PMID- 34984975
OWN - NLM
STAT- MEDLINE
DCOM- 20220302
LR  - 20220302
IS  - 2050-084X (Electronic)
IS  - 2050-084X (Linking)
VI  - 11
DP  - 2022 Jan 5
TI  - The anterior cingulate cortex and its role in controlling contextual fear memory 
      to predatory threats.
LID - 10.7554/eLife.67007 [doi]
LID - e67007
AB  - Predator exposure is a life-threatening experience and elicits learned fear 
      responses to the context in which the predator was encountered. The anterior 
      cingulate area (ACA) occupies a pivotal position in a cortical network responsive 
      to predatory threats, and it exerts a critical role in processing fear memory. 
      The experiments were made in mice and revealed that the ACA is involved in both 
      the acquisition and expression of contextual fear to predatory threat. Overall, 
      the ACA can provide predictive relationships between the context and the predator 
      threat and influences fear memory acquisition through projections to the 
      basolateral amygdala and perirhinal region and the expression of contextual fear 
      through projections to the dorsolateral periaqueductal gray. Our results expand 
      previous studies based on classical fear conditioning and open interesting 
      perspectives for understanding how the ACA is involved in processing contextual 
      fear memory to ethologic threatening conditions that entrain specific medial 
      hypothalamic fear circuits.
CI  - (c) 2022, de Lima et al.
FAU - de Lima, Miguel Antonio Xavier
AU  - de Lima MAX
AD  - Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, 
      Sao Paulo, Brazil.
FAU - Baldo, Marcus Vinicius C
AU  - Baldo MVC
AD  - Department of Physiology and Biophysics, Institute of Biomedical Sciences, 
      University of Sao Paulo, Sao Paulo, Brazil.
FAU - Oliveira, Fernando A
AU  - Oliveira FA
AUID- ORCID: 0000-0002-1632-4267
AD  - Cellular and Molecular Neurobiology Laboratory (LaNeC) - Center for Mathematics, 
      Computing and Cognition (CMCC), Federal University of ABC, Sao Bernardo do Campo, 
      Brazil.
FAU - Canteras, Newton Sabino
AU  - Canteras NS
AUID- ORCID: 0000-0002-7205-5372
AD  - Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, 
      Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220105
PL  - England
TA  - Elife
JT  - eLife
JID - 101579614
SB  - IM
MH  - Animals
MH  - *Behavior, Animal
MH  - Cats
MH  - Cerebral Cortex/physiology
MH  - *Fear
MH  - Female
MH  - Gyrus Cinguli/*physiology
MH  - Male
MH  - *Memory
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neural Pathways/physiology
MH  - *Predatory Behavior
PMC - PMC8730726
OTO - NOTNLM
OT  - cerebral cortex
OT  - defensive behavior
OT  - fear memory
OT  - mouse
OT  - neuroscience
COIS- Md, MB, FO, NC No competing interests declared
EDAT- 2022/01/06 06:00
MHDA- 2022/03/03 06:00
PMCR- 2022/01/05
CRDT- 2022/01/05 08:43
PHST- 2021/01/28 00:00 [received]
PHST- 2021/12/13 00:00 [accepted]
PHST- 2022/01/05 08:43 [entrez]
PHST- 2022/01/06 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2022/01/05 00:00 [pmc-release]
AID - 67007 [pii]
AID - 10.7554/eLife.67007 [doi]
PST - epublish
SO  - Elife. 2022 Jan 5;11:e67007. doi: 10.7554/eLife.67007.