PMID- 34978743 OWN - NLM STAT- MEDLINE DCOM- 20220301 LR - 20220301 IS - 1096-8652 (Electronic) IS - 0361-8609 (Linking) VI - 97 IP - 3 DP - 2022 Mar 1 TI - Impact of achieving a complete response to initial therapy of multiple myeloma and predictors of subsequent outcome. PG - 267-273 LID - 10.1002/ajh.26439 [doi] AB - Achievement of a complete response (CR) in multiple myeloma (MM) correlates with improvement in survival outcomes; however, its impact on prognostic variables at baseline outside of clinical trial settings is not well described. We sought to determine the impact of achieving a CR within 2 years from diagnosis, its effect on the prognostic value of fluorescence in situ hybridization (FISH) and International Staging System (ISS) risk, and examined additional predictors of outcome among those achieving a CR in a routine clinical setting. We evaluated 1869 newly diagnosed MM patients who had >/= 2 monoclonal protein immunofixation studies in the serum and urine available within 24 months from diagnosis, categorizing those with >/= 2 negative serum and urine immunofixations as achieving CR. With a landmark at 24 months, median progression-free survival (PFS) for CR versus non-CR patients was 29.8 versus 20.9 months (p 75 years, male gender, hypoalbuminemia, and non-immunoglobulin G involved heavy chain. Our study confirms that achievement of CR within 2 years from diagnosis is associated with improvement in survival outcomes and neutralization of the impact of FISH and ISS risk, thereby confirming observations from the clinical trial setting among a clinical practice cohort. CI - (c) 2022 Wiley Periodicals LLC. FAU - Kaddoura, Marcella AU - Kaddoura M AUID- ORCID: 0000-0002-4529-7405 AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Binder, Moritz AU - Binder M AUID- ORCID: 0000-0001-9014-9658 AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Dingli, David AU - Dingli D AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Buadi, Francis K AU - Buadi FK AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Lacy, Martha Q AU - Lacy MQ AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Gertz, Morie A AU - Gertz MA AUID- ORCID: 0000-0002-3853-5196 AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Dispenzieri, Angela AU - Dispenzieri A AUID- ORCID: 0000-0001-8780-9512 AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Kapoor, Prashant AU - Kapoor P AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Hwa, Lisa AU - Hwa L AUID- ORCID: 0000-0002-8163-2979 AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Fonder, Amie AU - Fonder A AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Hobbs, Miriam AU - Hobbs M AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Hayman, Suzanne AU - Hayman S AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Leung, Nelson AU - Leung N AUID- ORCID: 0000-0002-5651-1411 AD - Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Go, Ronald S AU - Go RS AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Lin, Yi AU - Lin Y AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Gonsalves, Wilson AU - Gonsalves W AUID- ORCID: 0000-0001-6890-969X AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Kourelis, Taxiarchis AU - Kourelis T AUID- ORCID: 0000-0001-8573-9434 AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Warsame, Rahma AU - Warsame R AUID- ORCID: 0000-0003-0240-0326 AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Kyle, Robert A AU - Kyle RA AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Rajkumar, Vincent AU - Rajkumar V AUID- ORCID: 0000-0002-5862-1833 AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Kumar, Shaji AU - Kumar S AUID- ORCID: 0000-0001-5392-9284 AD - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. LA - eng PT - Journal Article DEP - 20220103 PL - United States TA - Am J Hematol JT - American journal of hematology JID - 7610369 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Disease-Free Survival MH - Female MH - Humans MH - In Situ Hybridization, Fluorescence MH - Male MH - Middle Aged MH - *Multiple Myeloma/mortality/therapy/urine MH - Remission Induction MH - Retrospective Studies MH - Survival Rate EDAT- 2022/01/04 06:00 MHDA- 2022/03/03 06:00 CRDT- 2022/01/03 12:19 PHST- 2021/12/05 00:00 [revised] PHST- 2021/10/20 00:00 [received] PHST- 2021/12/15 00:00 [accepted] PHST- 2022/01/04 06:00 [pubmed] PHST- 2022/03/03 06:00 [medline] PHST- 2022/01/03 12:19 [entrez] AID - 10.1002/ajh.26439 [doi] PST - ppublish SO - Am J Hematol. 2022 Mar 1;97(3):267-273. doi: 10.1002/ajh.26439. Epub 2022 Jan 3.