PMID- 34981013
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231108
IS  - 2322-3480 (Print)
IS  - 2322-3480 (Electronic)
IS  - 2322-3480 (Linking)
VI  - 10
IP  - 3
DP  - 2021 Oct
TI  - The Benefits of Curcuminoid to Expression Nuclear Factor Erythroid 2 Related 
      Factor 2 (NRF2) and Signal to Noise Ratio (SNR) Value in the Noise Exposed Organ 
      of Corti of Rattus Norvegicus.
PG  - 373-379
LID - 10.52547/rbmb.10.3.373 [doi]
AB  - BACKGROUND: Noise-induced hearing loss (NIHL) can cause damage to the cochlea. 
      Curcumin and nuclear factor erythroid 2-related factor 2 (NRF2) are transcription 
      activators that play a crucial role in defence mechanisms against oxidative 
      stress. The aim of this study was to determine the effect of curcuminoid 
      administration on NRF2 expression, in the organ of Corti of cochlea of Rattus 
      norvegicus that were exposed to noise, from the results of the distortion product 
      otoacoustic emission (DPOAE) examination. METHODS: We divided 36 rats into six 
      groups including Group 1 (control); Group 2 (noise exposure without curcuminoid 
      administration); Group 3 (noise exposure+curcuminoid dose 100 mg/day for four 
      days); Group 4 (noise exposure+curcuminoid dose 200 mg/day for four days); Group 
      5 (curcuminoid dose of 100 mg/day for 14 days followed by two days of noise 
      exposure); Group 6 (curcuminoid dose 200 mg/day for 14 days followed by two days 
      of noise exposure). RESULTS: Following noise exposure in rats, there was an 
      effect/correlation between NRF2 expression, the SNR values obtained from DPOAE 
      and curcuminoid administration. CONCLUSION: There was a correlation between 
      curcuminoid administration, NRF2 expression and DPOAE treatment. Following noise 
      exposure in rats (Rattus norvegicus), SNR values obtained from DPOAE showed 
      improved cochlear function.
FAU - Haryuna, Tengku Siti Hajar
AU  - Haryuna TSH
AD  - Department of Otorhinolaryngology, Faculty of medicine, Universitas Sumatera 
      Utara, Medan, Sumatera Utara, 20155, Indonesia.
FAU - Amellya, Diana
AU  - Amellya D
AD  - Department of Otorhinolaryngology, Faculty of medicine, Universitas Sumatera 
      Utara, Medan, Sumatera Utara, 20155, Indonesia.
FAU - Munir, Delfitri
AU  - Munir D
AD  - Department of Otorhinolaryngology, Faculty of medicine, Universitas Sumatera 
      Utara, Medan, Sumatera Utara, 20155, Indonesia.
FAU - Zubaidah, Tengku Siti Harilza
AU  - Zubaidah TSH
AD  - Department of Ophtalmology, Faculty of medicine, Universitas Sumatera Utara, 
      Medan, Sumatera Utara, 20155, Indonesia.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Rep Biochem Mol Biol
JT  - Reports of biochemistry & molecular biology
JID - 101637937
PMC - PMC8718775
OTO - NOTNLM
OT  - Curcuminoid
OT  - Distortion Product Otoacoustic Emission
OT  - Noise Induced Hearing Loss
OT  - Nuclear factor erythroid 2-related factor 2
OT  - Oxidative Stress
EDAT- 2022/01/05 06:00
MHDA- 2022/01/05 06:01
PMCR- 2021/10/01
CRDT- 2022/01/04 06:07
PHST- 2021/02/17 00:00 [received]
PHST- 2021/04/06 00:00 [accepted]
PHST- 2022/01/04 06:07 [entrez]
PHST- 2022/01/05 06:00 [pubmed]
PHST- 2022/01/05 06:01 [medline]
PHST- 2021/10/01 00:00 [pmc-release]
AID - rbmb-10-373 [pii]
AID - 10.52547/rbmb.10.3.373 [doi]
PST - ppublish
SO  - Rep Biochem Mol Biol. 2021 Oct;10(3):373-379. doi: 10.52547/rbmb.10.3.373.