PMID- 34976290 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220429 IS - 1941-2789 (Print) IS - 2689-9175 (Electronic) IS - 1941-2789 (Linking) VI - 14 IP - 10 DP - 2021 Oct TI - Safety and Efficacy of VP-102 (Cantharidin, 0.7% w/v) in Molluscum Contagiosum by Body Region: Post hoc Pooled Analyses from Two Phase III Randomized Trials. PG - 42-47 AB - TRIAL REGISTRATION: >ClinicalTrials.gov identifier nos. NCT03377790 (for CAMP-1) and NCT03377803 (for CAMP-2). BACKGROUND: VP-102 is drug-device combination product containing cantharidin (0.7% w/v) and has undergone Phase III clinical trials for the treatment of molluscum contagiosum (molluscum). Efficacy and safety may differ by body region due to variable skin anatomy. OBJECTIVE: We investigated the pooled safety and efficacy of VP-102 by affected body region. METHODS: Individuals at least two years of age with molluscum were randomized to topical VP-102 or vehicle once every 21 days until clear (maximum of four applications). Participants were assigned to body region groups where lesions were present at baseline. Body region lesion counts were recorded at each visit. Efficacy was measured by the percentage of participants with complete clearance of lesions by region. Pre-specified adverse events (AEs) were analyzed for those treated in the region on that visit. RESULTS: Participants had a mean of two regions affected at baseline. Complete clearance was significantly higher in the VP-102-treated group than with vehicle application in all regions at the last visit (P<0.01 for each region). The incidence of pre-specified AEs was consistent across regions. However, these analyses were post hoc, and individual lesions were not tracked for efficacy. CONCLUSION: VP-102 treatment shows consistent safety and efficacy across molluscum body regions. CI - Copyright (c) 2021. Matrix Medical Communications. All rights reserved. FAU - Eichenfield, Lawrence F AU - Eichenfield LF AD - Dr. Eichenfield is with Rady Children's Hospital and the University of California, San Diego, Medical School in San Diego, California. AD - Dr. Kwong is with Solutions Through Advanced Research in Jacksonville, Florida. AD - Dr. Gonzalez is with the University of Miami Medical School in Miami, Florida. AD - Dr. Yan is with the Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Philadelphia in Philadelphia, Pennsylvania. AD - Mr. D'Arnaud is with Instat Consulting Inc. in Chatham, New Jersey. AD - Drs. Burnett and Olivadoti are former employees of Verrica Pharmaceuticals Inc. in West Chester, Pennsylvania. FAU - Kwong, Pearl AU - Kwong P AD - Dr. Eichenfield is with Rady Children's Hospital and the University of California, San Diego, Medical School in San Diego, California. AD - Dr. Kwong is with Solutions Through Advanced Research in Jacksonville, Florida. AD - Dr. Gonzalez is with the University of Miami Medical School in Miami, Florida. AD - Dr. Yan is with the Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Philadelphia in Philadelphia, Pennsylvania. AD - Mr. D'Arnaud is with Instat Consulting Inc. in Chatham, New Jersey. AD - Drs. Burnett and Olivadoti are former employees of Verrica Pharmaceuticals Inc. in West Chester, Pennsylvania. FAU - Gonzalez, Mercedes E AU - Gonzalez ME AD - Dr. Eichenfield is with Rady Children's Hospital and the University of California, San Diego, Medical School in San Diego, California. AD - Dr. Kwong is with Solutions Through Advanced Research in Jacksonville, Florida. AD - Dr. Gonzalez is with the University of Miami Medical School in Miami, Florida. AD - Dr. Yan is with the Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Philadelphia in Philadelphia, Pennsylvania. AD - Mr. D'Arnaud is with Instat Consulting Inc. in Chatham, New Jersey. AD - Drs. Burnett and Olivadoti are former employees of Verrica Pharmaceuticals Inc. in West Chester, Pennsylvania. FAU - Yan, Albert AU - Yan A AD - Dr. Eichenfield is with Rady Children's Hospital and the University of California, San Diego, Medical School