PMID- 34991564
OWN - NLM
STAT- MEDLINE
DCOM- 20220328
LR  - 20220328
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Jan 6
TI  - Clinical and biological risk factors associated with inflammation in patients 
      with type 2 diabetes mellitus.
PG  - 16
LID - 10.1186/s12902-021-00925-0 [doi]
LID - 16
AB  - BACKGROUND: Chronic inflammation has been associated with insulin resistance and 
      related metabolic dysregulation, including type 2 diabetes mellitus (T2DM). 
      Several non modifiable (i.e. genetic predisposition) and modifiable (i.e. 
      sedentary lifestyle, energy-dense food) risk factors were suggested to explain 
      the mechanisms involved in the development of inflammation, but are difficult to 
      assess in clinical routine. The present study aimed to identify easy to asses 
      clinical and biological risk factors associated with inflammation in patients 
      with T2DM. METHODS: One hundred nine patients (51 men, 58 women), 28-60 years 
      old, from seven primary healthcare centers in Gaza City, Palestine, took part to 
      the cross-sectional study (November 2013-May 2014). Study participants had T2DM 
      with no history of inflammatory diseases, cardiovascular diseases, medication 
      and/or any health condition that might affect the inflammatory markers, 
      interleukin 6 (IL-6) and C-reactive protein (CRP). Inflammation was defined for 
      IL-6 >/= 2 pg/mL and CRP >/= 6 mg/L. Multivariable logistic regressions were used to 
      identify the relationship between inflammation and clinical and biological risk 
      factors. RESULTS: After adjustment for age and gender, inflammation seems to 
      increase with increased body mass index (BMI) (OR: 1.427 [1.055-1.931]), 
      increased fasting blood glucose (OR: 1.029 [1.007-1.052]) and decreased 
      adiponectin values (OR: 0.571 [0.361-0.903]). There were also significant 
      relationships between inflammation and BMI (OR: 1.432 [1.042-1.968]), fasting 
      blood glucose (OR: 1.029 [1.006-1.052]) and adiponectin (OR: 0.569 
      [0.359-0.902]), after adjustment for smoking habits and physical activity. 
      CONCLUSION: Managing obesity and associated complications (i.e. hyperglycemia, 
      high adiponectin levels) might help decreasing inflammation in individuals with 
      T2DM.
CI  - (c) 2022. The Author(s).
FAU - Ellulu, Mohammed S
AU  - Ellulu MS
AD  - Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Al-Azhar 
      University - Gaza (AUG), Gaza, Palestine.
FAU - Samouda, Hanen
AU  - Samouda H
AUID- ORCID: 0000-0003-3450-4189
AD  - Luxembourg Institute of Health, Population Health Department, L-1445, Strassen, 
      Luxembourg. Hanene.Samouda@lih.lu.
LA  - eng
PT  - Journal Article
DEP - 20220106
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adiponectin/blood
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Inflammation/*blood
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
PMC - PMC8740444
OTO - NOTNLM
OT  - Adiponectin
OT  - Body mass index
OT  - Cardiovascular diseases
OT  - Diabetes
OT  - Inflammation
OT  - Obesity
COIS- The authors declare having no conflict of interest.
EDAT- 2022/01/08 06:00
MHDA- 2022/03/29 06:00
PMCR- 2022/01/06
CRDT- 2022/01/07 05:43
PHST- 2021/03/09 00:00 [received]
PHST- 2021/12/22 00:00 [accepted]
PHST- 2022/01/07 05:43 [entrez]
PHST- 2022/01/08 06:00 [pubmed]
PHST- 2022/03/29 06:00 [medline]
PHST- 2022/01/06 00:00 [pmc-release]
AID - 10.1186/s12902-021-00925-0 [pii]
AID - 925 [pii]
AID - 10.1186/s12902-021-00925-0 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2022 Jan 6;22(1):16. doi: 10.1186/s12902-021-00925-0.