PMID- 34993031
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220108
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 11
DP  - 2021 Nov
TI  - Severe Symptomatic Hypercalcemia in a Patient With Familial Hypocalciuric 
      Hypercalcemia.
PG  - e20057
LID - 10.7759/cureus.20057 [doi]
LID - e20057
AB  - One of the less common causes of hypercalcemia is familial hypocalciuric 
      hypercalcemia (FHH). It is an autosomal-dominant genetic condition, which 
      presents asymptomatically in most patients while some may have mild symptoms. The 
      serum calcium levels are mildly elevated with mild elevation in parathyroid 
      hormone, which rarely requires management with pharmacologic agents. We present 
      an unusual case report of a 76-year-old woman, confirmed to have FHH type 1 
      mutation, presented with symptomatic hypercalcemia probably set off by metabolic 
      stresses of her age and needing intensive treatment with intravenous 
      bisphosphonates, calcitonin and cinacalcet.
CI  - Copyright (c) 2021, Kurian et al.
FAU - Kurian, Roshini
AU  - Kurian R
AD  - Chemical Pathology, University Hospitals of Leicester, National Health Service 
      Trust, Leicester, GBR.
FAU - Madegowda Chandrashekar, Gagan
AU  - Madegowda Chandrashekar G
AD  - Gastroenterology, University Hospital of North Durham, Durham, GBR.
FAU - Antony, Mc Anto
AU  - Antony MA
AD  - Endocrinology, Diabetes and Metabolism, Medical University of South Carolina, 
      Anderson, USA.
FAU - Chandra, Lakshya
AU  - Chandra L
AD  - Internal Medicine, Bon Secour St. Francis Hospital, Greenville, USA.
FAU - Kant, Ravi
AU  - Kant R
AD  - Endocrinology, Diabetes and Metabolism, Medical University of South Carolina, 
      Anderson, USA.
LA  - eng
PT  - Case Reports
DEP - 20211130
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8720036
OTO - NOTNLM
OT  - casr mutation
OT  - cinacalcet
OT  - corrected serum calcium
OT  - familial hypocalciuric hypercalcemia
OT  - urine calcium
OT  - zolendronic acid
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/01/08 06:00
MHDA- 2022/01/08 06:01
PMCR- 2021/11/30
CRDT- 2022/01/07 06:27
PHST- 2021/11/30 00:00 [accepted]
PHST- 2022/01/07 06:27 [entrez]
PHST- 2022/01/08 06:00 [pubmed]
PHST- 2022/01/08 06:01 [medline]
PHST- 2021/11/30 00:00 [pmc-release]
AID - 10.7759/cureus.20057 [doi]
PST - epublish
SO  - Cureus. 2021 Nov 30;13(11):e20057. doi: 10.7759/cureus.20057. eCollection 2021 
      Nov.