PMID- 34988858
OWN - NLM
STAT- MEDLINE
DCOM- 20221121
LR  - 20221121
IS  - 1863-4362 (Electronic)
IS  - 0021-1265 (Linking)
VI  - 191
IP  - 6
DP  - 2022 Dec
TI  - Maternal mortality due to valvular heart disease: a population-based study in 
      Turkey.
PG  - 2531-2537
LID - 10.1007/s11845-021-02879-7 [doi]
AB  - BACKGROUND/AIM: To assess the clinical and demographic features of maternal 
      mortality cases among patients with cardiac valvular diseases between 2012 and 
      2019. METHODS: Maternal mortality due to valvular heart disease between January 
      2012 and December 2019 in Turkey was retrospectively analyzed. The cases were 
      classified according to New York Heart Association (NYHA) classification based on 
      the severity of the heart disease. NYHA classification groups were divided into 
      two; as class I-II (n = 34) and class III-IV (n = 31). Two groups were compared 
      in terms of demographic and clinical characteristics. RESULTS: Valvular heart 
      disease was diagnosed in 41 (63.1%) of the cases before pregnancy. It was found 
      that 100% (n = 21) of the warfarin users had switched to low molecular weight 
      heparin treatment due to concerns about warfarin embryopathy after the diagnosis 
      of pregnancy, and only 14.2% (n = 3) of them had been monitorized with Antifactor 
      Xa activity to evaluate the effectiveness of the medication. Two NYHA groups had 
      similar clinical characteristics. Intensive care unit admission rate, frequency 
      of prosthetic valve, rate of thromboprophylaxis, type of valvular disease and 
      reasons of maternal death were similar between the NYHA groups (p < 0.05). 
      CONCLUSION: Maternal mortality may be observed in cases with NYHA class I-II in 
      almost similar rates with NYHA class III-IV. Therefore, it is crucial to 
      adequately assess the mortality risk of pregnant women with cardiac valvular 
      pathologies and to achieve early diagnosis and appropriate treatment in order to 
      reduce maternal mortality.
CI  - (c) 2021. The Author(s), under exclusive licence to Royal Academy of Medicine in 
      Ireland.
FAU - Yucel, Aykan
AU  - Yucel A
AUID- ORCID: 0000-0002-5888-692X
AD  - Preliminary Investigation Committee for Maternal Deaths, Turkish Public Health 
      Agency, Turkish Ministry of Health, Ankara, Turkey.
AD  - Department of Obstetrics and Gynecology, University of Health Sciences, Turkish 
      Ministry of Health Ankara City Hospital, Ankara, Turkey.
FAU - Koksal, Zuhal
AU  - Koksal Z
AUID- ORCID: 0000-0002-3562-9859
AD  - Preliminary Investigation Committee for Maternal Deaths, Turkish Public Health 
      Agency, Turkish Ministry of Health, Ankara, Turkey.
FAU - Ensari, Tugba
AU  - Ensari T
AUID- ORCID: 0000-0002-7819-5325
AD  - Preliminary Investigation Committee for Maternal Deaths, Turkish Public Health 
      Agency, Turkish Ministry of Health, Ankara, Turkey.
FAU - Tanacan, Atakan
AU  - Tanacan A
AUID- ORCID: 0000-0001-8209-8248
AD  - Preliminary Investigation Committee for Maternal Deaths, Turkish Public Health 
      Agency, Turkish Ministry of Health, Ankara, Turkey.
FAU - Altinboga, Orhan
AU  - Altinboga O
AUID- ORCID: 0000-0001-9992-8535
AD  - Preliminary Investigation Committee for Maternal Deaths, Turkish Public Health 
      Agency, Turkish Ministry of Health, Ankara, Turkey.
FAU - Baydilli, Meltem Buz
AU  - Baydilli MB
AUID- ORCID: 0000-0003-0321-4752
AD  - Preliminary Investigation Committee for Maternal Deaths, Turkish Public Health 
      Agency, Turkish Ministry of Health, Ankara, Turkey.
FAU - Esen, Meral
AU  - Esen M
AUID- ORCID: 0000-0002-7657-6458
AD  - Preliminary Investigation Committee for Maternal Deaths, Turkish Public Health 
      Agency, Turkish Ministry of Health, Ankara, Turkey.
FAU - Karabacak, Yurdum
AU  - Karabacak Y
AUID- ORCID: 0000-0002-5831-3048
AD  - Preliminary Investigation Committee for Maternal Deaths, Turkish Public Health 
      Agency, Turkish Ministry of Health, Ankara, Turkey.
FAU - Ongun, Veli Dundar
AU  - Ongun VD
AUID- ORCID: 0000-0003-1947-9448
AD  - Preliminary Investigation Committee for Maternal Deaths, Turkish Public Health 
      Agency, Turkish Ministry of Health, Ankara, Turkey.
FAU - Sahlar, Tuba Esra
AU  - Sahlar TE
AUID- ORCID: 0000-0002-9566-8825
AD  - Preliminary Investigation Committee for Maternal Deaths, Turkish Public Health 
      Agency, Turkish Ministry of Health, Ankara, Turkey.
FAU - Keskinkilic, Bekir
AU  - Keskinkilic B
AUID- ORCID: 0000-0002-4626-1789
AD  - Preliminary Investigation Committee for Maternal Deaths, Turkish Public Health 
      Agency, Turkish Ministry of Health, Ankara, Turkey.
FAU - Kara, Fatih
AU  - Kara F
AUID- ORCID: 0000-0002-4106-3716
AD  - Preliminary Investigation Committee for Maternal Deaths, Turkish Public Health 
      Agency, Turkish Ministry of Health, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220106
PL  - Ireland
TA  - Ir J Med Sci
JT  - Irish journal of medical science
JID - 7806864
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Pregnancy
MH  - Humans
MH  - Female
MH  - Maternal Mortality
MH  - Retrospective Studies
MH  - Anticoagulants/adverse effects
MH  - Turkey/epidemiology
MH  - *Venous Thromboembolism
MH  - *Heart Valve Diseases
OTO - NOTNLM
OT  - Maternal mortality
OT  - New York Heart Association Classification
OT  - Pregnancy
OT  - Valvular heart disease
EDAT- 2022/01/07 06:00
MHDA- 2022/11/22 06:00
CRDT- 2022/01/06 06:15
PHST- 2021/06/23 00:00 [received]
PHST- 2021/11/30 00:00 [accepted]
PHST- 2022/01/07 06:00 [pubmed]
PHST- 2022/11/22 06:00 [medline]
PHST- 2022/01/06 06:15 [entrez]
AID - 10.1007/s11845-021-02879-7 [pii]
AID - 10.1007/s11845-021-02879-7 [doi]
PST - ppublish
SO  - Ir J Med Sci. 2022 Dec;191(6):2531-2537. doi: 10.1007/s11845-021-02879-7. Epub 
      2022 Jan 6.