PMID- 34994485
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220406
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 36
IP  - 2
DP  - 2022 Mar
TI  - Changes in renin-angiotensin-aldosterone system during cardiac remodeling after 
      mitral valvuloplasty in dogs.
PG  - 397-405
LID - 10.1111/jvim.16346 [doi]
AB  - BACKGROUND: Information regarding changes in renin-angiotensin-aldosterone system 
      (RAAS) during cardiac remodeling after mitral valvuloplasty (MVP) in dogs remains 
      lacking. HYPOTHESIS/OBJECTIVES: To assess the longitudinal effects of MVP on 
      circulating RAAS activity. ANIMALS: Eight client-owned dogs receiving MVP for 
      myxomatous mitral valve disease (MMVD). METHODS: This is a cohort study. Plasma 
      renin activity (PRA), angiotensin II (AT2), aldosterone (PAC), blood urea 
      nitrogen (BUN), and creatinine concentrations, were measured in these dogs before 
      (baseline) and at 3 consecutive monthly follow-ups (Post-1M, Post-2M, Post-3M). 
      Echocardiography was concomitantly used to assess the process of cardiac recovery 
      after MVP. RESULTS: The echocardiography revealed a significant decrease in 
      LVIDDN, LA/Ao, FS, E velocity, E/A, E' sep, S' lat, E' lat, and A' lat after MVP 
      compared with baseline (P < .05). There was a significant reduction in the PRA 
      (2.45, 3.05, 2.74 vs 8.8 ng/mL/h; P = .002), AT2 (466, 315, 235 vs 1200 pg/mL; 
      P = .009), and PAC (39.88, 47, 54.62 vs 179.5 pg/mL; P = .01), respectively at 
      Post-1M, Post-2M, Post-3M compared to the baseline. Additionally, BUN and 
      creatinine concentrations decreased from Post-1M. The RAAS variables showed 
      significant, weak to moderate, relationship with selected echocardiographic 
      variables. CONCLUSIONS AND CLINICAL IMPORTANCE: Mitral valvuloplasty contributes 
      to decreased RAAS activity in MMVD dogs, which paralleled the process of cardiac 
      reverse remodeling up to Post-3M. This information facilitates formulating 
      strategies to optimize clinical outcomes for dogs after MVP.
CI  - (c) 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley 
      Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
FAU - Cheng, Chieh-Jen
AU  - Cheng CJ
AUID- ORCID: 0000-0003-3376-5440
AD  - Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, 
      College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
AD  - Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology, 
      Fuchu, Tokyo, Japan.
AD  - VCA Japan Shiraishi Animal Hospital, Sayama, Saitama, Japan.
FAU - Mandour, Ahmed S
AU  - Mandour AS
AUID- ORCID: 0000-0001-6256-4539
AD  - Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology, 
      Fuchu, Tokyo, Japan.
AD  - Department of Animal Medicine (Internal Medicine), Faculty of Veterinary 
      Medicine, Suez Canal University, Ismailia, Egypt.
FAU - Yoshida, Tomohiko
AU  - Yoshida T
AD  - Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology, 
      Fuchu, Tokyo, Japan.
AD  - VCA Japan Shiraishi Animal Hospital, Sayama, Saitama, Japan.
FAU - Watari, Toshihiro
AU  - Watari T
AUID- ORCID: 0000-0002-7076-3682
AD  - Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, 
      College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
FAU - Tanaka, Ryou
AU  - Tanaka R
AUID- ORCID: 0000-0001-9948-6490
AD  - Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology, 
      Fuchu, Tokyo, Japan.
FAU - Matsuura, Katsuhiro
AU  - Matsuura K
AUID- ORCID: 0000-0002-6047-2865
AD  - Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology, 
      Fuchu, Tokyo, Japan.
AD  - VCA Japan Shiraishi Animal Hospital, Sayama, Saitama, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220107
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - 4964P6T9RB (Aldosterone)
SB  - IM
MH  - Aldosterone
MH  - Animals
MH  - Cohort Studies
MH  - *Dog Diseases/diagnostic imaging/therapy
MH  - Dogs
MH  - Humans
MH  - Mitral Valve
MH  - *Renin-Angiotensin System
MH  - Ventricular Remodeling
PMC - PMC8965262
OTO - NOTNLM
OT  - angiotensin II
OT  - biomarker
OT  - cardiac recovery
OT  - cardiac reverse remodeling
OT  - mitral valve repair
OT  - plasma renin activity
COIS- Authors declare no conflict of interest.
EDAT- 2022/01/08 06:00
MHDA- 2022/04/01 06:00
PMCR- 2022/03/01
CRDT- 2022/01/07 08:52
PHST- 2021/12/07 00:00 [revised]
PHST- 2021/05/20 00:00 [received]
PHST- 2021/12/13 00:00 [accepted]
PHST- 2022/01/08 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2022/01/07 08:52 [entrez]
PHST- 2022/03/01 00:00 [pmc-release]
AID - JVIM16346 [pii]
AID - 10.1111/jvim.16346 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2022 Mar;36(2):397-405. doi: 10.1111/jvim.16346. Epub 2022 Jan 
      7.