Arts, Science and Humanities, University of Sao Paulo, Sao Paulo, 
      Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211214
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Animals
MH  - *Blood Glucose
MH  - Body Weight/*physiology
MH  - Diabetes Mellitus, Type 2/blood/physiopathology
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Mice
MH  - Obesity/blood/*physiopathology
MH  - Physical Conditioning, Animal/*physiology
PMC - PMC8713970
OTO - NOTNLM
OT  - female
OT  - insulin resistance
OT  - leptin deficiency
OT  - obesity
OT  - physical exercise
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/01/01 06:00
MHDA- 2022/02/15 06:00
PMCR- 2021/01/01
CRDT- 2021/12/31 06:02
PHST- 2021/09/08 00:00 [received]
PHST- 2021/11/18 00:00 [accepted]
PHST- 2021/12/31 06:02 [entrez]
PHST- 2022/01/01 06:00 [pubmed]
PHST- 2022/02/15 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2021.772914 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2021 Dec 14;12:772914. doi: 
      10.3389/fendo.2021.772914. eCollection 2021.