PMID- 34973942
OWN - NLM
STAT- MEDLINE
DCOM- 20220401
LR  - 20220401
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 207
DP  - 2022 May 1
TI  - Single and mixed effects of prenatal exposure to multiple bisphenols on 
      hemoglobin levels and the risk of anemia in pregnant women.
PG  - 112625
LID - S0013-9351(21)01926-5 [pii]
LID - 10.1016/j.envres.2021.112625 [doi]
AB  - INTRODUCTION: Bisphenols have endocrine-disrupting effects, which may disrupt 
      hemoglobin (Hb) homeostasis and lead to anemia. However, the effects of 
      bisphenols on anemia remain unknown. Therefore, we assessed the effects of 
      single- and multiple-exposure to bisphenols on Hb levels and anemia of pregnant 
      women. METHODS: The study involved 2035 pregnant women from Guangxi Zhuang Birth 
      Cohort in China. Generalized linear regression, principal component analysis 
      (PCA), quantile g-computation (Qgcomp), and Bayesian kernel machine regression 
      (BKMR) were performed to examine the effects of serum bisphenols on Hb levels and 
      the risk of anemia. RESULTS: After adjustment, elevated bisphenol A (BPA) levels 
      were correlated with decreased Hb concentrations (beta = -0.51; 95%CI: -0.92, -0.10) 
      in the first trimester, and these correlations were more sensitive in mothers of 
      males. Compared with the low-exposure group, bisphenol B (BPB) levels in the 
      high-exposure group led to a 1.52 g/L (95%CI: -3.01, -0.03) decrease in Hb levels 
      in the second trimester; tetrabromobisphenol A (TBBPA) levels in the 
      high-exposure group led to a higher the risk of anemia in the third trimester 
      (OR = 1.46; 95%CI: 1.07, 1.99); bisphenol F (BPF) in the high-exposure group led 
      to lower Hb levels (beta = -2.42; 95%CI:-4.69, -0.14) in mothers of male fetuses in 
      the third trimester. Qgcomp showed that elevated levels of bisphenol mixture was 
      correlated with (beta = -1.42; 95%CI: -2.61, -0.24) decrease in Hb levels in the 
      second trimester. PCA revealed a negative association between PC2 and Hb levels 
      in the first trimester (beta = -0.89; 95%CI: -1.61, -0.17). Similarly, a negative 
      relationship was observed between PC1 and Hb levels in the third trimester among 
      mothers with male fetuses (beta = -1.00; 95%CI: -1.94, -0.06). CONCLUSIONS: Prenatal 
      exposure to single and mixed bisphenols may decrease Hb levels and increase the 
      risk of anemia during pregnancy, the associations may be greater in mothers with 
      male fetuses than those with female fetuses.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Liang, Jun
AU  - Liang J
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning, 530021, Guangxi, China.
FAU - Yang, Chunxiu
AU  - Yang C
AD  - The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 
      530021, China.
FAU - Liu, Tao
AU  - Liu T
AD  - Huaihua Center for Disease Control and Prevention, Huaihua, 418000, Hunan, China.
FAU - Tang, Peng
AU  - Tang P
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning, 530021, Guangxi, China.
FAU - Huang, Huishen
AU  - Huang H
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning, 530021, Guangxi, China.
FAU - Wei, Huanni
AU  - Wei H
AD  - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical 
      University, Nanning, 530021, Guangxi, China.
FAU - Liao, Qian
AU  - Liao Q
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning, 530021, Guangxi, China.
FAU - Long, Jinghua
AU  - Long J
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning, 530021, Guangxi, China.
FAU - Zeng, Xiaoyun
AU  - Zeng X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning, 530021, Guangxi, China.
FAU - Liu, Shun
AU  - Liu S
AD  - Department of Child and Adolescent Health & Maternal and Child Health, School of 
      Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China.
FAU - Huang, Dongping
AU  - Huang D
AD  - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical 
      University, Nanning, 530021, Guangxi, China.
FAU - Qiu, Xiaoqiang
AU  - Qiu X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning, 530021, Guangxi, China. Electronic address: 
      xqqiu9999@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211230
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Hemoglobins)
RN  - 0 (Phenols)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - *Anemia/chemically induced/epidemiology
MH  - Bayes Theorem
MH  - Benzhydryl Compounds/toxicity
MH  - China/epidemiology
MH  - Female
MH  - Hemoglobins
MH  - Humans
MH  - Male
MH  - Phenols
MH  - Pregnancy
MH  - Pregnant Women
MH  - *Prenatal Exposure Delayed Effects
OTO - NOTNLM
OT  - Anemia
OT  - Bisphenols
OT  - Hemoglobin
OT  - Pregnant women
OT  - Serum
EDAT- 2022/01/03 06:00
MHDA- 2022/04/02 06:00
CRDT- 2022/01/02 20:19
PHST- 2021/10/14 00:00 [received]
PHST- 2021/12/21 00:00 [revised]
PHST- 2021/12/23 00:00 [accepted]
PHST- 2022/01/03 06:00 [pubmed]
PHST- 2022/04/02 06:00 [medline]
PHST- 2022/01/02 20:19 [entrez]
AID - S0013-9351(21)01926-5 [pii]
AID - 10.1016/j.envres.2021.112625 [doi]
PST - ppublish
SO  - Environ Res. 2022 May 1;207:112625. doi: 10.1016/j.envres.2021.112625. Epub 2021 
      Dec 30.