PMID- 34990730
OWN - NLM
STAT- MEDLINE
DCOM- 20220316
LR  - 20220316
IS  - 1872-9754 (Electronic)
IS  - 0197-0186 (Linking)
VI  - 153
DP  - 2022 Feb
TI  - MDMA related neuro-inflammation and adenosine receptors.
PG  - 105275
LID - S0197-0186(21)00321-1 [pii]
LID - 10.1016/j.neuint.2021.105275 [doi]
AB  - 3,4-methylenedioxymethamphetamine (MDMA) is a world-wide abused psychostimulant, 
      which has the neurotoxic effects on dopaminergic and serotonergic neurons in both 
      rodents and non-human primates. Adenosine acts as a neurotransmitter in the brain 
      through the activation of four specific G-protein-coupled receptors and it acts 
      as a neuromodulator of dopamine neurotransmission. Recent studies suggest that 
      stimulation of adenosine receptors oppose many behavioral effects of 
      methamphetamines. This review summarizes the specific cellular mechanisms 
      involved in MDMA neuroinflammatory effects, along with the protective effects of 
      adenosine receptors.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Kermanian, Fatemeh
AU  - Kermanian F
AD  - Department of Anatomy, Faculty of Medicine, Alborz University of Medical 
      Sciences, Karaj, Iran.
FAU - Seghatoleslam, Masoumeh
AU  - Seghatoleslam M
AD  - Evaluative Clinical Sciences, Sunnybrook Research Institute, University of 
      Toronto, ON, Canada.
FAU - Mahakizadeh, Simin
AU  - Mahakizadeh S
AD  - Department of Anatomy, Faculty of Medicine, Alborz University of Medical 
      Sciences, Karaj, Iran. Electronic address: s.mahakizadeh@abzums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220103
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Receptors, Purinergic P1)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Brain
MH  - *Central Nervous System Stimulants/pharmacology
MH  - Dopamine/pharmacology
MH  - Inflammation/chemically induced
MH  - *N-Methyl-3,4-methylenedioxyamphetamine/toxicity
MH  - Receptors, Purinergic P1
OTO - NOTNLM
OT  - Adenosine receptors
OT  - Ecstasy
OT  - MDMA
OT  - Neuroinflammation
EDAT- 2022/01/07 06:00
MHDA- 2022/03/17 06:00
CRDT- 2022/01/06 20:14
PHST- 2021/08/10 00:00 [received]
PHST- 2021/12/25 00:00 [revised]
PHST- 2021/12/30 00:00 [accepted]
PHST- 2022/01/07 06:00 [pubmed]
PHST- 2022/03/17 06:00 [medline]
PHST- 2022/01/06 20:14 [entrez]
AID - S0197-0186(21)00321-1 [pii]
AID - 10.1016/j.neuint.2021.105275 [doi]
PST - ppublish
SO  - Neurochem Int. 2022 Feb;153:105275. doi: 10.1016/j.neuint.2021.105275. Epub 2022 
      Jan 3.