in San Diego, California. AD - Dr. Kwong is with Solutions Through Advanced Research in Jacksonville, Florida. AD - Dr. Gonzalez is with the University of Miami Medical School in Miami, Florida. AD - Dr. Yan is with the Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Philadelphia in Philadelphia, Pennsylvania. AD - Mr. D'Arnaud is with Instat Consulting Inc. in Chatham, New Jersey. AD - Drs. Burnett and Olivadoti are former employees of Verrica Pharmaceuticals Inc. in West Chester, Pennsylvania. FAU - D'Arnaud, Pieter AU - D'Arnaud P AD - Dr. Eichenfield is with Rady Children's Hospital and the University of California, San Diego, Medical School in San Diego, California. AD - Dr. Kwong is with Solutions Through Advanced Research in Jacksonville, Florida. AD - Dr. Gonzalez is with the University of Miami Medical School in Miami, Florida. AD - Dr. Yan is with the Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Philadelphia in Philadelphia, Pennsylvania. AD - Mr. D'Arnaud is with Instat Consulting Inc. in Chatham, New Jersey. AD - Drs. Burnett and Olivadoti are former employees of Verrica Pharmaceuticals Inc. in West Chester, Pennsylvania. FAU - Burnett, Patrick AU - Burnett P AD - Dr. Eichenfield is with Rady Children's Hospital and the University of California, San Diego, Medical School in San Diego, California. AD - Dr. Kwong is with Solutions Through Advanced Research in Jacksonville, Florida. AD - Dr. Gonzalez is with the University of Miami Medical School in Miami, Florida. AD - Dr. Yan is with the Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Philadelphia in Philadelphia, Pennsylvania. AD - Mr. D'Arnaud is with Instat Consulting Inc. in Chatham, New Jersey. AD - Drs. Burnett and Olivadoti are former employees of Verrica Pharmaceuticals Inc. in West Chester, Pennsylvania. FAU - Olivadoti, Melissa AU - Olivadoti M AD - Dr. Eichenfield is with Rady Children's Hospital and the University of California, San Diego, Medical School in San Diego, California. AD - Dr. Kwong is with Solutions Through Advanced Research in Jacksonville, Florida. AD - Dr. Gonzalez is with the University of Miami Medical School in Miami, Florida. AD - Dr. Yan is with the Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Philadelphia in Philadelphia, Pennsylvania. AD - Mr. D'Arnaud is with Instat Consulting Inc. in Chatham, New Jersey. AD - Drs. Burnett and Olivadoti are former employees of Verrica Pharmaceuticals Inc. in West Chester, Pennsylvania. LA - eng SI - ClinicalTrials.gov/NCT03377803 SI - ClinicalTrials.gov/NCT03377790 PT - Journal Article PL - United States TA - J Clin Aesthet Dermatol JT - The Journal of clinical and aesthetic dermatology JID - 101518173 PMC - PMC8711618 OTO - NOTNLM OT - Child OT - VP-102 OT - cantharidin OT - incidence OT - infectious disease OT - lesion OT - molluscum OT - molluscum contagiosum OT - pediatric OT - sensitive skin OT - topical COIS- DISCLOSURES: Dr. Eichenfield received funding to his institution for the described research, has received consulting fees for and stock from Verrica Pharmaceuticals for activities unrelated to this publication, and is a member of the Board of Directors of Verrica Pharmaceuticals. Dr. Kwong has received consulting fees and research funding from Verrica Pharmaceuticals. Dr. Gonzalez has received research funding for the described research and consulting fees from Verrica Pharmaceuticals unrelated to this publication. Dr. Yan has received consulting fees from Verrica Pharmaceuticals for activities unrelated to this publication. Mr. D'Arnaud was a contractor for Verrica Pharmaceuticals. Dr. Burnett was employed by Verrica Pharmaceuticals and holds company stock. Dr. Olivadoti is an employee of Verrica Pharmaceuticals EDAT- 2022/01/04 06:00 MHDA- 2022/01/04 06:01 PMCR- 2021/10/01 CRDT- 2022/01/03 05:41 PHST- 2022/01/03 05:41 [entrez] PHST- 2022/01/04 06:00 [pubmed] PHST- 2022/01/04 06:01 [medline] PHST- 2021/10/01 00:00 [pmc-release] PST - ppublish SO - J Clin Aesthet Dermatol. 2021 Oct;14(10):42-47.