PMID- 34992370
OWN - NLM
STAT- MEDLINE
DCOM- 20220110
LR  - 20220429
IS  - 1178-2013 (Electronic)
IS  - 1176-9114 (Print)
IS  - 1176-9114 (Linking)
VI  - 16
DP  - 2021
TI  - Folic Acid Decorated Zeolitic Imidazolate Framework (ZIF-8) Loaded with Baicalin 
      as a Nano-Drug Delivery System for Breast Cancer Therapy.
PG  - 8337-8352
LID - 10.2147/IJN.S340764 [doi]
AB  - BACKGROUND: Baicalin (BAN) has attracted widespread attention due to its 
      low-toxicity and efficient antitumor activity, but its poor water solubility and 
      low bioavailability severely limit its clinical application. Development of a 
      targeted drug delivery system is a good strategy to improve the antitumor 
      activity of baicalin. METHODS: We prepared a BAN nano-drug delivery system 
      PEG-FA@ZIF-8@BAN with a zeolite imidazole framework-8 (ZIF-8) as a carrier, which 
      can achieve the response of folate receptor (FR). We characterized this system in 
      terms of morphology, particle size, zeta-potential, infrared (IR), ultraviolet 
      (UV), x-ray diffraction (XRD), and Brunel-Emmett-Teller (BET), and examined the 
      in vitro cytotoxicity and cellular uptake properties of PEG-FA@ZIF-8@BAN using 
      MCF-7 cells. Lastly, we established a 4T1 tumor-bearing mouse model and evaluated 
      its in vivo anti-mammary cancer activity. RESULTS: The PEG-FA@ZIF-8@BAN 
      nano-delivery system had good dispersion with a BAN loading efficiency of 41.45 +/- 
      1.43%, hydrated particle size of 176 +/- 8.1 nm, Zeta-potential of -23.83 +/- 1.1 mV, 
      and slow and massive drug release in an acidic environment (pH 5.0), whereas 
      release was 11.03% in a neutral environment (pH 7.4). In vitro studies showed 
      that PEG-FA@ZIF-8@BAN could significantly enhance the killing effect of BAN on 
      MCF-7 cells, and the folic acid-mediated targeting could lead to better uptake of 
      nanoparticles by tumor cells and thus better killing of cancer cells. In vivo 
      studies also showed that PEG-FA@ZIF-8@BAN significantly increased the inhibition 
      of the proliferation of solid breast cancer tumors (p < 0.01 or p < 0.001). 
      CONCLUSION: The PEG-FA@ZIF-8@BAN nano-drug delivery system significantly enhanced 
      the anti-breast cancer effect of baicalin both in vivo and in vitro, providing a 
      more promising drug delivery system for the clinical applications and tumor 
      management.
CI  - (c) 2021 Mi et al.
FAU - Mi, Xiao
AU  - Mi X
AD  - Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, 
      Peking Union Medical College, Beijing, 100094, People's Republic of China.
FAU - Hu, Meigeng
AU  - Hu M
AD  - Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, 
      Peking Union Medical College, Beijing, 100094, People's Republic of China.
FAU - Dong, Mingran
AU  - Dong M
AD  - Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, 
      Peking Union Medical College, Beijing, 100094, People's Republic of China.
FAU - Yang, Zhihong
AU  - Yang Z
AD  - Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, 
      Peking Union Medical College, Beijing, 100094, People's Republic of China.
FAU - Zhan, Xia
AU  - Zhan X
AD  - Key Laboratory of Cleaner Production and Integrated Resource Utilization of China 
      National Light Industry, Beijing Technology and Business University, Beijing, 
      100048, People's Republic of China.
FAU - Chang, Xinyue
AU  - Chang X
AD  - Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, 
      Peking Union Medical College, Beijing, 100094, People's Republic of China.
FAU - Lu, Juan
AU  - Lu J
AD  - Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, 
      Peking Union Medical College, Beijing, 100094, People's Republic of China.
FAU - Chen, Xi
AU  - Chen X
AD  - Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, 
      Peking Union Medical College, Beijing, 100094, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20211224
PL  - New Zealand
TA  - Int J Nanomedicine
JT  - International journal of nanomedicine
JID - 101263847
RN  - 0 (Drug Carriers)
RN  - 0 (Flavonoids)
RN  - 0 (Nanoparticle Drug Delivery System)
RN  - 1318-02-1 (Zeolites)
RN  - 347Q89U4M5 (baicalin)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Animals
MH  - *Breast Neoplasms/drug therapy
MH  - Cell Line, Tumor
MH  - Drug Carriers/therapeutic use
MH  - Drug Delivery Systems
MH  - Female
MH  - Flavonoids
MH  - Folic Acid/therapeutic use
MH  - Humans
MH  - Mice
MH  - Nanoparticle Drug Delivery System
MH  - *Nanoparticles
MH  - *Zeolites
PMC - PMC8714011
OTO - NOTNLM
OT  - baicalin
OT  - breast cancer therapy
OT  - folic acid response
OT  - metal-organic framework
COIS- The authors report no conflicts of interest in this work.
EDAT- 2022/01/08 06:00
MHDA- 2022/01/11 06:00
PMCR- 2021/12/24
CRDT- 2022/01/07 06:19
PHST- 2021/09/27 00:00 [received]
PHST- 2021/12/14 00:00 [accepted]
PHST- 2022/01/07 06:19 [entrez]
PHST- 2022/01/08 06:00 [pubmed]
PHST- 2022/01/11 06:00 [medline]
PHST- 2021/12/24 00:00 [pmc-release]
AID - 340764 [pii]
AID - 10.2147/IJN.S340764 [doi]
PST - epublish
SO  - Int J Nanomedicine. 2021 Dec 24;16:8337-8352. doi: 10.2147/IJN.S340764. 
      eCollection 2021.