PMID- 34983108
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220113
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 14
IP  - 1
DP  - 2022 Jan
TI  - Natural History and Influencing Factors of Chronic Urticaria in Children.
PG  - 73-84
LID - 10.4168/aair.2022.14.1.73 [doi]
AB  - PURPOSE: Chronic urticaria (CU) can reduce the quality of life of children and 
      their parents, but there are only a few studies on the course of CU in children. 
      This study aimed to investigate the natural course of CU in children and identify 
      the factors that influence its prognosis. METHODS: We evaluated 77 children 
      diagnosed with CU, who were monitored for at least 48 months. Subjects were 
      classified as either chronic spontaneous urticaria (CSU) or other CU, and the 
      clinical features were compared. Remission was defined as having no symptoms 
      without treatment for more than 1 year. The remission rate was analyzed, and the 
      factors influencing the prognosis were investigated. RESULTS: The average age of 
      the study population was 5.96 +/- 4.06 years, and 64 (83.1%) patients had CSU. The 
      remission rates at 6 months, 1 year, 2 years, 3 years, and 4 years after symptom 
      onset were 22.1%, 40.3%, 52.0%, 63.7%, and 70.2%, respectively, for children with 
      CU. For children with CSU, these values were 23.4%, 43.7%, 56.2%, 68.7%, and 
      75.0%, respectively. The total serum immunoglobulin E (IgE) levels were 
      positively correlated with disease duration (r = 0.262, P = 0.021); no other 
      factors were associated with the duration of the disease. CONCLUSIONS: A high 
      proportion of children with CU were classified as CSU. No indicators, except for 
      total IgE were found to predict the timing of spontaneous remission. The CU 
      remission rate identified in this study is expected to be used as one of the 
      reference data for the progress of CU in patients.
CI  - Copyright (c) 2022 The Korean Academy of Asthma, Allergy and Clinical Immunology * 
      The Korean Academy of Pediatric Allergy and Respiratory Disease.
FAU - Kim, Hyeon A
AU  - Kim HA
AUID- ORCID: 0000-0001-9843-0188
AD  - Department of Pediatrics, School of Medicine, Kyungpook National University, 
      Daegu, Korea.
FAU - Hyun, Myung Chul
AU  - Hyun MC
AUID- ORCID: 0000-0001-9525-3585
AD  - Department of Pediatrics, School of Medicine, Kyungpook National University, 
      Daegu, Korea.
FAU - Choi, Bong Seok
AU  - Choi BS
AUID- ORCID: 0000-0002-2129-7232
AD  - Department of Pediatrics, School of Medicine, Kyungpook National University, 
      Daegu, Korea. bschoi@knu.ac.kr.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC8724829
OTO - NOTNLM
OT  - Chronic urticaria
OT  - child
OT  - chronic inducible urticaria
OT  - chronic spontaneous urticaria
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2022/01/05 06:00
MHDA- 2022/01/05 06:01
PMCR- 2022/01/01
CRDT- 2022/01/04 20:10
PHST- 2021/01/20 00:00 [received]
PHST- 2021/07/26 00:00 [revised]
PHST- 2021/09/01 00:00 [accepted]
PHST- 2022/01/04 20:10 [entrez]
PHST- 2022/01/05 06:00 [pubmed]
PHST- 2022/01/05 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 14.73 [pii]
AID - 10.4168/aair.2022.14.1.73 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2022 Jan;14(1):73-84. doi: 10.4168/aair.2022.14.1.73.