PMID- 34975372
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220104
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 15
DP  - 2021
TI  - Aberrant Brain Spontaneous Activity and Synchronization in Type 2 Diabetes 
      Mellitus Subjects Without Mild Cognitive Impairment.
PG  - 749730
LID - 10.3389/fnins.2021.749730 [doi]
LID - 749730
AB  - Objective: We aimed to explore whether the percent amplitude of fluctuation 
      (PerAF) measurement could provide supplementary information for amplitude of 
      low-frequency fluctuation (ALFF) about spontaneous activity alteration in type 2 
      diabetes mellitus (T2DM) subjects without mild cognitive impairment (MCI). Then 
      we further evaluated the synchronization through the method of functional 
      connectivity (FC) to better demonstrate brain changes in a more comprehensive 
      manner in T2DM. Methods: Thirty T2DM subjects without MCI and thirty well-matched 
      healthy subjects were recruited in this study. Subjects' clinical data, 
      neuropsychological test results, and resting-state functional magnetic resonance 
      imaging (rs-fMRI) data were acquired. Voxel-based group difference comparisons 
      between PerAF and ALFF were conducted. Then, seed-based FC between the recognized 
      brain regions based on PerAF and ALFF and the rest of the whole brain was 
      performed. Results: Compared with healthy group, T2DM group had significantly 
      decreased PerAF in the bilateral middle occipital gyrus and the right calcarine, 
      increased ALFF in the right orbital inferior frontal gyrus and decreased ALFF in 
      the right calcarine. Seed-based FC analysis showed that the right middle 
      occipital gyrus of T2DM subjects exhibited significantly decreased FC with the 
      right caudate nucleus and right putamen. According to the partial correlation 
      analyses, hemoglobin A1c (HbA1c) and immediate memory scores on the auditory 
      verbal learning test (AVLT) were negatively correlated in the T2DM group. 
      However, we found that total cholesterol was positively correlated with symbol 
      digit test (SDT) scores. Conclusion: PerAF and ALFF may have different 
      sensitivities in detecting the abnormal spontaneous brain activity in T2DM 
      subjects. We suggest PerAF values may add supplementary information and indicate 
      additional potential neuronal spontaneous activity in T2DM subjects without MCI, 
      which may provide new insights into the neuroimaging mechanisms underlying early 
      diabetes-associated cognitive decline.
CI  - Copyright (c) 2021 Li, Li, Feng, Ma, Tan, Chen, Qin, Huang, Liang and Qiu.
FAU - Li, Yifan
AU  - Li Y
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Li, Mingrui
AU  - Li M
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Feng, Yue
AU  - Feng Y
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Ma, Xiaomeng
AU  - Ma X
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Tan, Xin
AU  - Tan X
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Chen, Yuna
AU  - Chen Y
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Qin, Chunhong
AU  - Qin C
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Huang, Haoming
AU  - Huang H
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Liang, Yi
AU  - Liang Y
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Qiu, Shijun
AU  - Qiu S
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20211216
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC8716545
OTO - NOTNLM
OT  - cognitive function
OT  - functional connectivity
OT  - percent amplitude of fluctuation
OT  - resting-state
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/01/04 06:00
MHDA- 2022/01/04 06:01
PMCR- 2021/01/01
CRDT- 2022/01/03 05:35
PHST- 2021/07/29 00:00 [received]
PHST- 2021/11/19 00:00 [accepted]
PHST- 2022/01/03 05:35 [entrez]
PHST- 2022/01/04 06:00 [pubmed]
PHST- 2022/01/04 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2021.749730 [doi]
PST - epublish
SO  - Front Neurosci. 2021 Dec 16;15:749730. doi: 10.3389/fnins.2021.749730. 
      eCollection 2021.