PMID- 34993909
OWN - NLM
STAT- MEDLINE
DCOM- 20220816
LR  - 20220816
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 200
IP  - 9
DP  - 2022 Sep
TI  - The Relationship Between Preeclampsia and Arsenic Concentration in the Peripheral 
      Blood.
PG  - 3965-3974
LID - 10.1007/s12011-021-02988-5 [doi]
AB  - Preeclampsia (PE) is a pregnancy-specific disorder, which is one of the leading 
      causes of maternal, fetal, and neonatal death, particularly in developing 
      countries. Arsenic (As), which is commonly found in soil and groundwater, has 
      been associated with various complications of pregnancy, such as spontaneous 
      abortion, hypertension, and stillbirth. Hence, the study was used to explore the 
      relationship between PE and blood concentration of As in this study. Blood 
      concentration of As during pregnancy was measured by inductively coupled plasma 
      mass spectrometry (ICP-MS). The results shown that the mean blood concentration 
      of As was gradually increased from the control group to the severe PE group 
      (P < 0.0001). Elevated blood concentration of As was associated with the 
      prevalence of PE (OR = 12.81, 95% CI: 2.43-67.39 and 27.55, 1.75-433.43 for 
      middle and high vs. low). Furthermore, elevated blood concentration of As was 
      associated with the severity of PE. Additionally, we observed that blood 
      concentration of As was associated with the hypoproteinemia (P = 0.001, 
      r(s) = 0.37). Blood concentration of As was negatively corelated with the mean 
      corpuscular volume (MCV) (P = 0.040, r(s) =  - 0.23) and positively corelated 
      with the mean corpuscular hemoglobin concentration (MCHC) (P = 0.044, 
      r(s) = 0.23). Overall, our results indicated that the blood concentration of As 
      can significantly predict the occurrence of PE. Additionally, we provided 
      evidence that blood concentration of As may affect the occurrence of 
      hypoproteinemia. These findings may provide some ideas for the prevention of PE 
      and pregnancy complications.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Liu, Haixia
AU  - Liu H
AD  - Institute of Maternal, Child and Adolescent Health, School of Public Health, 
      Lanzhou University, Lanzhou, China.
FAU - Pu, Yudong
AU  - Pu Y
AD  - Songshan Lake Central Hospital of Dongguan City, Dongguan, China.
FAU - Ai, Shiwei
AU  - Ai S
AD  - Institute of Maternal, Child and Adolescent Health, School of Public Health, 
      Lanzhou University, Lanzhou, China.
FAU - Wang, Xiaoxue
AU  - Wang X
AD  - Institute of Maternal, Child and Adolescent Health, School of Public Health, 
      Lanzhou University, Lanzhou, China.
FAU - He, Shuzhen
AU  - He S
AD  - Songshan Lake Central Hospital of Dongguan City, Dongguan, China.
FAU - Wang, Ke
AU  - Wang K
AD  - Institute of Maternal, Child and Adolescent Health, School of Public Health, 
      Lanzhou University, Lanzhou, China.
FAU - Dang, Yuhui
AU  - Dang Y
AUID- ORCID: 0000-0002-5728-7247
AD  - Institute of Maternal, Child and Adolescent Health, School of Public Health, 
      Lanzhou University, Lanzhou, China. dangyh@lzu.edu.cn.
LA  - eng
GR  - No. lzujbky-2019-6)/the fundamental research funds for the central universities/
GR  - No. 2015108101033/the social science and technology development (key) fund of 
      dongguan city of china/
PT  - Journal Article
PT  - Review
DEP - 20220107
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - *Abortion, Spontaneous
MH  - *Arsenic
MH  - Female
MH  - Fetal Blood
MH  - Humans
MH  - *Hypoproteinemia
MH  - Infant, Newborn
MH  - *Pre-Eclampsia
MH  - Pregnancy
OTO - NOTNLM
OT  - Arsenic
OT  - Blood
OT  - Hypoproteinemia
OT  - Logistic regression
OT  - Preeclampsia
EDAT- 2022/01/08 06:00
MHDA- 2022/08/17 06:00
CRDT- 2022/01/07 06:45
PHST- 2021/06/25 00:00 [received]
PHST- 2021/10/20 00:00 [accepted]
PHST- 2022/01/08 06:00 [pubmed]
PHST- 2022/08/17 06:00 [medline]
PHST- 2022/01/07 06:45 [entrez]
AID - 10.1007/s12011-021-02988-5 [pii]
AID - 10.1007/s12011-021-02988-5 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2022 Sep;200(9):3965-3974. doi: 10.1007/s12011-021-02988-5. 
      Epub 2022 Jan 7.