PMID- 34988804
OWN - NLM
STAT- MEDLINE
DCOM- 20220412
LR  - 20220412
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 19
DP  - 2022 Apr
TI  - Influence of combined exposure levels of total arsenic and inorganic arsenic on 
      arsenic methylation capacity among university students: findings from Bayesian 
      kernel machine regression analysis.
PG  - 28714-28724
LID - 10.1007/s11356-021-17906-4 [doi]
AB  - The arsenic (As) methylation capacity is an important determinant of 
      susceptibility to As-related diseases. Total As (TAs) or inorganic As (iAs) was 
      reported to associated with As methylation capacity. We measured urinary 
      concentrations of iAs, monomethylarsonic acid (MMA), and dimethylarsinic acid 
      (DMA) by using HPLC-HG-AFS and calculated the primary methylation capacity index 
      (PMI) and secondary methylation capacity index (SMI) in 209 university students 
      in Hefei, China, a non-As endemic area. Volunteers were given a standardized 
      questionnaire asking about their sociodemographic characteristics. Bayesian 
      kernel machine regression (BKMR) analysis was used to estimate the association of 
      lnTAs and lniAs levels with methylation indices (ln%MMA, ln%DMA, lnPMI, lnSMI). 
      The median concentrations of iAs, MMA, and DMA were 1.22, 0.92, and 12.17 mug/L, 
      respectively; the proportions of iAs, MMA, and DMA were 8.76%, 6.13%, and 84.84%, 
      respectively. Females had higher %DMA and lower %MMA than males. The combined 
      levels of lnTAs and lniAs showed a decrease in the changes in ln%DMA and lnSMI. 
      With regard to the single exposure level, the lnTAs showed positive correlations 
      with ln%DMA, lnPMI, and lnSMI when lniAs was set at a specific level, while lniAs 
      showed negative correlations with ln%DMA, lnPMI, and lnSMI when lnTAs was set at 
      a specific level; all the dose-response relationships were nonlinear. Our results 
      suggested that combined levels of TAs and iAs play an important role in reducing 
      As methylation capacity, especially iAs, and the reduction only occurs when TAs 
      and iAs are present up to a certain combined level.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Jiang, Rui
AU  - Jiang R
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Zhang, Qing
AU  - Zhang Q
AD  - Department of Ophthalmology, The Second Hospital of Anhui Medical University, No 
      678 Furong Road, Hefei, 230601, Anhui, China.
FAU - Ji, Dongmei
AU  - Ji D
AD  - NHC Key Laboratory of Study On Abnormal Gametes and Reproductive Tract, No 81 
      Meishan Road, Hefei, 230032, Anhui, China.
FAU - Jiang, Tingting
AU  - Jiang T
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Hu, Yuan
AU  - Hu Y
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - He, Shitao
AU  - He S
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Tao, Long
AU  - Tao L
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Shen, Juan
AU  - Shen J
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Song, Yuxiang
AU  - Song Y
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Ma, Yicheng
AU  - Ma Y
AD  - The Second Clinical Medical College, Anhui Medical University, No 678 Furong 
      Road, Hefei, 230601, Anhui, China.
FAU - Tong, Shilu
AU  - Tong S
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China.
AD  - Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
AD  - School of Public Health and Social Work and Institute of Health and Biomedical 
      Innovation, Queensland University of Technology, Brisbane, Australia.
FAU - Tao, Fangbiao
AU  - Tao F
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China. fbtao@ahmu.edu.cn.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China. fbtao@ahmu.edu.cn.
AD  - Anhui Provincial Key Laboratory of Population Health and Aristogenics/Key 
      Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, 
      Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China. 
      fbtao@ahmu.edu.cn.
FAU - Yao, Yuyou
AU  - Yao Y
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China. yaoanqi71@aliyun.com.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China. yaoanqi71@aliyun.com.
AD  - Anhui Provincial Key Laboratory of Population Health and Aristogenics/Key 
      Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, 
      Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China. 
      yaoanqi71@aliyun.com.
FAU - Liang, Chunmei
AU  - Liang C
AUID- ORCID: 0000-0003-1639-7543
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China. liang_chun_mei@126.com.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China. liang_chun_mei@126.com.
AD  - Anhui Provincial Key Laboratory of Population Health and Aristogenics/Key 
      Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, 
      Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China. 
      liang_chun_mei@126.com.
LA  - eng
PT  - Journal Article
DEP - 20220106
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Arsenicals)
RN  - AJ2HL7EU8K (Cacodylic Acid)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - *Arsenic/analysis
MH  - *Arsenicals
MH  - Bayes Theorem
MH  - Cacodylic Acid
MH  - Environmental Exposure
MH  - Female
MH  - Humans
MH  - Male
MH  - Methylation
MH  - Regression Analysis
MH  - Students
MH  - Universities
OTO - NOTNLM
OT  - Arsenic
OT  - Bayesian kernel machine regression
OT  - HPLC-HG-AFS
OT  - Influencing factors
OT  - Methylation capacity
OT  - Urine
EDAT- 2022/01/07 06:00
MHDA- 2022/04/13 06:00
CRDT- 2022/01/06 06:14
PHST- 2021/09/10 00:00 [received]
PHST- 2021/11/29 00:00 [accepted]
PHST- 2022/01/07 06:00 [pubmed]
PHST- 2022/04/13 06:00 [medline]
PHST- 2022/01/06 06:14 [entrez]
AID - 10.1007/s11356-021-17906-4 [pii]
AID - 10.1007/s11356-021-17906-4 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 Apr;29(19):28714-28724. doi: 
      10.1007/s11356-021-17906-4. Epub 2022 Jan 6.