PMID- 34973317
OWN - NLM
STAT- MEDLINE
DCOM- 20220216
LR  - 20220216
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 814
DP  - 2022 Mar 25
TI  - Effects of exposure to single and multiple parabens on asthma development in an 
      experimental mouse model and a prospective cohort study.
PG  - 152676
LID - S0048-9697(21)07754-8 [pii]
LID - 10.1016/j.scitotenv.2021.152676 [doi]
AB  - Parabens are widely used preservatives present in consumer products like 
      cosmetics and food. Although several epidemiological studies suggest that 
      early-life exposure to parabens might alter the immune response and allergy risk 
      in childhood, the evidence with respect to asthma is not clear. Therefore, we 
      investigated the effect of paraben exposure on asthma development in mice and 
      humans. Using a murine asthma model the experimental data show both, an 
      asthma-reducing effect after direct exposure of adult mice to n-butyl paraben 
      (nBuP) as well as an asthma-promoting effect after maternal exposure to ethyl 
      paraben (EtP) in the female offspring. Interestingly, exposure of mice to a 
      mixture of EtP and nBuP starting prenatally until the end of asthma induction in 
      the adult offspring was without effect on allergic airway inflammation. In 
      addition, parabens were determined within the German prospective mother-child 
      cohort LINA and their single and mixture effect on asthma development in children 
      within the first 10 years of life was estimated by logistic and Bayesian kernel 
      machine regression (BKMR). Both approaches revealed no adverse effects of 
      parabens on children's asthma development, neither when stratified for being at 
      risk due to a positive family history of atopy nor when analysed separately for 
      sex specificity. Therefore, we conclude that although single parabens might 
      differentially impact asthma development, an adverse effect could not be seen in 
      a multiple paraben exposure setting. Consequently, not only the time point of 
      exposure but also multiple exposure scenarios to parabens should be considered in 
      the evaluation of individuals' specific disease risk.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Junge, Kristin M
AU  - Junge KM
AD  - Helmholtz Centre for Environmental Research - UFZ, Department of Environmental 
      Immunology, Leipzig, Germany; Institute of Agriculture and Nutritional Sciences, 
      Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
FAU - Buchenauer, Lisa
AU  - Buchenauer L
AD  - Helmholtz Centre for Environmental Research - UFZ, Department of Environmental 
      Immunology, Leipzig, Germany; Department of Dermatology, Venerology and 
      Allergology, Leipzig University Medical Center, University of Leipzig, Leipzig, 
      Germany.
FAU - Strunz, Sandra
AU  - Strunz S
AD  - Helmholtz Centre for Environmental Research - UFZ, Department of Environmental 
      Immunology, Leipzig, Germany; Department of Dermatology, Venerology and 
      Allergology, Leipzig University Medical Center, University of Leipzig, Leipzig, 
      Germany.
FAU - Seiwert, Bettina
AU  - Seiwert B
AD  - Helmholtz Centre for Environmental Research - UFZ, Department for Analytical 
      Chemistry, Leipzig, Germany.
FAU - Thurmann, Loreen
AU  - Thurmann L
AD  - Berlin Institute of Health at Charite - Universitatsmedizin Berlin, Molecular 
      Epidemiology, Berlin, Germany.
FAU - Rolle-Kampczyk, Ulrike E
AU  - Rolle-Kampczyk UE
AD  - Helmholtz Centre for Environmental Research - UFZ, Department of Molecular 
      Systems Biology, Leipzig, Germany.
FAU - Roder, Stefan
AU  - Roder S
AD  - Helmholtz Centre for Environmental Research - UFZ, Department of Environmental 
      Immunology, Leipzig, Germany.
FAU - Borte, Michael
AU  - Borte M
AD  - Children's Hospital, Municipal Hospital "St. Georg", Leipzig, Germany.
FAU - Kiess, Wieland
AU  - Kiess W
AD  - University of Leipzig, Hospital for Children and Adolescents - Centre for 
      Pediatric Research, Leipzig, Germany; University of Leipzig, LIFE - Leipzig 
      Research Centre for Civilization Diseases, Leipzig, Germany.
FAU - von Bergen, Martin
AU  - von Bergen M
AD  - Helmholtz Centre for Environmental Research - UFZ, Department of Molecular 
      Systems Biology, Leipzig, Germany; University of Leipzig, Faculty of Life 
      Sciences, Institute of Biochemistry, Leipzig, Germany.
FAU - Simon, Jan C
AU  - Simon JC
AD  - Department of Dermatology, Venerology and Allergology, Leipzig University Medical 
      Center, University of Leipzig, Leipzig, Germany.
FAU - Zenclussen, Ana C
AU  - Zenclussen AC
AD  - Helmholtz Centre for Environmental Research - UFZ, Department of Environmental 
      Immunology, Leipzig, Germany.
FAU - Schoneberg, Torsten
AU  - Schoneberg T
AD  - University of Leipzig, Medical Faculty, Rudolf Schonheimer Institute of 
      Biochemistry, Leipzig, Germany.
FAU - Stangl, Gabriele I
AU  - Stangl GI
AD  - Institute of Agriculture and Nutritional Sciences, Martin Luther University 
      Halle-Wittenberg, Halle (Saale), Germany.
FAU - Herberth, Gunda
AU  - Herberth G
AD  - Helmholtz Centre for Environmental Research - UFZ, Department of Environmental 
      Immunology, Leipzig, Germany.
FAU - Lehmann, Irina
AU  - Lehmann I
AD  - Berlin Institute of Health at Charite - Universitatsmedizin Berlin, Molecular 
      Epidemiology, Berlin, Germany; German Center for Lung Research (DZL), associated 
      partner, Berlin, Germany.
FAU - Reemtsma, Thorsten
AU  - Reemtsma T
AD  - Helmholtz Centre for Environmental Research - UFZ, Department for Analytical 
      Chemistry, Leipzig, Germany.
FAU - Polte, Tobias
AU  - Polte T
AD  - Helmholtz Centre for Environmental Research - UFZ, Department of Environmental 
      Immunology, Leipzig, Germany; Department of Dermatology, Venerology and 
      Allergology, Leipzig University Medical Center, University of Leipzig, Leipzig, 
      Germany. Electronic address: tobias.polte@ufz.de.
LA  - eng
PT  - Journal Article
DEP - 20211230
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Parabens)
SB  - IM
MH  - Animals
MH  - *Asthma/chemically induced/epidemiology
MH  - Bayes Theorem
MH  - Cohort Studies
MH  - Female
MH  - Mice
MH  - *Parabens/toxicity
MH  - Prospective Studies
OTO - NOTNLM
OT  - Asthma
OT  - BKMR
OT  - LINA cohort
OT  - Murine model
OT  - Paraben exposure
OT  - Single and mixture effect
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/01/02 06:00
MHDA- 2022/02/17 06:00
CRDT- 2022/01/01 20:09
PHST- 2021/11/12 00:00 [received]
PHST- 2021/12/15 00:00 [revised]
PHST- 2021/12/21 00:00 [accepted]
PHST- 2022/01/02 06:00 [pubmed]
PHST- 2022/02/17 06:00 [medline]
PHST- 2022/01/01 20:09 [entrez]
AID - S0048-9697(21)07754-8 [pii]
AID - 10.1016/j.scitotenv.2021.152676 [doi]
PST - ppublish
SO  - Sci Total Environ. 2022 Mar 25;814:152676. doi: 10.1016/j.scitotenv.2021.152676. 
      Epub 2021 Dec 30.