PMID- 3497985
OWN - NLM
STAT- MEDLINE
DCOM- 19871015
LR  - 20061115
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 139
IP  - 6
DP  - 1987 Sep 15
TI  - Isotype concentrations of human antibodies to Haemophilus influenzae type b 
      polysaccharide (Hib) in young adults immunized with the polysaccharide as such or 
      conjugated to a protein (diphtheria toxoid).
PG  - 1999-2004
AB  - Antibody responses of young adults to Haemophilus influenzae type b 
      polysaccharide (Hib) or its protein conjugate were studied with special attention 
      to the isotype composition of the antibodies. Three conclusions of interest can 
      be made: 1) Immunoglobulin G (IgG) antibodies in polysaccharide-immunized 
      volunteers displayed the subclass pattern previously found in antibodies to 
      meningococcal type A polysaccharide. IgG1 was the predominant subclass in IgG 
      antibodies of some individuals, IgG2 in others. Still others had the two 
      subclasses in varying but more even proportions. 2) The conjugate vaccine induced 
      a geometric mean response 2 to 3 times higher and an IgG response 4 times higher 
      to Hib than the polysaccharide vaccine. 3) Anti-Hib antibodies induced by the 
      conjugate vaccine still had essentially the same IgG subclass composition as 
      anti-Hib antibodies induced by the polysaccharide. This composition was 
      strikingly different from the composition of the anti-diphtheria toxoid response 
      induced by the same conjugate vaccine.
FAU - Makela, O
AU  - Makela O
FAU - Mattila, P
AU  - Mattila P
FAU - Rautonen, N
AU  - Rautonen N
FAU - Seppala, I
AU  - Seppala I
FAU - Eskola, J
AU  - Eskola J
FAU - Kayhty, H
AU  - Kayhty H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Bacterial Vaccines)
RN  - 0 (Diphtheria Toxoid)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin Isotypes)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Polysaccharides, Bacterial)
SB  - IM
MH  - Antibodies, Bacterial/*immunology
MH  - Bacterial Vaccines/immunology
MH  - Diphtheria Toxoid/immunology
MH  - Haemophilus influenzae/*immunology
MH  - Humans
MH  - Immunoglobulin A/biosynthesis
MH  - Immunoglobulin G/biosynthesis
MH  - Immunoglobulin Isotypes/*immunology
MH  - Immunoglobulin M/biosynthesis
MH  - Polysaccharides, Bacterial/*immunology
EDAT- 1987/09/15 00:00
MHDA- 1987/09/15 00:01
CRDT- 1987/09/15 00:00
PHST- 1987/09/15 00:00 [pubmed]
PHST- 1987/09/15 00:01 [medline]
PHST- 1987/09/15 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1987 Sep 15;139(6):1999-2004.