PMID- 34981128
OWN - NLM
STAT- MEDLINE
DCOM- 20230203
LR  - 20230203
IS  - 1615-6692 (Electronic)
IS  - 0340-9937 (Linking)
VI  - 48
IP  - 1
DP  - 2023 Feb
TI  - Effects of TCFA on stent neointimal coverage at 9 months after EXCEL drug-eluting 
      stent implantation assessed by OCT.
PG  - 64-71
LID - 10.1007/s00059-021-05095-2 [doi]
AB  - BACKGROUND: The aim of this study was to investigate the effects of thin-cap 
      fibroatheromas (TCFAs) on stent neointimal coverage at the 9‑month follow-up 
      after EXCEL stent implantation assessed by optical coherence tomography (OCT). 
      METHODS: A total of 93 patients with non-ST elevation acute coronary syndrome 
      (NSTEACS) who underwent EXCEL stent implantation were prospectively enrolled in 
      the study and divided into a TCFA group (n = 47) and a non-TCFA group (n = 46) 
      according to whether EXCEL stents covered the TCFAs. A TCFA was defined as 
      a plaque with lipid content in more than one quadrant and fibrous cap thickness 
      measuring less than 65 mum. The effect of TCFAs on stent neointimal coverage at 
      the 9‑month follow-up after stent implantation was evaluated by OCT. The primary 
      study endpoints were the incidence of neointimal uncoverage and stent 
      malapposition. RESULTS: At the 9‑month follow-up, the minimal lumen diameter of 
      the TCFA group tended to be smaller (2.8 +/- 0.8 vs. 2.1 +/- 0.8, p = 0.08) and the 
      diameter of stenosis in the TCFA group tended to be larger (15.1 +/- 10.3% vs. 
      26.3 +/- 15.1%, p = 0.08) than those in the non-TCFA group. The mean intimal 
      thickness of the TCFA group was significantly lower than that of the non-TCFA 
      group (67.2 +/- 35.5 vs. 145.1 +/- 48.7, p < 0.001). The uncovered struts (10.1 +/- 9.7 
      vs. 4.8 +/- 4.3, p = 0.05) and malapposed struts (2.1 +/- 4.7 vs. 0.3 +/- 0.5, 
      p = 0.003) in the TCFA group were more significant than those in the non-TCFA 
      group. Multivariate analysis showed that TCFAs and lesion types were independent 
      predictors of incomplete neointimal coverage (p < 0.05), and lesion types were 
      independent predictors of stent malapposition (p < 0.05). CONCLUSION: In patients 
      with NSTEACS, TCFAs delayed endothelium coverage at 9 months after stent 
      implantation, and TCFAs were independent predictors of incomplete neointimal 
      coverage of the stent.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, 
      ein Teil von Springer Nature.
FAU - Zhang, Jiao
AU  - Zhang J
AD  - Department of Cardiology, Beijing Electric Power Hospital, State Grid 
      Corporation, Beijing, China.
AD  - Department of Cardiology, The Third Medical Center of Chinese PLA General 
      Hospital, No.69 Yongding Road, Haidian District, 100089, Beijing, China.
FAU - Duan, Yuanyuan
AU  - Duan Y
AD  - Department of Geriatrics, The Second Medical Center & National Clinical Research 
      Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
FAU - Yu, Hong
AU  - Yu H
AD  - Department of Cardiology, Beijing Electric Power Hospital, State Grid 
      Corporation, Beijing, China.
FAU - Jing, Limin
AU  - Jing L
AD  - Department of Cardiology, Beijing Electric Power Hospital, State Grid 
      Corporation, Beijing, China.
FAU - Li, Yi
AU  - Li Y
AD  - Department of Cardiology, The Third Medical Center of Chinese PLA General 
      Hospital, No.69 Yongding Road, Haidian District, 100089, Beijing, China.
FAU - Jia, Xiaowei
AU  - Jia X
AD  - Department of Cardiology, The Third Medical Center of Chinese PLA General 
      Hospital, No.69 Yongding Road, Haidian District, 100089, Beijing, China.
FAU - Jin, Dekui
AU  - Jin D
AD  - Department of Cardiology, The Third Medical Center of Chinese PLA General 
      Hospital, No.69 Yongding Road, Haidian District, 100089, Beijing, China.
FAU - Liu, Huiliang
AU  - Liu H
AD  - Department of Cardiology, Beijing Electric Power Hospital, State Grid 
      Corporation, Beijing, China. 876722113@qq.com.
AD  - Department of Cardiology, The Third Medical Center of Chinese PLA General 
      Hospital, No.69 Yongding Road, Haidian District, 100089, Beijing, China. 
      876722113@qq.com.
LA  - eng
GR  - Z161100000516091/beijing municipal science and technology project/
PT  - Journal Article
TT  - Auswirkungen von TCFA auf die neointimale Abdeckung des Stents 9 Monate nach 
      Implantation eines medikamentenfreisetzenden EXCEL-Stents, bewertet durch OCT.
DEP - 20220103
PL  - Germany
TA  - Herz
JT  - Herz
JID - 7801231
SB  - IM
MH  - Humans
MH  - *Drug-Eluting Stents
MH  - *Coronary Artery Disease/diagnostic imaging/surgery
MH  - Tomography, Optical Coherence/methods
MH  - Treatment Outcome
MH  - Stents
MH  - *Atherosclerosis
MH  - Neointima/diagnostic imaging/pathology
MH  - *Percutaneous Coronary Intervention
MH  - *Acute Coronary Syndrome/diagnostic imaging/surgery
MH  - Coronary Vessels/diagnostic imaging/surgery
OTO - NOTNLM
OT  - Malapposition
OT  - Neointimal coverage
OT  - Non-ST-elevation acute coronary syndrome
OT  - Optical coherence tomography
OT  - Thin-cap fibroatheroma
EDAT- 2022/01/05 06:00
MHDA- 2023/02/04 06:00
CRDT- 2022/01/04 06:10
PHST- 2021/08/01 00:00 [received]
PHST- 2021/11/30 00:00 [accepted]
PHST- 2021/10/11 00:00 [revised]
PHST- 2022/01/05 06:00 [pubmed]
PHST- 2023/02/04 06:00 [medline]
PHST- 2022/01/04 06:10 [entrez]
AID - 10.1007/s00059-021-05095-2 [pii]
AID - 10.1007/s00059-021-05095-2 [doi]
PST - ppublish
SO  - Herz. 2023 Feb;48(1):64-71. doi: 10.1007/s00059-021-05095-2. Epub 2022 Jan 3.