PMID- 34993212
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220108
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 8
DP  - 2021
TI  - Comparison of Intraocular Cytokine Levels of Choroidal Neovascularization 
      Secondary to Different Retinopathies.
PG  - 783178
LID - 10.3389/fmed.2021.783178 [doi]
LID - 783178
AB  - Purpose: To investigate and compare the aqueous concentrations of vascular 
      endothelial growth factor (VEGF) and other inflammatory cytokines in various 
      choroidal neovascularization (CNV) diseases and types. Methods: This 
      observational study included 127 naive eyes with CNV and 43 control eyes with 
      cataracts. Aqueous humor (AH) samples were obtained prior to intravitreal 
      anti-VEGF injection or cataract surgery. Multiple inflammatory cytokines, 
      including VEGF, interleukin (IL) 6, IL-8, IL-10, interferon-inducible protein 10 
      (IP-10), and monocyte chemotactic protein 1 (MCP-1) levels, were measured using a 
      multiplex bead assay. The angiogenesis index was defined as the ratio of IP-10 to 
      MCP-1. In addition, the relationship among AH cytokine levels, central macular 
      thickness (CMT), and CNV size on optical coherence tomography angiography (OCTA) 
      was evaluated. Results: Except in the myopic CNV group (P = 0.452), the AH 
      concentration of VEGF was significantly higher in all other CNV groups than in 
      the control group (P < 0.05 for all comparisons). IL-8, IL-10, IP-10, and MCP-1 
      levels (P < 0.05 for all groups) were significantly higher in all CNV diseases 
      except those with neovascular central serous chorioretinopathy. The angiogenesis 
      index was significantly higher in all CNV diseases (P < 0.05 for all 
      comparisons). The VEGF level may be associated with the size of the CNV on OCTA 
      (p = 0.043). Conclusions: The level of intraocular inflammatory cytokines varied 
      among different CNV diseases and CNV types. Therefore, the angiogenesis index may 
      be a more sensitive indicator of angiogenesis.
CI  - Copyright (c) 2021 Liu, Zhang, Deng, Chen, Shen, Hu and Mao.
FAU - Liu, Chenyi
AU  - Liu C
AD  - School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, 
      China.
FAU - Zhang, Shian
AU  - Zhang S
AD  - School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, 
      China.
AD  - Eye Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Deng, Xinyi
AU  - Deng X
AD  - School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, 
      China.
AD  - Eye Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Chen, Yijing
AU  - Chen Y
AD  - School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, 
      China.
AD  - Eye Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Shen, Lijun
AU  - Shen L
AD  - School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, 
      China.
AD  - Eye Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Hu, Liang
AU  - Hu L
AD  - School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, 
      China.
AD  - Eye Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Mao, Jianbo
AU  - Mao J
AD  - School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, 
      China.
AD  - Eye Hospital of Wenzhou Medical University, Wenzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20211221
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC8725795
OTO - NOTNLM
OT  - age-related macular degeneration (AMD)
OT  - central serous chorioretinopathy (CSC)
OT  - choroidal neovascularization
OT  - cytokine
OT  - high myopic
OT  - polypoidal choroidal vasculopathy (PCV)
OT  - vascular endothelial growth factor
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/01/08 06:00
MHDA- 2022/01/08 06:01
PMCR- 2021/12/21
CRDT- 2022/01/07 06:29
PHST- 2021/09/25 00:00 [received]
PHST- 2021/12/01 00:00 [accepted]
PHST- 2022/01/07 06:29 [entrez]
PHST- 2022/01/08 06:00 [pubmed]
PHST- 2022/01/08 06:01 [medline]
PHST- 2021/12/21 00:00 [pmc-release]
AID - 10.3389/fmed.2021.783178 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2021 Dec 21;8:783178. doi: 10.3389/fmed.2021.783178. 
      eCollection 2021.