PMID- 34972693
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20231101
IS  - 1470-7926 (Electronic)
IS  - 1351-0711 (Print)
IS  - 1351-0711 (Linking)
VI  - 79
IP  - 6
DP  - 2022 Jun
TI  - Markers of kidney tubular and interstitial injury and function among sugarcane 
      workers with cross-harvest serum creatinine elevation.
PG  - 396-402
LID - 10.1136/oemed-2021-107989 [doi]
AB  - OBJECTIVES: Serum creatinine (SCr) is a routine marker of kidney injury but also 
      increases with dehydration and muscular work. This study was to elucidate whether 
      increase in SCr is associated with more specific markers of kidney tubular and 
      interstitial injury and function, during prolonged heat stress among workers at 
      high risk of chronic kidney disease of non-traditional origin (CKDnt). METHODS: 
      Urine monocyte chemoattractant protein-1 (MCP-1), kidney injury molecule-1 
      (KIM-1), calbindin, glutathione S-transferase-pi (GST-pi), clusterin, interleukin 
      18 and albumin, fractional excretion of potassium (FEK), blood haemoglobin, serum 
      potassium, ferritin and erythropoietin were measured before and after harvest in 
      a sample of 30 workers with a >/=0.3 mg/dL SCr increase across harvest (cases), and 
      53 workers with stable SCr (controls). RESULTS: Urine MCP-1 (p for differential 
      cross-harvest trend <0.001), KIM-1 (p=0.002), calbindin (p=0.02), GST-pi (p=0.04), 
      albumin (p=0.001) and FEK (p<0.001) increased in cases, whereas blood haemoglobin 
      (p<0.001) and serum erythropoietin (p<0.001) decreased. CONCLUSION: Several 
      markers of tubular and interstitial injury and function changed as SCr increased 
      across a harvest season, supporting the use of SCr as an indicator of kidney 
      injury in physically active workers regularly exposed to heat stress. Repeated 
      injury similar to that described here, and continued work under strenuous and hot 
      conditions with similarly elevated injury markers is likely to worsen and 
      possibly initiate CKDnt.
CI  - (c) Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published 
      by BMJ.
FAU - Hansson, Erik
AU  - Hansson E
AUID- ORCID: 0000-0002-9779-6820
AD  - La Isla Network, Washington, DC, USA erik.hansson@amm.gu.se.
AD  - School of Public Health and Community Medicine, Institute of Medicine, University 
      of Gothenburg Sahlgrenska Academy, Gothenburg, Sweden.
FAU - Wegman, David H
AU  - Wegman DH
AUID- ORCID: 0000-0001-6393-5020
AD  - La Isla Network, Washington, DC, USA.
AD  - University of Massachusetts Lowell, Lowell, Massachusetts, USA.
FAU - Wesseling, Catharina
AU  - Wesseling C
AD  - La Isla Network, Washington, DC, USA.
AD  - Unit of Occupational Medicine, Institute of Environmental Medicine, Karolinska 
      Institutet, Stockholm, Sweden.
FAU - Glaser, Jason
AU  - Glaser J
AD  - La Isla Network, Washington, DC, USA.
FAU - Schlader, Zachary J
AU  - Schlader ZJ
AD  - Department of Kinesiology, Indiana University Bloomington School of Public 
      Health, Bloomington, Indiana, USA.
FAU - Wijkstrom, Julia
AU  - Wijkstrom J
AD  - Division of Renal Medicine, Department of Clinical Science, Intervention and 
      Technology, Karolinska Institutet, Stockholm, Sweden.
FAU - Jakobsson, Kristina
AU  - Jakobsson K
AD  - La Isla Network, Washington, DC, USA.
AD  - School of Public Health and Community Medicine, Institute of Medicine, University 
      of Gothenburg Sahlgrenska Academy, Gothenburg, Sweden.
AD  - Occupational and Environmental Medicine, Sahlgrenska University Hospital, 
      Gothenburg, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211231
PL  - England
TA  - Occup Environ Med
JT  - Occupational and environmental medicine
JID - 9422759
RN  - 0 (Albumins)
RN  - 0 (Biomarkers)
RN  - 0 (Calbindins)
RN  - 11096-26-7 (Erythropoietin)
RN  - AYI8EX34EU (Creatinine)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - *Acute Kidney Injury
MH  - Albumins
MH  - Biomarkers
MH  - Calbindins
MH  - Creatinine
MH  - *Erythropoietin
MH  - Female
MH  - *Heat Stress Disorders/complications
MH  - Humans
MH  - Kidney
MH  - Male
MH  - Potassium
MH  - *Renal Insufficiency, Chronic/etiology
MH  - *Saccharum
PMC - PMC9120403
OTO - NOTNLM
OT  - climate
OT  - kidney diseases
OT  - occupational health
OT  - physical exertion
COIS- Competing interests: None declared.
EDAT- 2022/01/02 06:00
MHDA- 2022/05/18 06:00
PMCR- 2022/05/20
CRDT- 2022/01/01 05:18
PHST- 2021/09/03 00:00 [received]
PHST- 2021/12/08 00:00 [accepted]
PHST- 2022/01/02 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/01/01 05:18 [entrez]
PHST- 2022/05/20 00:00 [pmc-release]
AID - oemed-2021-107989 [pii]
AID - 10.1136/oemed-2021-107989 [doi]
PST - ppublish
SO  - Occup Environ Med. 2022 Jun;79(6):396-402. doi: 10.1136/oemed-2021-107989. Epub 
      2021 Dec 31.