PMID- 34975301 OWN - NLM STAT- MEDLINE DCOM- 20220323 LR - 20220323 IS - 1449-1907 (Electronic) IS - 1449-1907 (Linking) VI - 19 IP - 1 DP - 2022 TI - Association of plasma fatty acid-binding protein 3 with estimated glomerular filtration rate in patients with type 2 diabetes mellitus. PG - 82-88 LID - 10.7150/ijms.66876 [doi] AB - Background: Fatty acid-binding protein 3 (FABP3) located in renal mesangial and distal tubular cells, and had been shown to be a sensitive marker of renal injury, potentially be a mediator in pathogenesis of chronic kidney disease (CKD). Our previous study revealed that plasma FABP1 and FABP2 were independently associated with CKD, however, little is known about the relationship between plasma FABP3 level and CKD. The aim of this study was therefore to evaluate the plasma levels of FABP3 at different stages of estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 334 subjects with T2DM who enrolled in a disease management program were included in this study and stratified according to eGFR. Plasma FABP3 concentrations were measured by an enzyme-linked immunosorbent assay. Results: FABP3 levels increased in parallel with the eGFR level. Increasing concentrations of FABP3 were independently and significantly associated with eGFR stage G2-G4. Age- and sex-adjusted FABP3 levels were positively associated with uric acid, urinary albumin-to-creatinine ratio, FABP1, FABP2, and fatty liver index, but negatively associated with eGFR and hemoglobin. Conclusion: Our results indicate that circulating FABP3 in patients with T2DM is associated with eGFR, which suggests that increased plasma FABP3 may be involved in the pathogenesis of CKD. CI - (c) The author(s). FAU - Yu, Teng-Hung AU - Yu TH AD - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445 Taiwan. AD - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. FAU - Hsuan, Chin-Feng AU - Hsuan CF AD - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445 Taiwan. AD - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. AD - Division of Cardiology, Department of Internal Medicine, E-Da Dachang Hospital, Kaohsiung, 80794 Taiwan. FAU - Wu, Cheng-Ching AU - Wu CC AD - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445 Taiwan. AD - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. FAU - Hung, Wei-Chin AU - Hung WC AD - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445 Taiwan. AD - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. FAU - Lee, Thung-Lip AU - Lee TL AD - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445 Taiwan. AD - School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. FAU - Tsai, I-Ting AU - Tsai IT AD - Department of Emergency, E-Da Hospital, Kaohsiung 82445 Taiwan. AD - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. FAU - Wei, Ching-Ting AU - Wei CT AD - Division of General Surgery, Department of Surgery, E-Da Hospital, Kaohsiung 82445 Taiwan. AD - School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. AD - Department of Biomedical Engineering, I-Shou University, Kaohsiung, 82445 Taiwan. AD - Department of Electrical Engineering, I-Shou University, Kaohsiung, 82445 Taiwan. FAU - Houng, Jer-Yiing AU - Houng JY AD - Department of Nutrition, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. AD - Department of Chemical Engineering, I-Shou University, Kaohsiung, 82445 Taiwan. FAU - Chung, Fu-Mei AU - Chung FM AD - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445 Taiwan. FAU - Lee, Yau-Jiunn AU - Lee YJ AD - Lee's Endocrinologic Clinic, Pingtung 90000 Taiwan. FAU - Lu, Yung-Chuan AU - Lu YC AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445 Taiwan. AD - School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. LA - eng PT - Journal Article DEP - 20220101 PL - Australia TA - Int J Med Sci JT - International journal of medical sciences JID - 101213954 RN - 0 (Biomarkers) RN - 0 (FABP3 protein, human) RN - 0 (Fatty Acid Binding Protein 3) SB - IM MH - Biomarkers/blood MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/*blood/physiopathology MH - Diabetic Nephropathies/*diagnosis MH - Fatty Acid Binding Protein 3/*blood MH - Female MH - *Glomerular Filtration Rate MH - Humans MH - Male MH - Middle Aged MH - Renal Insufficiency, Chronic/*diagnosis PMC - PMC8692122 OTO - NOTNLM OT - Type 2 diabetes mellitus OT - estimated glomerular filtration rate OT - fatty acid-binding protein 3 COIS- Competing Interests: The authors have declared that no competing interest exists. EDAT- 2022/01/04 06:00 MHDA- 2022/03/24 06:00 PMCR- 2022/01/01 CRDT- 2022/01/03 05:34 PHST- 2021/09/07 00:00 [received] PHST- 2021/11/10 00:00 [accepted] PHST- 2022/01/03 05:34 [entrez] PHST- 2022/01/04 06:00 [pubmed] PHST- 2022/03/24 06:00 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - ijmsv19p0082 [pii] AID - 10.7150/ijms.66876 [doi] PST - epublish SO - Int J Med Sci. 2022 Jan 1;19(1):82-88. doi: 10.7150/ijms.66876. eCollection 2022.