PMID- 34992398
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220108
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 14
DP  - 2021
TI  - A Potential Participant in Type 2 Diabetes Bone Fragility: TIMP-1 at Sites of 
      Osteocyte Lacunar-Canalicular System.
PG  - 4903-4909
LID - 10.2147/DMSO.S345081 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is associated with an increased risk of bone 
      fracture, but the bone mineral density (BMD) is typically normal or higher in 
      such patients. Because the fracture risk is independent of reduced BMD, bone 
      fragility in T2DM may be partially due to poor bone quality. The mechanisms 
      triggering bone quality abnormalities in T2DM are complex, and include the 
      accumulation of advanced glycation end-products, the increased inflammation, and 
      low bone turnover. Matrix metalloproteinases (MMPs) in bone can hydrolyze the 
      bone matrix. Tissue inhibitors of MMPs (TIMPs) can inhibit the activity of MMPs. 
      Both MMPs and TIMPs participate in mediating bone quality. Among all types of 
      TIMPs, TIMP-1 is mostly reportedly increased in the serum of T2DM patients. 
      Because osteocytes can express TIMP-1, and osteocyte pericellular matrix 
      influences bone quality partially regulated by perilacunar/canalicular 
      remodeling, we hypothesized that TIMP-1 at sites of osteocyte lacunar-canalicular 
      system is involved in T2DM bone fragility.
CI  - (c) 2021 Pei et al.
FAU - Pei, Qilin
AU  - Pei Q
AD  - Institute of Life Sciences, Chongqing Medical University, Chongqing, 400016, 
      People's Republic of China.
FAU - Li, Jun
AU  - Li J
AD  - Department of Orthopedic Surgery, Chengdu Fifth People's Hospital, Chengdu, 
      Sichuan Province, 610072, People's Republic of China.
FAU - Zhou, Pengfei
AU  - Zhou P
AD  - Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Stomatological 
      Hospital of Chongqing Medical University, Chongqing, 401147, People's Republic of 
      China.
FAU - Zhang, Jun
AU  - Zhang J
AUID- ORCID: 0000-0002-5843-8705
AD  - Institute of Life Sciences, Chongqing Medical University, Chongqing, 400016, 
      People's Republic of China.
FAU - Huang, Peng
AU  - Huang P
AD  - Institute of Life Sciences, Chongqing Medical University, Chongqing, 400016, 
      People's Republic of China.
FAU - Fan, Jingchuan
AU  - Fan J
AD  - Institute of Life Sciences, Chongqing Medical University, Chongqing, 400016, 
      People's Republic of China.
FAU - Zou, Zhen
AU  - Zou Z
AUID- ORCID: 0000-0002-1651-591X
AD  - Institute of Life Sciences, Chongqing Medical University, Chongqing, 400016, 
      People's Republic of China.
FAU - Li, Xi
AU  - Li X
AD  - Institute of Life Sciences, Chongqing Medical University, Chongqing, 400016, 
      People's Republic of China.
FAU - Wang, Bin
AU  - Wang B
AUID- ORCID: 0000-0003-0225-9393
AD  - Institute of Life Sciences, Chongqing Medical University, Chongqing, 400016, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20211223
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC8711839
OTO - NOTNLM
OT  - TIMP-1
OT  - bone fragility
OT  - lacunar-canalicular system
OT  - osteocyte
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflicts of interest.
EDAT- 2022/01/08 06:00
MHDA- 2022/01/08 06:01
PMCR- 2021/12/23
CRDT- 2022/01/07 06:20
PHST- 2021/10/19 00:00 [received]
PHST- 2021/12/12 00:00 [accepted]
PHST- 2022/01/07 06:20 [entrez]
PHST- 2022/01/08 06:00 [pubmed]
PHST- 2022/01/08 06:01 [medline]
PHST- 2021/12/23 00:00 [pmc-release]
AID - 345081 [pii]
AID - 10.2147/DMSO.S345081 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2021 Dec 23;14:4903-4909. doi: 10.2147/DMSO.S345081. 
      eCollection 2021.