PMID- 34987576
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220429
IS  - 1687-8337 (Print)
IS  - 1687-8345 (Electronic)
IS  - 1687-8337 (Linking)
VI  - 2021
DP  - 2021
TI  - Gestational Diabetes Mellitus: Clinical Characteristics and Perinatal Outcomes in 
      a Multiethnic Population of North Italy.
PG  - 9474805
LID - 10.1155/2021/9474805 [doi]
LID - 9474805
AB  - AIM: To evaluate clinical characteristics and perinatal outcomes in a 
      heterogeneous population of Caucasians born in Italy and High Migration Pressure 
      Countries (HMPC) women with GDM living in Piedmont, North Italy. METHODS: We 
      retrospectively analyzed data from 586 women referring to our unit (2015-2020). 
      Epidemiological (age and country of origin) and clinical-metabolic features 
      (height, weight, family history of DM, parity, previous history of GDM, OGTT 
      results, and GDM treatment) were collected. The database of certificates of care 
      at delivery was consulted in relation to neonatal/maternal complications (rates 
      of caesarean sections, APGAR score, fetal malformations, and neonatal 
      anthropometry). RESULTS: 43.2% of women came from HMPC; they were younger (p < 
      0.0001) and required insulin treatment more frequently than Caucasian women born 
      in Italy (chi (2) = 17.8, p=0.007). Higher fasting and 120-minute OGTT levels and 
      gestational BMI increased the risk of insulin treatment (OGTT T0: OR = 1.04, CI 
      95% 1.016-1.060, p=0.005; OGTT T120: OR = 1.01, CI 95% 1.002-1.020, p=0.02; BMI: 
      OR = 1.089, CI 95% 1.051-1.129, p < 0.0001). Moreover, two or more diagnostic 
      OGTT glucose levels doubled the risk of insulin therapy (OR = 2.03, IC 95% 
      1.145-3.612, p=0.016). We did not find any association between ethnicities and 
      neonatal/maternal complications. CONCLUSIONS: In our multiethnic GDM population, 
      the need for intensive care and insulin treatment is high in HPMC women although 
      the frequency of adverse peripartum and newborn outcomes does not vary among 
      ethnic groups. The need for insulin therapy should be related to different 
      genetic backgrounds, dietary habits, and Nutrition Transition phenomena. Thus, 
      nutritional intervention and insulin treatment need to be tailored.
CI  - Copyright (c) 2021 M. Caputo et al.
FAU - Caputo, M
AU  - Caputo M
AUID- ORCID: 0000-0003-0470-9343
AD  - Endocrinology, Department of Translational Medicine, Universita del Piemonte 
      Orientale, Novara, Italy.
AD  - Department of Health Sciences, Universita del Piemonte Orientale, Novara, Italy.
FAU - Bullara, V
AU  - Bullara V
AD  - SCDU Endocrinologia, AOU "Maggiore della Carita" Novara, Novara, Italy.
FAU - Mele, C
AU  - Mele C
AD  - Endocrinology, Department of Translational Medicine, Universita del Piemonte 
      Orientale, Novara, Italy.
FAU - Sama, M T
AU  - Sama MT
AD  - SCDU Endocrinologia, AOU "Maggiore della Carita" Novara, Novara, Italy.
FAU - Zavattaro, M
AU  - Zavattaro M
AD  - SCDU Endocrinologia, AOU "Maggiore della Carita" Novara, Novara, Italy.
FAU - Ferrero, A
AU  - Ferrero A
AD  - Endocrinology, Department of Translational Medicine, Universita del Piemonte 
      Orientale, Novara, Italy.
FAU - Daffara, T
AU  - Daffara T
AD  - Endocrinology, Department of Translational Medicine, Universita del Piemonte 
      Orientale, Novara, Italy.
FAU - Leone, I
AU  - Leone I
AD  - Endocrinology, Department of Translational Medicine, Universita del Piemonte 
      Orientale, Novara, Italy.
FAU - Giachetti, G
AU  - Giachetti G
AD  - Endocrinology, Department of Translational Medicine, Universita del Piemonte 
      Orientale, Novara, Italy.
FAU - Antoniotti, V
AU  - Antoniotti V
AD  - Department of Health Sciences, Universita del Piemonte Orientale, Novara, Italy.
FAU - Longo, D
AU  - Longo D
AD  - Gynecology and Obstetrics, Department of Translational Medicine, Universita del 
      Piemonte Orientale, Novara, Italy.
FAU - De Pedrini, A
AU  - De Pedrini A
AD  - Gynecology and Obstetrics, Department of Translational Medicine, Universita del 
      Piemonte Orientale, Novara, Italy.
FAU - Marzullo, P
AU  - Marzullo P
AD  - Endocrinology, Department of Translational Medicine, Universita del Piemonte 
      Orientale, Novara, Italy.
AD  - IRCCS Istituto Auxologico Italiano, Laboratory of Metabolic Research, Novara, 
      Italy.
FAU - Remorgida, V
AU  - Remorgida V
AD  - Gynecology and Obstetrics, Department of Translational Medicine, Universita del 
      Piemonte Orientale, Novara, Italy.
FAU - Prodam, F
AU  - Prodam F
AUID- ORCID: 0000-0001-9660-5335
AD  - Endocrinology, Department of Translational Medicine, Universita del Piemonte 
      Orientale, Novara, Italy.
AD  - Department of Health Sciences, Universita del Piemonte Orientale, Novara, Italy.
FAU - Aimaretti, G
AU  - Aimaretti G
AD  - Endocrinology, Department of Translational Medicine, Universita del Piemonte 
      Orientale, Novara, Italy.
LA  - eng
PT  - Journal Article
DEP - 20211226
PL  - Egypt
TA  - Int J Endocrinol
JT  - International journal of endocrinology
JID - 101516376
PMC - PMC8720593
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/01/07 06:00
MHDA- 2022/01/07 06:01
PMCR- 2021/12/26
CRDT- 2022/01/06 05:54
PHST- 2021/11/01 00:00 [received]
PHST- 2021/12/14 00:00 [accepted]
PHST- 2022/01/06 05:54 [entrez]
PHST- 2022/01/07 06:00 [pubmed]
PHST- 2022/01/07 06:01 [medline]
PHST- 2021/12/26 00:00 [pmc-release]
AID - 10.1155/2021/9474805 [doi]
PST - epublish
SO  - Int J Endocrinol. 2021 Dec 26;2021:9474805. doi: 10.1155/2021/9474805. 
      eCollection 2021.