PMID- 34990742
OWN - NLM
STAT- MEDLINE
DCOM- 20220208
LR  - 20220208
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 614
DP  - 2022 Feb 25
TI  - Skin interaction, permeation, and toxicity of silica nanoparticles: Challenges 
      and recent therapeutic and cosmetic advances.
PG  - 121439
LID - S0378-5173(21)01245-X [pii]
LID - 10.1016/j.ijpharm.2021.121439 [doi]
AB  - Silica nanoparticles (SNPs) received more attention with the emergence of 
      nanotechnology with the aim and promise of becoming innovative drug delivery 
      systems. They have been fulfilling this objective with excellence and nowadays 
      they play a central role in biomedical applications. New SNPs application routes 
      are being explored such as the epidermal, dermal, and transdermal routes. With 
      that, novel models of synthesis, functionalization, and applications constantly 
      appear. However, it is essential that such innovations are accompanied by 
      in-depth studies on permeation, biodistribution, metabolization, and elimination 
      of the generated by-products. Such studies are still incipient, if not rare. This 
      article reviews significant findings on SNPs and their skin interactions. An 
      extensive literature review on SNPs synthesis and functionalization methodologies 
      was performed, as well as on the skin characteristics, skin permeation 
      mechanisms, and in vivo toxicity assessments. Furthermore, studies of the past 
      5 years on the main therapeutic and cosmetic products employing SNPs, with 
      greater emphasis on in vivo and ex vivo studies were included.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Morais, Renata Pinho
AU  - Morais RP
AD  - Department of Mechanical Engineering, Universidade Federal do Parana, Curitiba, 
      Brazil. Electronic address: renata.morais@ufpr.br.
FAU - Hochheim, Sabrina
AU  - Hochheim S
AD  - Department of Chemistry, Universidade Federal do Parana, Curitiba, Brazil. 
      Electronic address: sabrina.hochheim@ufpr.br.
FAU - de Oliveira, Carolina C
AU  - de Oliveira CC
AD  - Department of Cell Biology, Universidade Federal do Parana, Curitiba, Brazil. 
      Electronic address: krokoli@ufpr.br.
FAU - Riegel-Vidotti, Izabel C
AU  - Riegel-Vidotti IC
AD  - Department of Chemistry, Universidade Federal do Parana, Curitiba, Brazil. 
      Electronic address: izabel.riegel@ufpr.br.
FAU - Marino, Claudia E B
AU  - Marino CEB
AD  - Department of Mechanical Engineering, Universidade Federal do Parana, Curitiba, 
      Brazil. Electronic address: claudiamarino@ufpr.br.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220103
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Administration, Cutaneous
MH  - Drug Delivery Systems
MH  - *Nanoparticles/toxicity
MH  - *Silicon Dioxide/metabolism/toxicity
MH  - Skin/metabolism
MH  - Tissue Distribution
OTO - NOTNLM
OT  - Silica nanoparticles
OT  - Skin permeation
OT  - Skin toxicity
OT  - Topical drug delivery
OT  - Topical formulations
EDAT- 2022/01/07 06:00
MHDA- 2022/02/09 06:00
CRDT- 2022/01/06 20:14
PHST- 2021/09/23 00:00 [received]
PHST- 2021/12/16 00:00 [revised]
PHST- 2021/12/28 00:00 [accepted]
PHST- 2022/01/07 06:00 [pubmed]
PHST- 2022/02/09 06:00 [medline]
PHST- 2022/01/06 20:14 [entrez]
AID - S0378-5173(21)01245-X [pii]
AID - 10.1016/j.ijpharm.2021.121439 [doi]
PST - ppublish
SO  - Int J Pharm. 2022 Feb 25;614:121439. doi: 10.1016/j.ijpharm.2021.121439. Epub 
      2022 Jan 3.