PMID- 34971732
OWN - NLM
STAT- MEDLINE
DCOM- 20220428
LR  - 20220716
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 90
DP  - 2022 Mar-Apr
TI  - Impacts of a perinatal exposure to manganese coupled with maternal stress in 
      rats: Maternal somatic measures and the postnatal growth and development of rat 
      offspring.
PG  - 107061
LID - S0892-0362(21)00115-X [pii]
LID - 10.1016/j.ntt.2021.107061 [doi]
AB  - Psychological stress experienced by the mother during pregnancy has been 
      associated with emotional and cognitive disorders in children such as depression 
      and anxiety. Socioeconomically disadvantaged populations are vulnerable to 
      adverse life experiences and can also be disproportionally exposed to 
      environmental contaminants. To better understand the neurodevelopmental impacts 
      of an environmental toxicant coupled with elevated psychological stress, we 
      exposed pregnant rats to a series of perinatal stressors. Manganese (Mn), a 
      neurotoxicant at excessive concentrations was delivered through drinking water 
      (0, 2, or 4 mg/mL) from gestational day (GD) 7 to postnatal day (PND) 22. A 
      variable stress paradigm was applied to half of the animals from GD13 to PND9. 
      Measurements of somatic development and behavior were examined in the offspring 
      at different developmental stages. No evidence of overt maternal toxicity was 
      observed although the 4 mg/mL Mn-exposed dams gained less body weight during 
      gestation compared to the other dams. Stress also reduced gestational maternal 
      weight gain. Daily fluid consumption normalized for body weight was decreased in 
      the Mn-exposed dams in a dose-dependent manner but was not altered by the stress 
      paradigm. Maternal stress and/or Mn exposure did not affect litter size or 
      viability, but pup weight was significantly reduced in the 4 mg/mL Mn-exposed 
      groups on PNDs 9 through 34 when compared to the other offspring groups. The 
      efficacy of the manipulations to increase maternal stress levels was determined 
      using serum corticosterone as a biomarker. The baseline concentration was 
      established prior to treatment (GD7) and levels were low and similar in all 
      treatment groups. Corticosterone levels were elevated in the perinatal-stress 
      groups compared to the no-stress groups, regardless of Mn exposure, on subsequent 
      time points (GD16, PND9), but were only significantly different on GD16. An 
      analysis of tissue concentrations revealed Mn was elevated similarly in the brain 
      and blood of offspring at PND2 and at PND22 in a significant dose-dependent 
      pattern. Dams also showed a dose-dependent increase in Mn concentrations in the 
      brain and blood; the addition of stress increased the Mn concentrations in the 
      maternal blood but not the brain. Perinatal stress did not alter the effects of 
      Mn on the maternal or offspring somatic endpoints described here.
CI  - Published by Elsevier Inc.
FAU - Beasley, Tracey E
AU  - Beasley TE
AD  - Public Health & Integrated Toxicology Division, Center for Public Health and 
      Environmental Assessment, United States of America. Electronic address: 
      beasley.tracey@epa.gov.
FAU - McDaniel, Katherine L
AU  - McDaniel KL
AD  - Public Health & Integrated Toxicology Division, Center for Public Health and 
      Environmental Assessment, United States of America.
FAU - Oshiro, Wendy M
AU  - Oshiro WM
AD  - Public Health & Integrated Toxicology Division, Center for Public Health and 
      Environmental Assessment, United States of America.
FAU - Moser, Virginia C
AU  - Moser VC
AD  - Office of Research and Development, U.S. Environmental Protection Agency, 
      Research Triangle Park, NC 27711, United States of America.
FAU - MacMillan, Denise K
AU  - MacMillan DK
AD  - Chemical Characterization & Exposure Division, Center for Computational 
      Toxicology and Exposure, United States of America.
FAU - Herr, David W
AU  - Herr DW
AD  - Public Health & Integrated Toxicology Division, Center for Public Health and 
      Environmental Assessment, United States of America.
LA  - eng
GR  - EPA999999/ImEPA/Intramural EPA/United States
PT  - Journal Article
DEP - 20211228
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 42Z2K6ZL8P (Manganese)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Body Weight
MH  - Corticosterone/pharmacology
MH  - Female
MH  - Growth and Development
MH  - Humans
MH  - *Manganese/toxicity
MH  - Maternal Exposure/adverse effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced
MH  - Rats
PMC - PMC9128072
MID - NIHMS1773225
OTO - NOTNLM
OT  - Developmental neurotoxicity
OT  - Drinking water
OT  - Manganese
OT  - Perinatal stress
EDAT- 2022/01/01 06:00
MHDA- 2022/04/29 06:00
PMCR- 2022/05/24
CRDT- 2021/12/31 20:10
PHST- 2021/09/22 00:00 [received]
PHST- 2021/12/13 00:00 [revised]
PHST- 2021/12/23 00:00 [accepted]
PHST- 2022/01/01 06:00 [pubmed]
PHST- 2022/04/29 06:00 [medline]
PHST- 2021/12/31 20:10 [entrez]
PHST- 2022/05/24 00:00 [pmc-release]
AID - S0892-0362(21)00115-X [pii]
AID - 10.1016/j.ntt.2021.107061 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2022 Mar-Apr;90:107061. doi: 10.1016/j.ntt.2021.107061. 
      Epub 2021 Dec 28.