PMID- 34972259
OWN - NLM
STAT- MEDLINE
DCOM- 20220707
LR  - 20230222
IS  - 1360-0443 (Electronic)
IS  - 0965-2140 (Linking)
VI  - 117
IP  - 8
DP  - 2022 Aug
TI  - The efficacy and tolerability of pharmacologically active interventions for 
      alcohol-induced hangover symptomatology: a systematic review of the evidence from 
      randomised placebo-controlled trials.
PG  - 2157-2167
LID - 10.1111/add.15786 [doi]
AB  - AIMS: To compare quantitatively the efficacy and tolerability of 
      pharmacologically active interventions in the treatment and prevention of 
      alcohol-induced hangover. METHODS: Systematic review of placebo-controlled 
      randomised trials in healthy adults that evaluated any pharmacologically active 
      intervention in the treatment or prevention of hangover. We searched Medline, 
      Embase, PsycINFO and CENTRAL from database inception until 1 August 2021. The 
      primary efficacy outcome was any continuous measure of overall hangover symptoms 
      and the primary tolerability outcome the number of people dropping out because of 
      adverse events (AEs). Quality was assessed using the Grading of Recommendations 
      Assessment Development and Evaluation (GRADE) framework. RESULTS: A total of 21 
      studies were included reporting on 386 participants. No two studies reported on 
      the same intervention; as such, meta-analysis could not be undertaken. 
      Methodological concerns and imprecision resulted in all studied efficacy outcomes 
      being rated as very low quality. When compared with placebo, individual studies 
      reported a statistically significant reduction in the mean percentage overall 
      hangover symptom score for clove extract (42.5% vs 19.0%, P < 0.001), tolfenamic 
      acid (84.0% vs 50.0%, P < 0.001), pyritinol (34.1% vs 16.2%, P < 0.01), Hovenia 
      dulcis fruit extract (P = 0.029), L-cysteine (P = 0.043), red ginseng (21.1% vs 
      14.0%, P < 0.05) and Korean pear juice (41.5% vs 33.3%, P < 0.05). All studied 
      tolerability outcomes were of low or very low quality with no studies reporting 
      any drop-outs because of AEs. CONCLUSIONS: Only very low quality evidence of 
      efficacy is available to recommend any pharmacologically active intervention for 
      the treatment or prevention of alcohol-induced hangover. Of the limited 
      interventions studied, all had favourable tolerability profiles and very low 
      quality evidence suggests clove extract, tolfenamic acid and pyritinol may most 
      warrant further study.
CI  - (c) 2021 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of 
      Society for the Study of Addiction.
FAU - Roberts, Emmert
AU  - Roberts E
AUID- ORCID: 0000-0002-4152-5570
AD  - National Addiction Centre, Institute of Psychiatry, Psychology and Neuroscience, 
      King's College London, London, United Kingdom.
AD  - Department of Psychological Medicine, Institute of Psychiatry, Psychology and 
      Neuroscience, King's College London, London, United Kingdom.
AD  - South London and the Maudsley NHS Foundation Trust, London, United Kingdom.
FAU - Smith, Rachel
AU  - Smith R
AD  - South London and the Maudsley NHS Foundation Trust, London, United Kingdom.
FAU - Hotopf, Matthew
AU  - Hotopf M
AD  - Department of Psychological Medicine, Institute of Psychiatry, Psychology and 
      Neuroscience, King's College London, London, United Kingdom.
AD  - South London and the Maudsley NHS Foundation Trust, London, United Kingdom.
FAU - Drummond, Colin
AU  - Drummond C
AD  - National Addiction Centre, Institute of Psychiatry, Psychology and Neuroscience, 
      King's College London, London, United Kingdom.
AD  - South London and the Maudsley NHS Foundation Trust, London, United Kingdom.
LA  - eng
GR  - G0701681/MRC_/Medical Research Council/United Kingdom
GR  - G0701818/MRC_/Medical Research Council/United Kingdom
GR  - MR/N00616X/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20220124
PL  - England
TA  - Addiction
JT  - Addiction (Abingdon, England)
JID - 9304118
RN  - AK5Q5FZH2R (Pyrithioxin)
SB  - IM
MH  - Adult
MH  - *Alcoholic Intoxication
MH  - Humans
MH  - *Pyrithioxin
MH  - Randomized Controlled Trials as Topic
OTO - NOTNLM
OT  - alcohol
OT  - hangover
OT  - pharmacology
OT  - prevention
OT  - systematic review
OT  - treatment
EDAT- 2022/01/01 06:00
MHDA- 2022/07/08 06:00
CRDT- 2021/12/31 20:35
PHST- 2021/10/06 00:00 [received]
PHST- 2021/12/13 00:00 [accepted]
PHST- 2022/01/01 06:00 [pubmed]
PHST- 2022/07/08 06:00 [medline]
PHST- 2021/12/31 20:35 [entrez]
AID - 10.1111/add.15786 [doi]
PST - ppublish
SO  - Addiction. 2022 Aug;117(8):2157-2167. doi: 10.1111/add.15786. Epub 2022 Jan 24.