PMID- 3498916
OWN - NLM
STAT- MEDLINE
DCOM- 19871118
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 80
IP  - 1
DP  - 1987 Sep 11
TI  - Central hypothermic effects of some analogues of 
      1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 
      1-methyl-4-phenylpyridinium ion (MPP+).
PG  - 100-5
AB  - Effects of some MPTP or MPP+ analogues on mouse body temperature were studied. Of 
      the analogues tested, 4-phenylpyridine (PPY) and 
      4-phenyl-1,2,3,6-tetrahydropyridine (PTP) given in single i.p. doses to mice 
      caused marked hypothermia. Intracerebroventricular (i.c.v.) injection of PPY or 
      PTP caused similar hypothermia. Pretreatment with clorgyline or (-)-deprenyl 
      greatly prevented hypothermia induced by i.c.v. PPY, but hypothermia by i.c.v. 
      PTP was prevented only by (-)-deprenyl. These results indicate that, in order to 
      cause central hypothermia, PTP does not seem to require metabolism to PPY and 
      both analogues per se may cause hypothermia.
FAU - Satoh, N
AU  - Satoh N
AD  - Department of Pharmacology, Tohoku College of Pharmacy, Sendai, Japan.
FAU - Yonezawa, A
AU  - Yonezawa A
FAU - Tadano, T
AU  - Tadano T
FAU - Kisara, K
AU  - Kisara K
FAU - Arai, Y
AU  - Arai Y
FAU - Kinemuchi, H
AU  - Kinemuchi H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Pyridines)
RN  - 0 (Pyridinium Compounds)
RN  - 9P21XSP91P (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
RN  - R865A5OY8J (1-Methyl-4-phenylpyridinium)
SB  - IM
MH  - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
MH  - 1-Methyl-4-phenylpyridinium
MH  - Animals
MH  - Body Temperature Regulation/*drug effects
MH  - Central Nervous System/*drug effects
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Pyridines/administration & dosage/*pharmacology
MH  - Pyridinium Compounds/administration & dosage/*pharmacology
EDAT- 1987/09/11 00:00
MHDA- 1987/09/11 00:01
CRDT- 1987/09/11 00:00
PHST- 1987/09/11 00:00 [pubmed]
PHST- 1987/09/11 00:01 [medline]
PHST- 1987/09/11 00:00 [entrez]
AID - 0304-3940(87)90503-9 [pii]
AID - 10.1016/0304-3940(87)90503-9 [doi]
PST - ppublish
SO  - Neurosci Lett. 1987 Sep 11;80(1):100-5. doi: 10.1016/0304-3940(87)90503-9.