PMID- 34983149
OWN - NLM
STAT- MEDLINE
DCOM- 20220106
LR  - 20220531
IS  - 1681-7168 (Electronic)
IS  - 1022-386X (Linking)
VI  - 32
IP  - 1
DP  - 2022 Jan
TI  - Relationship among Serum Homocysteine, Intercellular Adhesion Molecule-1, 
      Monocyte Chemoattractant Protein-1, and Visual Impairment in Diabetic Macular 
      Edema.
PG  - 57-60
LID - 10.29271/jcpsp.2022.01.57 [doi]
AB  - OBJECTIVE: To determine the relationship among serum homocysteine (Hcy), 
      intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 
      (MCP-1) and visual impairment in patients with diabetic macular edema (DME). 
      STUDY DESIGN: Cross-sectional analytical study. PLACE AND DURATION OF STUDY: 
      Yulin Second Hospital, China, from April 2018 to May 2021. METHODOLOGY: A total 
      of 132 patients with diabetic retinopathy (DR), complicated with DME, were 
      selected as observation group; and 132 patients with simple DR were included in 
      the control group. According to visual examination, patients in observation group 
      were divided into visual disability and non-visual disability. Serum Hcy, ICAM-1, 
      MCP-1, and other indicators were measured. RESULTS: Duration of diabetes, levels 
      of serum Hcy, ICAM-1 and MCP-1 in observation group were higher than those in 
      control group (all p <0.001). Levels of serum Hcy, ICAM-1 and MCP-1 in patients 
      with mild, moderate and severe DME were significantly different (all p <0.001). 
      Levels of serum Hcy, ICAM-1 and MCP-1 in patients with visual disabilities were 
      higher than those in patients with non-visual disabilities (all p <0.001). Levels 
      of serum Hcy, ICAM-1 and MCP-1 in visually disabled patients were higher than 
      those in non-visual disability patients (all p <0.001). CONCLUSION: Levels of 
      serum Hcy, ICAM-1 and MCP-1 in patients with DR complicated with DME were higher 
      than those without visual disability; and levels of Hcy, ICAM-1 and MCP-1 in 
      patients with visual disability were higher than those without visual disability. 
      In patients with DR complicated with DME, increase of these serum markers may 
      play an important role in visual disability. Key Words: Diabetic retinopathy 
      (DR), Diabetic macular edema (DME), Hcy, ICAM-1, MCP-1, Visual impairment.
FAU - Fu, Jinjing
AU  - Fu J
AD  - Department of Ophthalmology, Yulin Second Hospital, Taiyuan, Shaanxi Province, 
      China.
FAU - Zhu, Jiali
AU  - Zhu J
AD  - Department of Ophthalmology, Yulin Second Hospital, Taiyuan, Shaanxi Province, 
      China.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Coll Physicians Surg Pak
JT  - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JID - 9606447
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (ICAM1 protein, human)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Chemokine CCL2/*blood
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus
MH  - *Diabetic Retinopathy/complications
MH  - Homocysteine/*blood
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*blood
MH  - *Macular Edema/blood
MH  - *Vision, Low/blood/etiology
EDAT- 2022/01/06 06:00
MHDA- 2022/01/07 06:00
CRDT- 2022/01/05 01:09
PHST- 2021/09/27 00:00 [received]
PHST- 2021/11/19 00:00 [accepted]
PHST- 2022/01/05 01:09 [entrez]
PHST- 2022/01/06 06:00 [pubmed]
PHST- 2022/01/07 06:00 [medline]
AID - 040579197 [pii]
AID - 10.29271/jcpsp.2022.01.57 [doi]
PST - ppublish
SO  - J Coll Physicians Surg Pak. 2022 Jan;32(1):57-60. doi: 10.29271/jcpsp.2022.01.57.