PMID- 34976208
OWN - NLM
STAT- MEDLINE
DCOM- 20220310
LR  - 20220801
IS  - 1838-7640 (Electronic)
IS  - 1838-7640 (Linking)
VI  - 12
IP  - 2
DP  - 2022
TI  - Dodging blood brain barrier with "nano" warriors: Novel strategy against ischemic 
      stroke.
PG  - 689-719
LID - 10.7150/thno.64806 [doi]
AB  - Ischemic stroke (IS) is one of the leading causes of death and disability 
      resulting in inevitable burden globally. Ischemic injury initiates cascade of 
      pathological events comprising energy dwindling, failure of ionic gradients, 
      failure of blood brain barrier (BBB), vasogenic edema, calcium over accumulation, 
      excitotoxicity, increased oxidative stress, mitochondrial dysfunction, 
      inflammation and eventually cell death. In spite of such complexity of the 
      disease, the only treatment approved by US Food and Drug Administration (FDA) is 
      tissue plasminogen activator (t-PA). This therapy overcome blood deficiency in 
      the brain along with side effects of reperfusion which are responsible for 
      considerable tissue injury. Therefore, there is urgent need of novel therapeutic 
      perspectives that can protect the integrity of BBB and salvageable brain tissue. 
      Advancement in nanomedicine is empowering new approaches that are potent to 
      improve the understanding and treatment of the IS. Herein, we focus nanomaterial 
      mediated drug delivery systems (DDSs) and their role to bypass and cross BBB 
      especially via intranasal drug delivery. The various nanocarriers used in DDSs 
      are also discussed. In a nut shell, the objective is to provide an overview of 
      use of nanomedicine in the diagnosis and treatment of IS to facilitate the 
      research from benchtop to bedside.
CI  - (c) The author(s).
FAU - Parvez, Suhel
AU  - Parvez S
AD  - Department of Toxicology, School of Chemical & Life Sciences, Jamia Hamdard, New 
      Delhi 110062, India.
FAU - Kaushik, Medha
AU  - Kaushik M
AD  - Department of Toxicology, School of Chemical & Life Sciences, Jamia Hamdard, New 
      Delhi 110062, India.
FAU - Ali, Mubashshir
AU  - Ali M
AD  - Department of Toxicology, School of Chemical & Life Sciences, Jamia Hamdard, New 
      Delhi 110062, India.
FAU - Alam, Mohammad Mumtaz
AU  - Alam MM
AD  - Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, 
      School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 
      110062, India.
FAU - Ali, Javed
AU  - Ali J
AD  - Department of Pharmaceutics, School of Pharmaceutical Education and Research, 
      Jamia Hamdard, New Delhi - 110062, India.
FAU - Tabassum, Heena
AU  - Tabassum H
AD  - Division of Basic Medical Sciences, Indian Council of Medical Research, Ministry 
      of Health and Family Welfare, Govt. of India, V. Ramalingaswami Bhawan, P.O. Box 
      No. 4911, New Delhi 110029, India.
FAU - Kaushik, Pooja
AU  - Kaushik P
AD  - Department of Toxicology, School of Chemical & Life Sciences, Jamia Hamdard, New 
      Delhi 110062, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220101
PL  - Australia
TA  - Theranostics
JT  - Theranostics
JID - 101552395
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*drug effects
MH  - Drug Administration Routes
MH  - *Drug Delivery Systems
MH  - Forecasting
MH  - Humans
MH  - Ischemic Stroke/drug therapy/physiopathology/*therapy
MH  - Nanoparticles/*therapeutic use
PMC - PMC8692911
OTO - NOTNLM
OT  - Blood brain barrier
OT  - Drug delivery system
OT  - Intranasal drug delivery
OT  - Ischemic stroke
OT  - Nanomedicine
OT  - Neuroprotection
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2022/01/04 06:00
MHDA- 2022/03/11 06:00
PMCR- 2022/01/01
CRDT- 2022/01/03 05:40
PHST- 2021/07/10 00:00 [received]
PHST- 2021/10/14 00:00 [accepted]
PHST- 2022/01/03 05:40 [entrez]
PHST- 2022/01/04 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - thnov12p0689 [pii]
AID - 10.7150/thno.64806 [doi]
PST - epublish
SO  - Theranostics. 2022 Jan 1;12(2):689-719. doi: 10.7150/thno.64806. eCollection 
      2022.