PMID- 34986378
OWN - NLM
STAT- MEDLINE
DCOM- 20220307
LR  - 20220307
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 301
DP  - 2022 Mar 15
TI  - Mixtures modeling identifies vitamin B1 and B3 intakes associated with 
      depression.
PG  - 68-80
LID - S0165-0327(21)01450-6 [pii]
LID - 10.1016/j.jad.2021.12.133 [doi]
AB  - BACKGROUND: We aim to identify the association between a mixture of vitamin B1, 
      B2, and B3 intakes and depression. METHODS: Daily intake of vitamins was measured 
      by a one-day 24 h recall. Multivariate logistic regression, weighted quantile sum 
      (WQS), quantile g-computation (qgcomp), and Bayesian kernel machine regression 
      (BKMR) were used. RESULTS: Of 9,848 adults included in the final analysis, 4.38% 
      had depression. In the logistic regression model, daily vitamin B1 and B3 intakes 
      were associated with depression, and significant trends were observed for these 
      vitamin intake tertiles (p < 0.001). The WQS index was significantly associated 
      with depression (OR = 0.24, 95% CI: 0.23-0.24). The gqcomp index also found a 
      significant association between a mixture of vitamin B1 and B3 intake and 
      depression (OR = 0.67, 95% CI: 0.44-0.98). Vitamin B1 intake was the most heavily 
      weighed vitamin intake in this model. In BKMR analysis, the overall effects of 
      vitamin B1 and B3 intake mixture were negatively associated with depression. 
      Vitamin B1 and B3 intake showed negative trends and was observed as the most 
      important factor associated with depression. The cutoff levels for B vitamin 
      intake levels related to depression were reported. LIMITATIONS: A 24-hour recall 
      and cross-sectional design were used. CONCLUSIONS: Given the rising prevalence of 
      depressive symptoms in Korea, an increase in daily intake of vitamin B1 and/or B3 
      through regular diets may help to reduce the risk of depression. Therefore, there 
      is an ongoing need to investigate these associations between B vitamin 
      supplementation and depression, either separately or jointly, in 
      well-characterized cohorts of depression population.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Nguyen, Hai Duc
AU  - Nguyen HD
AD  - Department of Pharmacy, College of Pharmacy and Research Institute of Life and 
      Pharmaceutical Sciences, Sunchon National University, Sunchon, Jeonnam 57922, 
      Republic of Korea.
FAU - Oh, Hojin
AU  - Oh H
AD  - Department of Pharmacy, College of Pharmacy and Research Institute of Life and 
      Pharmaceutical Sciences, Sunchon National University, Sunchon, Jeonnam 57922, 
      Republic of Korea.
FAU - Kim, Min-Sun
AU  - Kim MS
AD  - Department of Pharmacy, College of Pharmacy and Research Institute of Life and 
      Pharmaceutical Sciences, Sunchon National University, Sunchon, Jeonnam 57922, 
      Republic of Korea. Electronic address: minsun@scnu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220102
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Vitamins)
RN  - P6YC3EG204 (Vitamin B 12)
RN  - X66NSO3N35 (Thiamine)
SB  - IM
MH  - Adult
MH  - Bayes Theorem
MH  - Cross-Sectional Studies
MH  - *Depression/epidemiology
MH  - Humans
MH  - *Thiamine
MH  - Vitamin B 12
MH  - Vitamins
OTO - NOTNLM
OT  - Depression
OT  - Mixture of vitamin intakes
OT  - Vitamin B1
OT  - Vitamin B3
EDAT- 2022/01/06 06:00
MHDA- 2022/03/08 06:00
CRDT- 2022/01/05 20:06
PHST- 2021/08/18 00:00 [received]
PHST- 2021/12/28 00:00 [revised]
PHST- 2021/12/31 00:00 [accepted]
PHST- 2022/01/06 06:00 [pubmed]
PHST- 2022/03/08 06:00 [medline]
PHST- 2022/01/05 20:06 [entrez]
AID - S0165-0327(21)01450-6 [pii]
AID - 10.1016/j.jad.2021.12.133 [doi]
PST - ppublish
SO  - J Affect Disord. 2022 Mar 15;301:68-80. doi: 10.1016/j.jad.2021.12.133. Epub 2022 
      Jan 2.