PMID- 34975524
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220104
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 12
DP  - 2021
TI  - Impact of Dietary Restriction Regimens on Mitochondria, Heart, and Endothelial 
      Function: A Brief Overview.
PG  - 768383
LID - 10.3389/fphys.2021.768383 [doi]
LID - 768383
AB  - Caloric restriction (CR) and intermittent fasting (IF) are strategies aimed to 
      promote health beneficial effects by interfering with several mechanisms 
      responsible for cardiovascular diseases. Both dietary approaches decrease body 
      weight, insulin resistance, blood pressure, lipids, and inflammatory status. All 
      these favorable effects are the result of several metabolic adjustments, which 
      have been addressed in this review, i.e., the improvement of mitochondrial 
      biogenesis, the reduction of reactive oxygen species (ROS) production, and the 
      improvement of cardiac and vascular function. CR and IF are able to modulate 
      mitochondrial function via interference with dynamics (i.e., fusion and fission), 
      respiration, and related oxidative stress. In the cardiovascular system, both 
      dietary interventions are able to improve endothelium-dependent relaxation, 
      reduce cardiac hypertrophy, and activate antiapoptotic signaling cascades. 
      Further clinical studies are required to assess the long-term safety in the 
      clinical setting.
CI  - Copyright (c) 2021 Savencu, Linta, Farcas, Bina, Cretu, Malita, Muntean and Sturza.
FAU - Savencu, Cristina Elena
AU  - Savencu CE
AD  - Faculty of Dentistry, Department of Dental Prostheses Technology, Victor Babes 
      University of Medicine and Pharmacy, Timisoara, Romania.
FAU - Linta, Adina
AU  - Linta A
AD  - Faculty of Medicine, Department of Functional Sciences - Pathophysiology, Victor 
      Babes University of Medicine and Pharmacy, Timisoara, Romania.
AD  - Faculty of Medicine, Centre for Translational Research and Systems Medicine, 
      Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
FAU - Farcas, Gianina
AU  - Farcas G
AD  - Faculty of Medicine, Department of Functional Sciences - Pathophysiology, Victor 
      Babes University of Medicine and Pharmacy, Timisoara, Romania.
AD  - Faculty of Medicine, Centre for Translational Research and Systems Medicine, 
      Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
FAU - Bina, Anca Mihaela
AU  - Bina AM
AD  - Faculty of Medicine, Department of Functional Sciences - Pathophysiology, Victor 
      Babes University of Medicine and Pharmacy, Timisoara, Romania.
AD  - Faculty of Medicine, Centre for Translational Research and Systems Medicine, 
      Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
FAU - Cretu, Octavian Marius
AU  - Cretu OM
AD  - Faculty of Medicine, Department of Surgery - Surgical Semiotics I, Victor Babes 
      University of Medicine and Pharmacy, Timisoara, Romania.
AD  - Faculty of Medicine, Centre for Hepato-Biliary and Pancreatic Surgery, Victor 
      Babes University of Medicine and Pharmacy, Timisoara, Romania.
FAU - Malita, Daniel Claudiu
AU  - Malita DC
AD  - Faculty of Medicine, Department of Radiology and Medical Imagistics, Victor Babes 
      University of Medicine and Pharmacy, Timisoara, Romania.
FAU - Muntean, Danina Mirela
AU  - Muntean DM
AD  - Faculty of Medicine, Department of Functional Sciences - Pathophysiology, Victor 
      Babes University of Medicine and Pharmacy, Timisoara, Romania.
AD  - Faculty of Medicine, Centre for Translational Research and Systems Medicine, 
      Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
FAU - Sturza, Adrian
AU  - Sturza A
AD  - Faculty of Medicine, Department of Functional Sciences - Pathophysiology, Victor 
      Babes University of Medicine and Pharmacy, Timisoara, Romania.
AD  - Faculty of Medicine, Centre for Translational Research and Systems Medicine, 
      Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211216
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC8716834
OTO - NOTNLM
OT  - caloric restriction
OT  - cardiovascular disease
OT  - endothelial dysfunction
OT  - intermittent fasting
OT  - mitochondrial function
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/01/04 06:00
MHDA- 2022/01/04 06:01
PMCR- 2021/12/16
CRDT- 2022/01/03 05:36
PHST- 2021/08/31 00:00 [received]
PHST- 2021/11/17 00:00 [accepted]
PHST- 2022/01/03 05:36 [entrez]
PHST- 2022/01/04 06:00 [pubmed]
PHST- 2022/01/04 06:01 [medline]
PHST- 2021/12/16 00:00 [pmc-release]
AID - 10.3389/fphys.2021.768383 [doi]
PST - epublish
SO  - Front Physiol. 2021 Dec 16;12:768383. doi: 10.3389/fphys.2021.768383. eCollection 
      2021.