PMID- 34970857 OWN - NLM STAT- MEDLINE DCOM- 20220418 LR - 20220501 IS - 2162-3279 (Electronic) VI - 12 IP - 2 DP - 2022 Feb TI - The passive recipient: Neural correlates of negative self-view in depression. PG - e2477 LID - 10.1002/brb3.2477 [doi] LID - e2477 AB - INTRODCTION: Previous studies have argued that people tend to isolate themselves from negative information. This tendency is modulated by the individual's role in social interaction, that is, as an initiative actor (e.g., "I hit Tom") or a passive recipient (e.g., "Paul hits me"). Depressed patients tend to focus on negative aspects of themselves and cope with situations passively. It is still an open question how the actor/recipient role affects the behavioral and neural responses to self in depression. METHODS: The present study adopted functional magnetic resonance imaging (fMRI) technology to investigate behavioral and neural responses to self (as an actor/recipient) in depressed patients and the matched healthy controls when attributing negative events. RESULTS: Compared with healthy controls, depressed patients showed more self-attribution for negative events. Depressed patients showed increased brain activity in the dorsal medial prefrontal cortex (dmPFC) subsystem of the default mode network (DMN) when they played recipient role in self-related negative events. Activity of the dmPFC subsystem was negatively correlated with depressed patients' self-attribution for negative events in recipient condition. While decreased brain activity in the medial temporal lobe (MTL) subsystem was observed in depressed patients when they played the actor or recipient role in self-related negative events. Activity of the MTL subsystem was negatively correlated with depressed patients' reaction time when they played recipient role in selfrelated negative events. CONCLUSION: These results implicated that depressed patients manifested the negative self-view. Actor/recipient role affected their activation patterns in the DMN which were different from the healthy controls. The correlation between the abnormal brain activations of the DMN and the behavioral performances might manifest more easily when depressed patients played recipient role in negative events. CI - (c) 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC. FAU - Wang, Xiaoyan AU - Wang X AUID- ORCID: 0000-0002-0800-5864 AD - School of Psychology, Sichuan Normal University, Chengdu, China. AD - School of Psychology and Cognitive Science, East China Normal University, Shanghai, China. AD - National Demonstration Center for Experimental Psychology Education, East China Normal University, Shanghai, China. FAU - Li, Ping AU - Li P AUID- ORCID: 0000-0002-3241-3091 AD - Department of Psychiatry, Qiqihar Medical University, Qiqihar, China. FAU - Zheng, Li AU - Zheng L AD - School of Psychology and Cognitive Science, East China Normal University, Shanghai, China. AD - National Demonstration Center for Experimental Psychology Education, East China Normal University, Shanghai, China. FAU - Liu, Zhiyuan AU - Liu Z AD - Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China. FAU - Cui, Guangcheng AU - Cui G AD - Department of Psychiatry, Qiqihar Medical University, Qiqihar, China. FAU - Li, Lin AU - Li L AD - School of Psychology and Cognitive Science, East China Normal University, Shanghai, China. AD - National Demonstration Center for Experimental Psychology Education, East China Normal University, Shanghai, China. FAU - Zhang, Liangtang AU - Zhang L AD - Department of Psychiatry, Qiqihar Medical University, Qiqihar, China. FAU - Hu, Qiang AU - Hu Q AD - Department of Clinical Psychology, Qiqihar Mental Health Center, Qiqihar, China. FAU - Guo, Yu AU - Guo Y AD - Department of Clinical Psychology, Qiqihar Mental Health Center, Qiqihar, China. FAU - Wan, Lu AU - Wan L AD - Department of Clinical Psychology, Qiqihar Mental Health Center, Qiqihar, China. FAU - Li, Chengchong AU - Li C AD - Department of Psychiatry, Qiqihar Medical University, Qiqihar, China. FAU - Chen, Yunhui AU - Chen Y AD - Department of Psychiatry, Qiqihar Medical University, Qiqihar, China. FAU - Sun, Zhenghai AU - Sun Z AD - Department of Psychiatry, Qiqihar Medical University, Qiqihar, China. FAU - Cui, Hongsheng AU - Cui H AD - Department of Radiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China. FAU - Meng, Xin AU - Meng X AD - Department of Radiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China. FAU - Si, Yu AU - Si Y AD - Department of Psychiatry, Qiqihar Medical University, Qiqihar, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20211230 PL - United States TA - Brain Behav JT - Brain and behavior JID - 101570837 SB - IM MH - Brain/diagnostic imaging MH - Brain Mapping MH - *Depression/diagnostic imaging MH - Humans MH - *Magnetic Resonance Imaging/methods MH - Prefrontal Cortex/diagnostic imaging PMC - PMC8865143 OTO - NOTNLM OT - *actor/recipient role OT - *attribution OT - *default mode network OT - *depression OT - *negative self-focused thought COIS- The authors report no conflict of interest. EDAT- 2022/01/01 06:00 MHDA- 2022/04/19 06:00 PMCR- 2021/12/30 CRDT- 2021/12/31 06:21 PHST- 2021/11/16 00:00 [revised] PHST- 2021/02/09 00:00 [received] PHST- 2021/12/14 00:00 [accepted] PHST- 2022/01/01 06:00 [pubmed] PHST- 2022/04/19 06:00 [medline] PHST- 2021/12/31 06:21 [entrez] PHST- 2021/12/30 00:00 [pmc-release] AID - BRB32477 [pii] AID - 10.1002/brb3.2477 [doi] PST - ppublish SO - Brain Behav. 2022 Feb;12(2):e2477. doi: 10.1002/brb3.2477. Epub 2021 Dec 30.