PMID- 34995522
OWN - NLM
STAT- MEDLINE
DCOM- 20220530
LR  - 20220630
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 238
DP  - 2022 Jun
TI  - Intraocular Inflammation in Eyes Operated for Late In-the-bag intraOcular lens 
      dislocatioN (LION): A Randomized Clinical Trial.
PG  - 66-74
LID - S0002-9394(21)00662-0 [pii]
LID - 10.1016/j.ajo.2021.12.019 [doi]
AB  - PURPOSE: To compare the intraocular inflammation after 2 surgical approaches for 
      late in-the-bag intraocular lens (IOL) dislocation. DESIGN: Prospective, 
      randomized, parallel-group clinical trial. METHODS: We randomly assigned 100 
      patients (100 eyes) referred to Oslo University Hospital (tertiary referral 
      center) with late in-the-bag IOL dislocation into IOL repositioning by scleral 
      suturing (n=49) or IOL exchange with retropupillary fixation of an iris-claw lens 
      (n=51). Patients were examined before surgery and 2 weeks, 6 weeks, and 6 months 
      after surgery. The main outcome measure was anterior chamber laser flare, 
      measured with a laser flare meter as photon counts per millisecond (pc/ms). 
      RESULTS: Two weeks following surgery, median flare values were 28.9 pc/ms (range, 
      7.9-140) in the repositioning group and 31.6 pc/ms (range, 9.8-92.3) in the 
      exchange group (P = .83). Flare levels were still elevated after 6 weeks with no 
      difference between the groups (P = .93), whereas it decreased to baseline levels 
      after 6 months. Six weeks following surgery, the central retinal thickness was 
      similar (P = .97); cystoid macular edema (CME) was found in 4 and 5 patients, 
      respectively (P = .85); and the mean best corrected visual acuity was 0.17 (95% 
      CI 0.09, 0.25) and 0.21 (95% CI 0.09, 0.32) logarithm of the minimum angle of 
      resolution, respectively (P = .61). CONCLUSIONS: This study revealed similar 
      levels of intraocular inflammation following IOL repositioning and IOL exchange. 
      There was no significant difference regarding risk of CME and visual outcome. The 
      prolonged elevation in postoperative flare indicates a possible requirement for 
      an extended anti-inflammatory treatment period after these operations.
CI  - Copyright (c) 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Medin, Helle
AU  - Medin H
AD  - From the Department of Ophthalmology, Oslo University Hospital (H.M., M.D., 
      I.S.H.K., M.K., L.D., O.K.); Institute of Clinical Medicine, University of Oslo 
      (H.M., M.K., L.D., O.K.), Oslo, Norway. Electronic address: hellemedin@gmail.com.
FAU - Dalby, Marius
AU  - Dalby M
AD  - From the Department of Ophthalmology, Oslo University Hospital (H.M., M.D., 
      I.S.H.K., M.K., L.D., O.K.).
FAU - Kure, Ingeborg Slordahl Hjort
AU  - Kure ISH
AD  - From the Department of Ophthalmology, Oslo University Hospital (H.M., M.D., 
      I.S.H.K., M.K., L.D., O.K.).
FAU - Karabeg, Mia
AU  - Karabeg M
AD  - From the Department of Ophthalmology, Oslo University Hospital (H.M., M.D., 
      I.S.H.K., M.K., L.D., O.K.); Institute of Clinical Medicine, University of Oslo 
      (H.M., M.K., L.D., O.K.), Oslo, Norway.
FAU - Drolsum, Liv
AU  - Drolsum L
AD  - From the Department of Ophthalmology, Oslo University Hospital (H.M., M.D., 
      I.S.H.K., M.K., L.D., O.K.); Institute of Clinical Medicine, University of Oslo 
      (H.M., M.K., L.D., O.K.), Oslo, Norway.
FAU - Kristianslund, Olav
AU  - Kristianslund O
AD  - From the Department of Ophthalmology, Oslo University Hospital (H.M., M.D., 
      I.S.H.K., M.K., L.D., O.K.); Institute of Clinical Medicine, University of Oslo 
      (H.M., M.K., L.D., O.K.), Oslo, Norway.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20220105
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Humans
MH  - Inflammation/etiology
MH  - *Lens Subluxation/surgery
MH  - *Lenses, Intraocular
MH  - Postoperative Complications
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Visual Acuity
EDAT- 2022/01/08 06:00
MHDA- 2022/05/31 06:00
CRDT- 2022/01/07 20:11
PHST- 2021/11/01 00:00 [received]
PHST- 2021/12/21 00:00 [revised]
PHST- 2021/12/29 00:00 [accepted]
PHST- 2022/01/08 06:00 [pubmed]
PHST- 2022/05/31 06:00 [medline]
PHST- 2022/01/07 20:11 [entrez]
AID - S0002-9394(21)00662-0 [pii]
AID - 10.1016/j.ajo.2021.12.019 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2022 Jun;238:66-74. doi: 10.1016/j.ajo.2021.12.019. Epub 2022 
      Jan 5.