PMID- 34981187
OWN - NLM
STAT- MEDLINE
DCOM- 20220504
LR  - 20231105
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 74
IP  - 1
DP  - 2022 Feb
TI  - Structural basis of NLR activation and innate immune signalling in plants.
PG  - 5-26
LID - 10.1007/s00251-021-01242-5 [doi]
AB  - Animals and plants have NLRs (nucleotide-binding leucine-rich repeat receptors) 
      that recognize the presence of pathogens and initiate innate immune responses. In 
      plants, there are three types of NLRs distinguished by their N-terminal domain: 
      the CC (coiled-coil) domain NLRs, the TIR (Toll/interleukin-1 receptor) domain 
      NLRs and the RPW8 (resistance to powdery mildew 8)-like coiled-coil domain NLRs. 
      CC-NLRs (CNLs) and TIR-NLRs (TNLs) generally act as sensors of effectors secreted 
      by pathogens, while RPW8-NLRs (RNLs) signal downstream of many sensor NLRs and 
      are called helper NLRs. Recent studies have revealed three dimensional structures 
      of a CNL (ZAR1) including its inactive, intermediate and active oligomeric state, 
      as well as TNLs (RPP1 and ROQ1) in their active oligomeric states. Furthermore, 
      accumulating evidence suggests that members of the family of lipase-like EDS1 
      (enhanced disease susceptibility 1) proteins, which are uniquely found in seed 
      plants, play a key role in providing a link between sensor NLRs and helper NLRs 
      during innate immune responses. Here, we summarize the implications of the plant 
      NLR structures that provide insights into distinct mechanisms of action by the 
      different sensor NLRs and discuss plant NLR-mediated innate immune signalling 
      pathways involving the EDS1 family proteins and RNLs.
CI  - (c) 2021. The Author(s).
FAU - Maruta, Natsumi
AU  - Maruta N
AUID- ORCID: 0000-0002-6246-6346
AD  - School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience 
      and Australian Infectious Diseases Research Centre, University of Queensland, 
      Brisbane, QLD, 4072, Australia. n.maruta@uq.edu.au.
FAU - Burdett, Hayden
AU  - Burdett H
AUID- ORCID: 0000-0003-4803-9660
AD  - School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience 
      and Australian Infectious Diseases Research Centre, University of Queensland, 
      Brisbane, QLD, 4072, Australia.
AD  - Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann 
      Building, Max Born Crescent, Edinburgh, UK.
FAU - Lim, Bryan Y J
AU  - Lim BYJ
AUID- ORCID: 0000-0002-0554-909X
AD  - School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience 
      and Australian Infectious Diseases Research Centre, University of Queensland, 
      Brisbane, QLD, 4072, Australia.
FAU - Hu, Xiahao
AU  - Hu X
AUID- ORCID: 0000-0002-2587-7875
AD  - School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience 
      and Australian Infectious Diseases Research Centre, University of Queensland, 
      Brisbane, QLD, 4072, Australia.
FAU - Desa, Sneha
AU  - Desa S
AD  - School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience 
      and Australian Infectious Diseases Research Centre, University of Queensland, 
      Brisbane, QLD, 4072, Australia.
FAU - Manik, Mohammad Kawsar
AU  - Manik MK
AUID- ORCID: 0000-0001-9510-2250
AD  - School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience 
      and Australian Infectious Diseases Research Centre, University of Queensland, 
      Brisbane, QLD, 4072, Australia.
FAU - Kobe, Bostjan
AU  - Kobe B
AUID- ORCID: 0000-0001-9413-9166
AD  - School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience 
      and Australian Infectious Diseases Research Centre, University of Queensland, 
      Brisbane, QLD, 4072, Australia. b.kobe@uq.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220104
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (NLR Proteins)
RN  - 0 (Proteins)
SB  - IM
MH  - Animals
MH  - Immunity, Innate
MH  - *NLR Proteins/chemistry/metabolism
MH  - *Plant Immunity
MH  - Plants/metabolism
MH  - Proteins
MH  - Signal Transduction
PMC - PMC8813719
OTO - NOTNLM
OT  - CC domain
OT  - EDS1
OT  - NLR
OT  - Plant innate immunity
OT  - RNL
OT  - TIR domain
COIS- The authors declare no competing interests.
EDAT- 2022/01/05 06:00
MHDA- 2022/05/06 06:00
PMCR- 2022/01/04
CRDT- 2022/01/04 06:12
PHST- 2021/09/18 00:00 [received]
PHST- 2021/11/29 00:00 [accepted]
PHST- 2022/01/05 06:00 [pubmed]
PHST- 2022/05/06 06:00 [medline]
PHST- 2022/01/04 06:12 [entrez]
PHST- 2022/01/04 00:00 [pmc-release]
AID - 10.1007/s00251-021-01242-5 [pii]
AID - 1242 [pii]
AID - 10.1007/s00251-021-01242-5 [doi]
PST - ppublish
SO  - Immunogenetics. 2022 Feb;74(1):5-26. doi: 10.1007/s00251-021-01242-5. Epub 2022 
      Jan 4.