PMID- 34988228
OWN - NLM
STAT- MEDLINE
DCOM- 20220328
LR  - 20220328
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2021
DP  - 2021
TI  - Potential Role of Natural Plant Medicine Cyclocarya paliurus in the Treatment of 
      Type 2 Diabetes Mellitus.
PG  - 1655336
LID - 10.1155/2021/1655336 [doi]
LID - 1655336
AB  - Type 2 diabetes mellitus (T2DM) is a common chronic metabolic disease that has 
      become increasingly prevalent worldwide. It poses a serious threat to human 
      health and places a considerable burden on global social medical work. To meet 
      the increasing demand for T2DM treatment, research on hypoglycemic drugs is 
      rapidly developing. Cyclocarya paliurus (Batal.) Iljinskaja is a medicinal plant 
      that grows in China. The leaves of C. paliurus contain polysaccharides, 
      triterpenoids, and other chemical components, which have numerous health 
      benefits. Therefore, the use of this plant has attracted extensive attention in 
      the medical community. Over the past few decades, contemporary pharmacological 
      studies on C. paliurus extracts have revealed that it has abundant biological 
      activities. Multiple in vitro and in vivo experiments have shown that C. paliurus 
      extracts are safe and can play a therapeutic role in T2DM through 
      anti-inflammatory and antioxidation activities, and intestinal flora regulation. 
      Its efficacy is closely related to many factors, such as extraction, separation, 
      purification, and modification. Based on summarizing the existing extraction 
      methods, this article further reviews the potential mechanism of C. paliurus 
      extracts in T2DM treatment, and we aimed to provide a reference for future 
      research on natural plant medicine for the prevention and treatment of T2DM and 
      its related complications.
CI  - Copyright (c) 2021 Han Wang et al.
FAU - Wang, Han
AU  - Wang H
AUID- ORCID: 0000-0003-1247-9859
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, China.
FAU - Tang, Cheng
AU  - Tang C
AUID- ORCID: 0000-0003-1047-2805
AD  - Changchun University of Chinese Medicine, China.
FAU - Gao, Zezheng
AU  - Gao Z
AUID- ORCID: 0000-0002-4125-5435
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, China.
FAU - Huang, Yishan
AU  - Huang Y
AUID- ORCID: 0000-0003-0115-7694
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, China.
FAU - Zhang, Boxun
AU  - Zhang B
AUID- ORCID: 0000-0001-6748-4044
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, China.
FAU - Wei, Jiahua
AU  - Wei J
AUID- ORCID: 0000-0002-8607-2368
AD  - Changchun University of Chinese Medicine, China.
FAU - Zhao, Linhua
AU  - Zhao L
AUID- ORCID: 0000-0002-0362-7365
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, China.
FAU - Tong, Xiaolin
AU  - Tong X
AUID- ORCID: 0000-0002-9873-4154
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211227
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Antioxidants/metabolism/pharmacology/therapeutic use
MH  - Diabetes Mellitus, Type 2/diagnosis/*metabolism
MH  - Humans
MH  - Juglandaceae/*metabolism
MH  - Oxidative Stress/drug effects
MH  - Plant Extracts/metabolism/pharmacology/*therapeutic use
PMC - PMC8723876
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/01/07 06:00
MHDA- 2022/03/29 06:00
PMCR- 2021/12/27
CRDT- 2022/01/06 06:00
PHST- 2021/08/05 00:00 [received]
PHST- 2021/10/11 00:00 [revised]
PHST- 2021/11/19 00:00 [accepted]
PHST- 2022/01/06 06:00 [entrez]
PHST- 2022/01/07 06:00 [pubmed]
PHST- 2022/03/29 06:00 [medline]
PHST- 2021/12/27 00:00 [pmc-release]
AID - 10.1155/2021/1655336 [doi]
PST - epublish
SO  - J Diabetes Res. 2021 Dec 27;2021:1655336. doi: 10.1155/2021/1655336. eCollection 
      2021.