PMID- 34980092
OWN - NLM
STAT- MEDLINE
DCOM- 20220106
LR  - 20231105
IS  - 2662-7671 (Electronic)
IS  - 2662-7671 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Jan 3
TI  - Economic evaluation of a national vitamin D supplementation program among Iranian 
      adolescents for the prevention of adulthood type 2 diabetes mellitus.
PG  - 1
LID - 10.1186/s12906-021-03474-0 [doi]
LID - 1
AB  - BACKGROUND: This study aimed to evaluate the cost-effectiveness of vitamin D 
      supplementation in preventing type 2 diabetes mellitus (T2DM) among Iranian 
      adolescents. METHODS: This analytical observational study was conducted, using 
      the decision tree model constructed in TreeAge Pro to assess the cost per 
      quality-adjusted life-year (QALY) of monthly intake vitamin D supplements to 
      prevent T2DM compared to no intervention from the viewpoint of Iran's Ministry of 
      Health and through an one-year horizon. In the national program of vitamin D 
      supplementation, 1,185,211 Iranian high-school students received 50,000 IU 
      vitamin D supplements monthly for nine months. The costs-related data were 
      modified to 2018. The average cost and effectiveness were compared based on the 
      Incremental Cost-Effectiveness Ratio (ICER). RESULTS: Our analytical analysis 
      estimated the 4071.25 (USD / QALY) cost per AQALY gained of the monthly intake of 
      50,000 IU vitamin D for nine months among adolescents over a one-year horizon. 
      Based on the ICER threshold of 1032-2666, vitamin D supplementation was 
      cost-effective for adolescents to prevent adulthood T2DM. It means that vitamin D 
      supplementation costs were substantially less than the costs of T2DM treatments 
      than the no intervention. CONCLUSIONS: Based on the findings, the national 
      vitamin D supplementation program for Iranian adolescents could be a 
      cost-effective strategy to reduce the risk of diabetes in adulthood. From an 
      economic perspective, vitamin D supplementation, especially in adolescents with 
      vitamin D deficiency, would be administrated.
CI  - (c) 2021. The Author(s).
FAU - Zandieh, Narges
AU  - Zandieh N
AD  - Faculty of pharmacy, Tehran Medical sciences, Islamic Azad University, Tehran, 
      Iran.
FAU - Hemami, Mohsen Rezaei
AU  - Hemami MR
AD  - University of Aberdeen, Aberdeen Centre for Health Data Sciences, Aberdeen, UK.
FAU - Darvishi, Ali
AU  - Darvishi A
AD  - Department of Management and Health Economics, School of Public Health, Tehran 
      University of Medical Sciences (TUMS), Tehran, Iran.
FAU - Hasheminejad, Seyed Mohammad
AU  - Hasheminejad SM
AD  - Department of Management, Medical Science Branch, Islamic Azad University, 
      Tehran, Iran.
FAU - Abdollahi, Zahra
AU  - Abdollahi Z
AD  - Office of Community Nutrition, Deputy of Health, Iran Ministry of Health and 
      Medical Education, Tehran, Iran.
FAU - Zarei, Maryam
AU  - Zarei M
AD  - Office of Community Nutrition, Deputy of Health, Iran Ministry of Health and 
      Medical Education, Tehran, Iran.
FAU - Heshmat, Ramin
AU  - Heshmat R
AD  - Chronic Diseases Research Center, Endocrinology and Metabolism Population 
      Sciences Institute, Tehran University of Medical Sciences, Tehran, 1941933111, 
      Iran. r_heshmat@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20220103
PL  - England
TA  - BMC Complement Med Ther
JT  - BMC complementary medicine and therapies
JID - 101761232
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adolescent
MH  - Diabetes Mellitus, Type 2/etiology/*prevention & control
MH  - Dietary Supplements/*economics
MH  - Humans
MH  - Iran
MH  - National Health Programs/*economics
MH  - Vitamin D/*administration & dosage
PMC - PMC8722369
OTO - NOTNLM
OT  - Cost-effectiveness
OT  - Diabetes management
OT  - National program
OT  - Vitamin D supplementation
COIS- Not applicable.
EDAT- 2022/01/05 06:00
MHDA- 2022/01/07 06:00
PMCR- 2022/01/03
CRDT- 2022/01/04 05:42
PHST- 2021/03/27 00:00 [received]
PHST- 2021/12/02 00:00 [accepted]
PHST- 2022/01/04 05:42 [entrez]
PHST- 2022/01/05 06:00 [pubmed]
PHST- 2022/01/07 06:00 [medline]
PHST- 2022/01/03 00:00 [pmc-release]
AID - 10.1186/s12906-021-03474-0 [pii]
AID - 3474 [pii]
AID - 10.1186/s12906-021-03474-0 [doi]
PST - epublish
SO  - BMC Complement Med Ther. 2022 Jan 3;22(1):1. doi: 10.1186/s12906-021-03474-0.