PMID- 34976766 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220429 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 10 IP - 11 DP - 2021 Nov TI - Risk factors for chemotherapy-induced vomiting after general anesthesia in children with retinoblastoma: a retrospective study. PG - 3005-3013 LID - 10.21037/tp-21-245 [doi] AB - BACKGROUND: The chemotherapy-induced vomiting (CIV) severely affects the daily function, nutritional status, treatment compliance, therapeutic efficacy, curability, and the quality of life of patients. The aim of this study was to find the risk factors for CIV after general anesthesia in patients with retinoblastoma (RB). METHODS: A retrospective review of the hospital records of children with RB, who underwent chemotherapy between January 2017 and December 2019, was conducted at our hospital. RESULTS: Data of a total of 803 children with RB were reviewed. The incidence of CIV in children with RB was 19.30%. Univariate analysis showed statistically significant differences in age, height, weight, chemotherapy regimen, anesthesia dose, duration of surgery and general anesthesia, platelet count, platelet distribution width, lymphocytes, and indirect bilirubin between patients with and without vomiting (P<0.05). Multivariate logistic regression analysis showed that the main predictors of CIV in children with RB included older age [odds ratio (OR), 1.32; 95% confidence interval (CI): 1.11-1.56; P<0.01], low platelet count (OR, 0.997; 95% CI: 0.995-0.999; P<0.05), and chemotherapy regimen (intravenous chemotherapy versus intra-arterial chemotherapy; OR, 0.47; 95% CI: 0.29-0.76; P<0.01). CONCLUSIONS: This study revealed age, chemotherapy regimen, and platelet count as risk factors of CIV after general anesthesia in children with RB. Younger age and higher platelet count were protective factors for CIV. Compared with intravenous chemotherapy, the incidence of CIV was lower than that of intra-arterial chemotherapy. Although these factors cannot be modified, they can predict whether a patient may experience vomiting, assisting medical staff to formulate measures and intervenes in advance. KEYWORDS: Retinoblastoma (RB); chemotherapy-induced vomiting (CIV); general anesthesia; multivariate analysis; risk factors. CI - 2021 Translational Pediatrics. All rights reserved. FAU - Zeng, Changjuan AU - Zeng C AD - Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Department of Nursing, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai Jiao Tong University, School of Nursing, Shanghai, China. AD - Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. FAU - Chen, Huifang AU - Chen H AD - Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Department of Nursing, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. FAU - Xu, Yanjuan AU - Xu Y AD - Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Department of Nursing, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. FAU - Ji, Hong AU - Ji H AD - Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Department of Nursing, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. FAU - Du, Na AU - Du N AD - Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Department of Nursing, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. FAU - Song, Xuefei AU - Song X AD - Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. FAU - Hou, Lili AU - Hou L AD - Department of Nursing, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. LA - eng PT - Journal Article PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC8649612 COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi.org/10.21037/tp-21-245). The authors have no conflicts of interest to declare. EDAT- 2022/01/04 06:00 MHDA- 2022/01/04 06:01 PMCR- 2021/11/01 CRDT- 2022/01/03 05:46 PHST- 2021/05/31 00:00 [received] PHST- 2021/08/05 00:00 [accepted] PHST- 2022/01/03 05:46 [entrez] PHST- 2022/01/04 06:00 [pubmed] PHST- 2022/01/04 06:01 [medline] PHST- 2021/11/01 00:00 [pmc-release] AID - tp-10-11-3005 [pii] AID - 10.21037/tp-21-245 [doi] PST - ppublish SO - Transl Pediatr. 2021 Nov;10(11):3005-3013. doi: 10.21037/tp-21-245.