PMID- 34983570
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220108
IS  - 1749-8546 (Print)
IS  - 1749-8546 (Electronic)
IS  - 1749-8546 (Linking)
VI  - 17
IP  - 1
DP  - 2022 Jan 5
TI  - Echinacoside exhibits antidepressant-like effects through AMPAR-Akt/ERK-mTOR 
      pathway stimulation and BDNF expression in mice.
PG  - 9
LID - 10.1186/s13020-021-00549-5 [doi]
LID - 9
AB  - BACKGROUND: Several natural products have been demonstrated to be effective in 
      the treatment of depressive disorders. Echinacoside, a naturally occurring phenol 
      extracted from Cistanche tubulosa, Echinacea angustifolia, and Cistanche spp, has 
      a wide range of physiological effects, such as antioxidation, neuroprotection, 
      anti-inflammatory, and immunoregulation, which are closely related to depression. 
      In addition, echinacoside can activate protein kinase B (Akt), extracellular 
      signal-regulated kinase (ERK), and brain-derived neurotrophic factor (BDNF) in 
      the brain. A key downstream event of the Akt, ERK, and BDNF signaling pathways, 
      namely mechanistic target of rapamycin (mTOR) signaling, plays a crucial role in 
      generating an rapid antidepressant effect. Thus, echinacoside is a promising 
      therapeutic agent for depression. However, research regarding the role of 
      echinacoside in antidepressant effect and brain mTOR activation remains lacking. 
      MATERIALS AND METHODS: The forced swimming test and Western blot analysis in 
      C57BL/6 mice was used to investigate the antidepressant-like activities of 
      echinacoside and the underlying mechanism involved 
      inalpha-amino3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor 
      (AMPAR)-Akt/ERK-mTOR pathway. RESULTS: We confirmed the suggestions by previous 
      reports that echinacoside activates Akt/ERK signaling and further demonstrated 
      that echinacoside could provide antidepressant-like effects in mice via the 
      activation of AMPAR-Akt/ERK-mTOR pathway in the hippocampus. CONCLUSIONS: To the 
      best of our knowledge, our study is the first to reveal that echinacoside is a 
      potential treatment for depressive disorders. Moreover, the present study 
      suggests a mechanism for the neuroprotective effect of echinacoside.
CI  - (c) 2022. The Author(s).
FAU - Chuang, Han-Wen
AU  - Chuang HW
AD  - Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 
      Taiwan.
FAU - Wang, Tse-Yen
AU  - Wang TY
AD  - Department of Post-baccalaureate Chinese Medicine, China Medical University, 
      Taichung, Taiwan.
FAU - Huang, Chih-Chia
AU  - Huang CC
AUID- ORCID: 0000-0001-8703-1878
AD  - Tsaotun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan. 
      chihchiahuang@yahoo.com.tw.
AD  - Department of Psychiatry, China Medical University, Taichung, Taiwan. 
      chihchiahuang@yahoo.com.tw.
AD  - Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan. 
      chihchiahuang@yahoo.com.tw.
AD  - Program in Translational Medicine, National Chung Hsing University, Taichung, 
      Taiwan. chihchiahuang@yahoo.com.tw.
FAU - Wei, I-Hua
AU  - Wei IH
AD  - Department of Anatomy, China Medical University, Taichung, Taiwan. 
      ihwei@mail.cmu.edu.tw.
LA  - eng
GR  - TTPC-110018/Tsaotun Psychiatric Center, Ministry of Health and Welfare, Nantou, 
      Taiwan/
GR  - MOST 106-2314-B-039-029-MY3/ministry of science and technology, Taiwan/
GR  - MOST 109-2314-B-039-040/ministry of science and technology, Taiwan/
GR  - MOST 109-2320-B-039-046/ministry of science and technology, Taiwan/
GR  - MOST 110-2320-B-039-037/ministry of science and technology, Taiwan/
GR  - DMR-108-092 and DMR-109-101/China medical university hospital/
GR  - CMU110-MF-87/China Medical University, Taiwan/
PT  - Journal Article
DEP - 20220105
PL  - England
TA  - Chin Med
JT  - Chinese medicine
JID - 101265109
PMC - PMC8728918
OTO - NOTNLM
OT  - AMPAR
OT  - Akt
OT  - Antidepressant
OT  - ERK
OT  - Echinacoside
OT  - mTOR
COIS- The authors declare that they have no competing interests.
EDAT- 2022/01/06 06:00
MHDA- 2022/01/06 06:01
PMCR- 2022/01/05
CRDT- 2022/01/05 05:41
PHST- 2021/07/29 00:00 [received]
PHST- 2021/12/06 00:00 [accepted]
PHST- 2022/01/05 05:41 [entrez]
PHST- 2022/01/06 06:00 [pubmed]
PHST- 2022/01/06 06:01 [medline]
PHST- 2022/01/05 00:00 [pmc-release]
AID - 10.1186/s13020-021-00549-5 [pii]
AID - 549 [pii]
AID - 10.1186/s13020-021-00549-5 [doi]
PST - epublish
SO  - Chin Med. 2022 Jan 5;17(1):9. doi: 10.1186/s13020-021-00549-5.