PMID- 34979254
OWN - NLM
STAT- MEDLINE
DCOM- 20220428
LR  - 20220428
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Linking)
VI  - 90
DP  - 2022 Mar-Apr
TI  - Neurobehavioral and neurochemical effects of perinatal arsenite exposure in 
      Sprague-Dawley rats.
PG  - 107059
LID - S0892-0362(21)00113-6 [pii]
LID - 10.1016/j.ntt.2021.107059 [doi]
AB  - Exposure to relatively high levels of inorganic arsenic (iAs) is associated with 
      detrimental effects on human health, including cancer and diabetes. The effects 
      of lower-level exposures are less clear, and gaps in the literature exist as to 
      the effects of iAs exposure on neurodevelopment. The current study assessed the 
      effects of perinatal iAs exposure on rodent neurodevelopment and behavior. 
      Pregnant Sprague-Dawley (SD) rats were exposed to arsenite (AsIII) via oral 
      gavage on gestational days (GD) 6 through 21, and pups were directly dosed via 
      gavage on postnatal days (PND) 1 through 21. Dams and offspring received the same 
      doses: 0.00, 0.10, 1.50, or 3.75 mg/kg/day. Male and female offspring underwent a 
      battery of behavioral assessments from weaning until PND 180. Brain arsenic 
      levels increased in a dose-dependent manner at both PND 1 and 21. Results from 
      the behavioral tests show that pre- and postnatal AsIII exposure did not 
      adversely affect offspring weight gain, adolescent motor and cognitive functions, 
      or adult motor and cognitive functions in the SD rat. There were no differences 
      in concentration of several brain proteins associated with blood-brain barrier 
      permeability, dopamine functions, and inflammation.
CI  - Published by Elsevier Inc.
FAU - Flanigan, Timothy J
AU  - Flanigan TJ
AD  - Division of Neurotoxicology, National Center for Toxicological Research/FDA, 
      Jefferson, AR 72079, United States of America.
FAU - Ferguson, Sherry A
AU  - Ferguson SA
AD  - Division of Neurotoxicology, National Center for Toxicological Research/FDA, 
      Jefferson, AR 72079, United States of America.
FAU - Law, Charles D
AU  - Law CD
AD  - Division of Neurotoxicology, National Center for Toxicological Research/FDA, 
      Jefferson, AR 72079, United States of America.
FAU - Rosas-Hernandez, Hector
AU  - Rosas-Hernandez H
AD  - Division of Neurotoxicology, National Center for Toxicological Research/FDA, 
      Jefferson, AR 72079, United States of America.
FAU - Cuevas-Martinez, Elvis
AU  - Cuevas-Martinez E
AD  - Division of Neurotoxicology, National Center for Toxicological Research/FDA, 
      Jefferson, AR 72079, United States of America.
FAU - Fitzpatrick, Suzanne
AU  - Fitzpatrick S
AD  - Office of the Center Director, Center for Food Safety and Applied Nutrition/FDA, 
      , United States of America.
FAU - Shen, Andrew N
AU  - Shen AN
AD  - Division of Neurotoxicology, National Center for Toxicological Research/FDA, 
      Jefferson, AR 72079, United States of America. Electronic address: 
      Andrew.Shen@fda.hhs.gov.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20211231
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Arsenites)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Animals
MH  - *Arsenic
MH  - *Arsenites/metabolism/toxicity
MH  - Behavior, Animal
MH  - Brain
MH  - Female
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Developmental toxicity
OT  - Inorganic arsenic
OT  - Neurobehavioral assessment
EDAT- 2022/01/04 06:00
MHDA- 2022/04/29 06:00
CRDT- 2022/01/03 20:14
PHST- 2021/08/17 00:00 [received]
PHST- 2021/12/13 00:00 [revised]
PHST- 2021/12/15 00:00 [accepted]
PHST- 2022/01/04 06:00 [pubmed]
PHST- 2022/04/29 06:00 [medline]
PHST- 2022/01/03 20:14 [entrez]
AID - S0892-0362(21)00113-6 [pii]
AID - 10.1016/j.ntt.2021.107059 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2022 Mar-Apr;90:107059. doi: 10.1016/j.ntt.2021.107059. 
      Epub 2021 Dec 31.